Presentation on theme: "Botulinum toxin in Ophthalmic Practice"— Presentation transcript:
1 Botulinum toxin in Ophthalmic Practice Dr Sunayana BhatConsultantPaediatric ophthalmology , Strabismus and Neuro ophthalmologyVasan eye care , MangalorePh :
2 Botulinum toxin injections are the fastest-growing cosmetic procedure all over the world Neurotoxin : Bacterium “Clostridium botulinum”'botulus' sausageGerman physician who described thepoisoning after the ingestion of sausage.
3 Mechanism of actionActivity and dosingClinically available formsUsesComplications
4 Mechanism of action Heavy chain of 100 kDa Light chain of 50 kDa kDa core type A molecule
5 Mechanism of actionENDOCYTOSISSUBSTRATE MODIFICATION
6 Mechanism of action Differ in SNARE protein / cleavage site A,B,C,D,E,FPROCESS OF FUNCTIONAL RECOVERYSprouting of nerve fibers from the terminal axonsExtra junctional Ach receptors
7 Activity and Dosing1 unit : LD50 female swiss webster mice , intra peritoneal injection1 unit : 0.05 ng of toxinStored dryReconstitution with saline5-10 u : 0.1 ml