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CHAPTER 32 DISORDERS OF ENDOCRINE FUNCTION Essentials of Pathophysiology.

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Presentation on theme: "CHAPTER 32 DISORDERS OF ENDOCRINE FUNCTION Essentials of Pathophysiology."— Presentation transcript:

1 CHAPTER 32 DISORDERS OF ENDOCRINE FUNCTION Essentials of Pathophysiology

2 PRE LECTURE QUIZ TRUE/FALSE  Hypopituitarism is characterized by a decreased secretion of pituitary hormones.  Hypothyroidism is evidenced by an increased metabolic rate, restlessness, irritability, tachycardia, diarrhea, and heat intolerance.  Primary adrenal insufficiency, or Addison disease, is caused by destruction of the adrenal gland.  Moon facies, buffalo hump, obesity, amenorrhea, and increased facial hair are manifestations of Cushing syndrome.  Addison disease is a temporary condition. T F T T F

3 PRE LECTURE QUIZ  In children, _____________ hormone deficiency interferes with linear bone growth, resulting in short stature or dwarfism.  When growth hormone excess occurs in adulthood or after the epiphyses of the long bones have fused, the condition is referred to as ______________.  Precocious ______________ is the early activation of the hypothalamic-pituitary-gonadal axis, resulting in the development of appropriate sexual characteristics and fertility.  ______________ disease is a state of hyperthyroidism that is often accompanied by goiter and exophthalmos.  ______________ syndrome refers to the manifestations of excess cortisol. Acromegaly Cushing Graves growth puberty

4 HYPOTHALAMUS- PITUITARY AXIS  Releasing hormones from hypothalamus tell the pituitary what to release into the blood  Trophic hormones from the pituitary tell specific peripheral glands to grow and produce their hormones Releasing Hormones Trophic Hormones

5 Primary: abnormality in the gland Secondary: abnormality in stimulation from the pituitary Tertiary: abnormality in stimulation from the hypothalamus HORMONE DISORDERS

6 PITUITARY HORMONES Growth hormone FSH and LH ACTH TSH stimulate gonads stimulates thyroid stimulates adrenal cortex

7 QUESTION Which hormone(s) stimulate the ovaries and testes? a. GH b. FSH and LH c. TSH d. ACTH and GH

8 ANSWER b. FSH and LH Rationale: Gonads are sex organs (ovaries and testes). These organs are stimulated by follicle- stimulating hormone (FSH) and luteinizing hormone (LH).

9 THE HYPOTHALAMUS CONTROLS GROWTH HORMONE RELEASE  GH secretion stimulated by:  Hypoglycemia, fasting, starvation  Stress  GH inhibited by:  Increased glucose levels, free fatty acid release, and obesity  Cortisol GHRH stimulates Somatostatin inhibits Hypothalamus Anterior pituitary Growth hormone GHIH Next Slide

10 GROWTH HORMONE SITIMULATED BY ?  Hypoglycemia, fasting, starvation, Stress ??  It would seem that adequate energy supply would be needed for Growth ?  A baseline level of GH exists during normal nutrition mildly stimulated by Deep Sleep, Exercise, and Protein Consumption. GH stimulates IGF-1  During fasting etc. and increased release of GH occurs due to a decrease in GHIH.  This produces a protective effect preventing muscle wasting by stimulating lipolysis and FFA metabolism maintaing blood glucose for the CNS  Without GH significantly more muscle wasting occurs

11 FUNCTIONS OF GROWTH HORMONE Promotes Growth Inhibits Insulin

12 GROWTH HORMONE DEFICIENCY  Idiopathic GH deficiency  Lacks hypothalamic GHRH  Pituitary tumors, agenesis of the pituitary  Cannot produce GH  Laron-type dwarfism  Hereditary defect in IGF production

13 GROWTH HORMONE EXCESS  In childhood: gigantism  In adulthood: acromegaly

14 QUESTION Tell whether the following statement is true or false. GH deficiency may result in dwarfism.

15 ANSWER True Rationale: Laron-type dwarfism is caused by a genetic inability to produce normal amounts of GH. Not True. Normal GH abnormal IGF

16 THE HYPOTHALAMUS CONTROLS GONADAL HORMONE RELEASE  Excessive GnRH secretion can be stimulated by:  Hypothalamic tumors  Pituitary tumors  Giving high levels of GnRH causes the pituitary to become less responsive and reduces the effects of abnormal GnRH secretion GnRH stimulates hypothalamus anterior pituitary FSH production of gametes and gonadal hormones LH

17 THYROID CONTROL  Thyroid releases T 3 and T 4  Both are carried by binding proteins  T 3 stimulates metabolism  T 4 is inactive until converted into T 3 in the tissues  Both exert negative feedback on the hypothalamus Why?

18 THYROID INSUFFICIENCY DUE TO LACK OF I  T 3 and T 4 are not made  There is no negative feedback to the hypothalamus  TRH and TSH continue to be made  If it is able, the thyroid will grow in response to the TSH

19 THYROID IMBALANCES  Hypothyroidism  Congenital  Acquired º Hashimoto thyroiditis º Thyroidectomy  Hyperthyroidism (thyrotoxicosis)  Graves disease  Thyroid tumors

20 QUESTION Tell whether the following statement is true or false. Simple goiter is caused by increased production of thyroid hormone.

21 ANSWER False Rationale: Simple goiter is the result of iodine ( I ) insufficiency. Since I is necessary in order to produce thyroid hormone, a deficiency results in low serum levels of T 3 /T 4. This causes TSH to stimulate the thyroid gland to make more hormone (which it cannot do because it needs I ). The cells of the thyroid gland hypertrophy in an effort to function (make thyroid hormone).

22 MAJOR ADRENAL CORTICAL HORMONES Cortisol What can cause Cortisol Stimulation? Hypothalamus releases ?? Causes the Anterior Pituitary to release ?? Causes the adrenal cortex to release ??

23 MAJOR ADRENAL CORTICAL HORMONES Negative feedback Negative feedback Hypothalamus Corticotropin-releasing hormone (CRH) Anterior pituitary Adrenal corticotrophic hormone (ACTH) Adrenal cortex Cortisol AldosteroneTestosterone

24 ACTIONS OF CORTISOL cortisol Increases catabolism blood glucose increased muscle breakdown plasma proteins increased free fatty acids increased SNS response increased immune/ inflammatory systems suppressed

25 ADRENAL CORTICAL DISORDERS  Adrenal cortical insufficiency: inability to make all three hormones  Primary adrenal cortical insufficiency (Addison disease)  Secondary adrenal cortical insufficiency  Acute adrenal crisis  Excessive adrenal secretion  Glucocorticoid hormone excess (Cushing syndrome)  Hyperaldosteronism  Congenital adrenal hyperplasia  Decreased cortisol synthesis; other hormones may be increased or decreased

26 CLINICAL MANIFESTATIONS OF ADDISON DISEASE ( CHRONIC ADRENAL INSUFFICIENCY)

27 CLINICAL MANIFESTATIONS OF CUSHING SYNDROME (HIGH LEVELS OF CORTISOL IN THE BLOOD)

28 SCENARIO Three men have adrenal problems.  One has hypoaldosteronism, one has an inability to make cortisol, and one has an inability to make testosterone. Question:  Which of them is most likely to develop:  Hypotension?  High CRH levels?  Hypoglycemia?  Hypervirilization?  Decreased libido?  Hyperkalemia?

29 SCENARIO Two women have benign pituitary tumors.  One woman has lost weight and complains of being hot all the time; she presents as thin and nervous, with tachycardia and exophthalmos  The second woman has gained weight in her abdomen and presents with a round face and thin arms and legs with stretch marks; she says that at her last checkup her doctor told her she was prediabetic Question:  What hormones are being secreted by the pituitary tumors in these patients? Why?


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