Presentation on theme: "Research Summary 08/2010 Dr. Andrej Mošat` Prof. A. Linninger, Laboratory for Product and Process Design, M/C 063 University of Illinois at Chicago 04."— Presentation transcript:
Research Summary 08/2010 Dr. Andrej Mošat` Prof. A. Linninger, Laboratory for Product and Process Design, M/C 063 University of Illinois at Chicago 04 August 2010
Autoregulation in Brain publication quality network image generator: Vector format
Approach to PBPK Modeling using Vasculature Network 1.2. Intrinsic Hepatic Clearance Tanaka: CL i = F(Hct, t, organ type) Our proposal: CL i = F(Hct) => const. 3. Kinetic organ models: F(C CyA (t, injection, CL liver, CL organs ), params(C plasma ) ) 4. Vasculature network combined with “tissue equations” 5. KIP for 1 parameter: CL i Result: C CyA,i =F(t)
Literature Review Cierra found: Gueorguieva, I.; Aarons, L.; Ogungbenro, K.; Jorga, K.; Rodgers, T. & Rowland, M. Optimal Design for Multivariate Response Pharmacokinetic Models Journal of Pharmacokinetics and Pharmacodynamics, 2006, 33, 97-124 “We assume that measurements made at distinct times are independent, but measurements made of each concentration are correlated with a response variance--covariance matrix. “
Outlook Test rSQP for KIP of a “Rat50” model Research Global optimization methods Outline of a paper REU preparation
Experiment: Rats’ Blood and Tissue concentrations of CyA Tissue concentration-to-time profiles of CyA in various organs of rats after 1.2- (circles), 6- (squares), and 30- (triangles) mg/kg doses. Each measurement in the unit of mg/ml or g represents an average value from three rats with S.D. (vertical bar). The solid line is log-linear interpolation between the measurements. Blood
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