Presentation on theme: "Botulinum toxin in Ophthalmic Practice"— Presentation transcript:
1Botulinum toxin in Ophthalmic Practice Dr Sunayana BhatConsultantPaediatric ophthalmology , Strabismus and Neuro ophthalmologyVasan eye care , MangalorePh :
2Botulinum toxin injections are the fastest-growing cosmetic procedure all over the world Neurotoxin : Bacterium “Clostridium botulinum”'botulus' sausageGerman physician who described thepoisoning after the ingestion of sausage.
3Mechanism of actionActivity and dosingClinically available formsUsesComplications
4Mechanism of action Heavy chain of 100 kDa Light chain of 50 kDa kDa core type A molecule
5Mechanism of actionENDOCYTOSISSUBSTRATE MODIFICATION
6Mechanism of action Differ in SNARE protein / cleavage site A,B,C,D,E,FPROCESS OF FUNCTIONAL RECOVERYSprouting of nerve fibers from the terminal axonsExtra junctional Ach receptors
7Activity and Dosing1 unit : LD50 female swiss webster mice , intra peritoneal injection1 unit : 0.05 ng of toxinStored dryReconstitution with saline5-10 u : 0.1 ml