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Y-chromosome DNA on this is passed down the paternal line with usually no change. Every few hundred years however there may be a change in one of the repeated.

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Presentation on theme: "Y-chromosome DNA on this is passed down the paternal line with usually no change. Every few hundred years however there may be a change in one of the repeated."— Presentation transcript:

1 Y-chromosome DNA on this is passed down the paternal line with usually no change. Every few hundred years however there may be a change in one of the repeated sequences of DNA called “”Short tandem repeats” or “STRs”. We can analyse these STRs using techniques known as “PCR” and electrophoresis to produce a DNA “fingerprint”.

2 STRs Z Z Z Z Z Z Z Z Z The rows Z7, Z24 etc correspond to particular individuals. The columns 391, 390 etc correspond to the different number of STRs in 6 markers or parts of the Y- chromosome. The sequence of numbers etc. is known as a persons “haplotype”. We can enter this data into a database known as YHRD to look for matches with over other people tested in Europe.

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4 HIT MISS 17 The numbers refer to the place. E.g. 17 = Croatia Here are a few examples….

5 Kevin Sampson267 matches/13003

6 Kevin Sampson267 matches/13003 So Kevin’s paternal ancestor “may” have come from this area

7 Chris Westhead, John Aindow, Roger Martlew, Alan Scarisbrick, Gordon Ashcroft, Tom Howard, John Rosbotham, Norman Penketh, Edward Webster, Ole Christiansen

8 Michael Fletcher166 matches/13003

9 Keith Rimmer89 matches/13003

10 Stanley Lunt339 matches/13003

11 John Risley 8 matches/13003

12 Michael Welch441 matches/13443

13 Tony Tottey166 matches/13003

14 Brian Totty166 matches/13003

15 STRs Z Z Z Z Z Z Z Z Z YHRD now allows “nearest neighbour” analysis”: during the course of 1000 years it is possible that there has been a single mutation of one of the Y-chromosome STRs along a man’s paternal ancestral line. e.g. for the man “Z7” the marker 391 could have originally been 9 or 11 repeats. Some mutations are rare and yield no matches.

16 Richard Harding’s Y-chromosome group One step mutation of one of his STR’s: Top matches for each mutation: West Norway (2ce) Oslo Puglia (followed by Central Norway) Vasterbotten, Sweden Uppsala Denmark No mutation, top matches: Ostgotland-Jonköping, Sweden and Gröningen, Friesland: ~8% of men have a match. Where the top matches for Richard’s Y-chromosome are to be found


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