2 Systemic lupus erythematosus autoimmune, organ non specific diseasehyperreaction of B-lymphocyts with production of antibodies agains organ non-specific antibodiesmultisystem diseaseunknown etiologyvariable course and prognosis
3 Clinical featuresInflammation in various organ systems including skin, mucose membrane, joints, kidney, brain, serous membrane, lung, heart, gastrontestinal tract.Involvement of organ- single or in combinationMortality: involvement of kidney and CNSGeneral clinical features- fatigue, fever, malaise, weight loss
4 Ethiology unknown, multifactorial exogenous: virus infection UV light stressdrugs: hydralazinendogenous: hormonalgenetic predispositionimmune reaction:hyperreactivity of B- cellspathologic T cell , failure of remove immune complexes
5 Clinical Features- general Subfebrility, fever- 80%Malaise, tirednessSkinMental disorders, psychiatric manifestationarthralgia, arthritisthrombosisChanges of blood count
6 The joint Arthritis, arthralgia – morning stiffness stuhnutosť Involvement: small joints of hand, wrist, knees,arthritis- is not erosiveMyositis- pain of involved muscles
30 Biopsies of the salivary gland or of the lipshow a focal infiltration of lymphocytes and plasma cells.Laboratory abnormalities: ESR, RF,ANA, anti-Ro (SSA), anti La (SSB) trombocytopaeniaTreatment: symptomaticantimalaric: hydroxychlorochinecorticosteroid drugs
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