Presentation on theme: "WHO MEC: Special situations"— Presentation transcript:
1 WHO MEC: Special situations This document is one important step in a process for improving access to quality of care in family planning by reviewing the medical eligibility criteria for selecting methods of contraception. It updates the third edition of Medical eligibility criteria for contraceptive use, published in 2004, and summarizes the main recommendations of an expert Working Group meeting held at the World Health Organization, Geneva,1–4 April 2008.The document provides recommendations for appropriate medical eligibility criteria based on the latest clinical and epidemiological data and is intended to be used by policy-makers, family planning programme managers and the scientific community. It aims to provide guidance to national family planning/reproductive health programmes in the preparation of guidelines for service delivery ofcontraceptives.MAR-2011-AP-(IN)-3627-SS 30-Aug-2012
2 Efficacy of methodsTrussel's review contains the results of individual published surveys and studies. Failure rates (percentage of women with unintended pregnancy during the first year of use) are calculated for both perfect and typical use.The failure rate of some methods is the same with perfect and with typical use (eg, Implanon® birth control implant), whereas the difference in failure rate between perfect and typical use of other methods is significant (eg, withdrawal). Hormonal methods (pill, ring, patch, Depo-Provera®) are very effective when used perfectly (failure rate less than 1%), but with typical use the failure rate is upto 8%.Details of the table:Percentage of women experiencing an unintended pregnancy during the first year of typical useand the first year of perfect use of contraception and the percentage continuing use at the end of the firstyear. United States of America.1. Among typical couples who initiate use of a method (not necessarily for the first time), the percentage who experience an accidental pregnancy during the first year if they do not stop use for any other reason. Estimates of the probability of pregnancy during the first year of typical use for spermicides, withdrawal, fertility awareness-based methods, the diaphragm, the male condom, the pill, and Depo-Provera are taken from the 1995 National Survey of Family Growth corrected for underreporting of abortion; .2. Among couples who initiate use of a method (not necessarily for the first time) and who use it perfectly (both consistently and correctly), the percentage who experience an accidental pregnancy during the first year if they do not stop use for any other reason.3. Among couples attempting to avoid pregnancy, the percentage who continue to use a method for 1 year.4. The percentages becoming pregnant in columns (2) and (3) are based on data from populations where contraception is not used and from women who cease using contraception in order to become pregnant. Among such populations, about 89% become pregnant within 1 year. This estimate was lowered slightly (to 85%) to represent the percentage who would become pregnant within 1 year among women now relying on reversible methods of contraception if they abandoned contraception altogether.5. Foams, creams, gels, vaginal suppositories, and vaginal film.6. The Ovulation and TwoDay methods are based on evaluation of cervical mucus. The Standard Days method avoids intercourse on cycle days 8 through 19.7. With spermicidal cream or jelly.8. Without spermicides.9. Source: Trussell J. Contraceptive efficacy. In Hatcher RA, Trussell J, Stewart F, Nelson A, Cates W, Guest F, Kowal D.Contraceptive Technology: Eighteenth Revised Edition. New York, NY: Ardent Media, 200410. The treatment schedule is one dose within 120 hours after unprotected intercourse, and a second dose 12 hours after the first dose. Both doses of Plan B can be taken at the same time. Plan B (1 dose is 1 white pill) is the only dedicated product specifically marketed for emergency contraception. The Food and Drug Administration has in addition declared the following 22 brands of oral contraceptives to be safe and effective for emergency contraception: Ogestrel or Ovral (1 dose is 2 white pills), Levlen or Nordette (1 dose is 4 light-orange pills), Cryselle, Levora, Low-Ogestrel, Lo/Ovral, or Quasence (1 dose is 4 white pills), Tri-Levlen or Triphasil (1 dose is 4 yellow pills), Jolessa, Portia, Seasonale, or Trivora (1 dose is 4 pink pills), Seasonique (1 dose is 4 light-blue-green pills), Empresse (one dose is 4 orangepills), Alesse, Lessina, or Levlite, (1 dose is 5 pink pills), Aviane (one dose is 5 orange pills), and Lutera (one dose is 5 white pills).11. However, to maintain effective protection against pregnancy, another method of contraception must be used as soon as menstruation resumes, the frequency or duration of breastfeeds is reduced, bottle feeds are introduced, or the baby reaches 6 months of age.Percentage of women experiencing an unintended pregnancy during the first year of typical use and the first year of perfect use of contraception and the percentage continuing use at the end of the first year. United States of America.Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009
3 Contraceptive revolution – reversible methods These are the pictorial examples of various reversible contraceptives methods like pills, injection, Implant, condoms, IUDs, vaginal ring etc.
4 WHO medical eligibility criteria for contraceptive use: classification Condition:CategoryFor which there is no restriction on use of the method1Where the advantages generally outweigh the theoretical or proven risks2Where the theoretical or proven risks usually outweigh the advantages of using the method3Represents an unacceptable health risk of the contraceptive method if used4Using the categories in practiceCategories 1 and 4 are self-explanatory. Classification of a method/condition as category 2 indicates the method can generally be used, but careful follow-up may be required. However, provision of amethod to a woman with a condition classified as category 3 requires careful clinical judgement and access to clinical services; for such a woman, the severity of the condition and the availability, practicality, and acceptability of alternative methods should be taken into account. For a method/condition classified as category 3, use of that method is not usually recommended unless other more appropriate methods are not available or acceptable. Careful follow-up will be required.Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009
5 WHO medical eligibility criteria for contraceptive use: classification CategoryWith clinical judgementWith limited clinical judgement1use method in any circumstancesYes(use the method)2generally use the method3use of method not usuallyrecommended unless other moreappropriate methods are notavailable or not acceptableNo(do not use the method)4method not to be usedWhere resources for clinical judgment are limited, such as in community-based services, the four category classification framework can be simplifiedinto two categories. With this simplification, a classification of Category 3 indicates that a woman is not medically eligible to use the method.Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009
6 Contraceptive Methods Available in India Contraceptive Methods Available in India. Abbreviations mentioned in WHO MECLow-dose combined oral contraceptives: COCsCombined contraceptive Vaginal Ring: RProgestogen-only Pills: POPsDepot medroxyprogesterone acetate : DMPANorethisterone enantate : NET-NEIntrauterine devices IUDsLevonorgestrel-releasing IUD (20 g/24hours): LNG-IUDCopper-bearing IUD: Cu-IUDsImplant IMPMedical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009
7 Case 1 A 18 year old unmarried woman, seeking contraception advice She also c/o; constant pelvic pain worsening during mensesMedical History: NoneFamily History: No reports of bleeding disorderObstetrical History: G0P0A0Investigations: USG-NAD
8 WHO Guidelines Condition Category COC Dysmenorrhea 1 Evidence: There was no increased risk of side-effects with COC use among women with dysmenorrhoea compared with women notusing COCs. Some COC users had a reduction in pain and bleeding1Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009
9 Case-2 A 24 year old married woman, seeking contraception advice She also C/O: constant pelvic pain worsening during mensesMedical History: NoneFamily History: No reports of bleeding disorderObstetrical History: G0P0A0Investigations: USG- free fluid in the cul-de-sac
10 WHO Guidelines Condition Category COC Endometriosis 1 Evidence: A Cochrane Collaboration Review identified one randomized controlled trial evaluating the effectiveness of COC use compared with a GnRH analogue in treating the symptoms of endometriosis. Women with endometriosis did not report worsening of the condition or any adverse events related to COC use1.In patients of endometriosis seeking contraception, as per WHO MEC criteria, there is no restriction on use of COC.Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009Vercellini P, Trespidi L, Colombo A, Vendola N, Marchini M, Crosignani PG. A gonadotrophin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Fertility and Sterility 1993;60(1):75–9.
11 Case 3 A 35 year old female patient seeking advice on contraception C/O: heavy mensesFamily history: Mother underwent surgery for hysterectomy at the age of 45 due to uterine fibroidsObs/Gyn History: G1P1A0Investigations: USG- 4 heterogeneous structures, in the muscular layer without distortion of uterine cavity suggestive of leiomayomata.
12 (With or without distortion of uterine cavity) WHO GuidelinesConditionCategoryCOCUterine Fibroids(With or without distortion of uterine cavity)1Comments: COCs do not appear to cause growth of uterine fibroidsUterine fibroids: COCs do not appear to cause growth of uterine fibroids, and combined injectable contraceptivess, combined contraceptive patch, and combined contraceptive vaginal ring are not expected to either.Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009
13 Case 3A 30 year old female patient complaining about irregular bleeding pattern seeks advice on contraceptionFamily history: unknownPhysical examinations: mild acne lesions on face and hirsutism on face and limbsObs/Gyn History: G1P0A1
14 WHO Guidelines Condition Category COC Irregular pattern without heavy bleedingHeavy or prolonged bleeding(includes regular and irregular patterns)1Vaginal bleeding patterns: Irregular menstrual bleeding patterns are common among healthy women. There is no restriction for use of COC in women with irregular vaginal bleeding seeking contraception.Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009
15 MEC use in women with different patterns of vaginal bleeding (WHO MEC 2009) Vaginal Bleeding patternsHormonal contraceptivesProgesterone only PillsProgesterone onlyinjectionsIrregular bleeding without heavy bleeding12Heavy or prolonged bleeding (includesregular or irregular)Unexplained vaginal bleeding (suspiciousof serious pathology) before evaluation3Medical Eligibility criteria (MEC) 1: A condition for which there is no restriction for the use of the contraceptive method2: A condition for which the advantages of using the method generally outweigh the theoretical or proven risks3: A condition where the theoretical or proven risks usually outweigh the advantages of using the method4: A condition that represents an unacceptable health risk if the contraceptive method is used.
16 DSG+EE Vs LNG+EE: Which one has better affect on acne hirsutism and weight change Sanam and Ziba, Saudi Med J 32:23-26, 2011
17 Design and Method Amir hospital & Health Centers, Family Planning Women ranging from years with no contraindication to OCs and have not used hormonal contraception in past 6 monthsAmir hospital &Family PlanningClinicHealth Centers,Samnan, Irann=100Baseline analysis: weight, acne, number of leisions, hirsutism evaluation, SHBG levels and free testosteroneDSG+EE Grpn=50Randomization0 monthsLNG+EE Grpn=501months2 months3 months4 months6 months5 monthsOutcome analysis: weight, acne, number of leisions, hirsutism evaluation, SHBG levels and free testosterone
18 The effect of the pill on weight, hirsutism and acne 0.0121.0±2.02.8±4.2Terminal hirsutism severity0.000-1.7±2.90.3±1.8Hirsutism severity changes0.8362.7±4.42.5±4.3Base hirsutism severityHirsutism0.001-3.0±6.20.4±3.3Number of acne changes0.0111.8±3.64.7±6.7Terminal number of acne0.7584.8±8.24.3±7.0Base number of acneAcne0.0±2.53.3±3.6Weight Changes (Kg)0.90265.3±11.065.8±15.6Terminal Weight (Kg)0.57665.3±10.663.2±15.6Base Weight (Kg)WeightP-ValueDSG+EELNG+EEParametersSanam and Ziba, Saudi Med J 32:23-26, 2011
19 Case 4 A 28 year old female patient seeking advice on contraception C/O: constant lower abdominal pain and lower back painObs/Gyn History: G0P0A1 . (Surgical abortion of an unplanned pregnancy at a local clinic, two months ago.)Investigations: USG- Relevant findings in transvaginal sonogram shows normal ovary close to thickened fallopian tube in right adnexa
20 Pelvic Inflammatory Disease WHO GuidelinesConditionCategoryCOCPelvic Inflammatory Disease(PID-Current)1Comments: COCs may reduce the risk of PID.Pelvic inflammatory disease (PID): COCs may reduce the risk of PID among women with STIs, but do not protect against HIV or lower genital tract STIs.Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009
21 A summary of a few more situations where COC are favorable… ConditionCategoryAdditional Notes(Evidence/Comments)COCGestational Trophoblastic Disease(decreasing or undetectable levels of β-HCG/ persistently elevated β-HCG levels or malignant disease)1Evidence found COC use did not increase the risk of postmolar trophoblastic disease and some COC users experienced a more rapid regression in hCG levels, compared with non-users.Endometrial CancerCOC use reduces the risk of developing endometrial cancer. While awaiting treatment, women may use COCs. In general, treatment of this condition renders a woman sterile.Ovarian CancerCOC use reduces the risk of developing ovarian cancer. While awaiting treatment, women may use COCs. In general, treatment of this condition renders a woman sterile.Cervical EctropionCervical ectropion is not a risk factor for cervical cancer, and there is no need for restriction of combined hormonal contraceptive useGestational Trophoblastic Disease: Evidence: Following molar pregnancy evacuation, the balance of evidence found COC use did not increase the risk of postmolar trophoblastic disease and some COC users experienced a more rapid regression in hCG levels, compared with non-users. Limited evidence suggests that use of COCs during chemotherapeutic treatment does not significantly affect the regression or treatment of post-molar trophoblastic disease compared with women who used a non-hormonal contraceptive method or DMPA during chemotherapeutic treatment.Medical eligibility criteria for contraceptive use. (ed 4). A WHO Family planning cornerstone. 2009MAR-2011-AP-(IN)-3627-SS 30-Aug-2012