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De androgeenreceptor is een transcriptiefactor
Androgens AR Δ Gene expression A A
Androgens affect: - Embryologic development - Bone and muscle - Male puberty - Behaviour - Reproduction - Prostate & PrCa - Osteoporosis and frailty Androgens Testosterone Dihydrotestosterone
Androgens AR Δ Gene expression A A
Gene regulation by testosterone Testosteron binds the androgen receptor The receptor binds DNA The receptor activates gene expression Therapies
DNA binding Ligand-bindingGene activation AF1 LBD AF2 AR: DBD The receptor binds testosterone
Testosterone binds the receptor
Effect of testosterone binding H1 H2 H3 H4 H5 6 H7 H8 H9 H10 H11 H12 S1 S2 no ligand H9 H1 H2 H3 H4 H5 H7 H8 H10 H11 H12 6 T + ligand LxxLL
Gene regulation by testosterone Testosteron activates the androgen receptor The receptor binds DNA The receptor activates gene expression Therapies
The DNA-binding domain of the AR AF1 LBD AF2 AR: DBD
DNA binding Ligand-binding How does testosterone affect gene expression? Gene activation AF1 LBD AF2 AR: DBD
Gene regulation by testosterone Testosteron binds the androgen receptor The receptor binds DNA The receptor activates gene expression
Histon code recognition erasing TIF1β Histon code and testosteron action CBP, P/CAF CARM1 Histon code writing p160 RNApol II recruitment expression TFIIF Tau-1 LBD AF2 AR: DBD Tau-5 Chromatin-remodeling complex
-CRC -TIF1b Testosteron effects on the histon code: a cartoon AR -p160 RNA polII -TFIIF
DNA binding Ligand-binding The DBD and LBD communicate Transactivation Tau-1 LBD AF2 AR: DBD Tau-5 Cycling partners Cycling histon code
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