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A Biomimetic Electrostatic Imaging System Proposed for Real-time In-vivo Surgical Guidance of Tumor Resection Jonathan Friedman, PhD, Peyman Golshani,

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Presentation on theme: "A Biomimetic Electrostatic Imaging System Proposed for Real-time In-vivo Surgical Guidance of Tumor Resection Jonathan Friedman, PhD, Peyman Golshani,"— Presentation transcript:

1 A Biomimetic Electrostatic Imaging System Proposed for Real-time In-vivo Surgical Guidance of Tumor Resection Jonathan Friedman, PhD, Peyman Golshani, MD/PhD, Mani Srivastava, PhD Networked and Embedded Systems Laboratory / Golshani Laboratory for Neuroscience --- University of California, Los Angeles. Contact Information Jonathan Friedman, PhD – Peyman Golshani, MD/PhD – Mani Srivastava, PhD – Networked and Embedded Systems Laboratory (NESL) Golshani Laboratory for Neuroscience Golshani Lab Department of Neurology David Geffen School of Medicine, UCLA Mark M. Souweidane, MD NewYork-Presbyterian Hospital/Weill Cornell Medical Center Future Work: Reduce Size and Scale of Electrodes Results: World’s First Biomimetic Electrostatic Imager The Problem: “Inoperable” Brain Tumors Proposed Approach: Biomimetic Electrostatic Imaging Generating the Background Field (in the Ocean) Modeling the Disturbance Field Background Field Conductive Object (Induced Dipole) In Field Disturbance Field Caused by Object Disturbance as Observed by Different Electrode Pairs “Electric” Fish Detect Changes to a Self- Generated Electric Field Calibration and Compensation Expected Observed Calibration Compensation Induced Dipoles Rotate in the Field Model is Fit to Tank Measurements Custom Gantry & Cantilever “Large” Scale Target Tank Trials Metal Pipe (Target) Gantry Moves Target Imager’s Electrodes Each Card Supports 17 Electrodes 68 Total Electrodes Multiple BEI Units Can Connect to the Same Host Inexpensive Disposable Flex-PCB Electrodes High Density AlphaSTAR Coated Electrodes Preparing for Real-time Imaging in Awake Behaving Animal Models 2-Photon uScope Provides Reference Craniotomy for Electrode Access Rig Images Courtesy Jiyoung Park World’s First 16 Electrode BEI Images Pipe Target Nearing Edge of Electrode Array – Accuracy Degrades Actual Location of Pipe Target (Yellow Circle) Actual Location of Pipe Target (Yellow Circle) Cross Section View of Tank at Depth Pipe Target Beyond Sensor Array – Accuracy Degrades Substantially White Pixels Show Areas of Increased Conductivity Real-time Functional Imaging of Cardiac Conduction ABSTRACT: Electric Field Disturbance Imaging Conductivity of Tumor Tissue is  10x Lower than Normal Brain Tissue The Brain! State of the Art Neuroprobes Destroy Tissue and Cannot Image Goal: Provide Simultaneous Real-Time Functional and Anatomical Imaging of Brain Tissue Using Quasi-Static Electric Fields Current Proposed Determine Spatial Conductivity of Tissue from Disturbance to Self- Generated Electric Field (like MRI) Surface Probe (non-destructive) Tumor Clearly Visible on MRI, BUT… …MRI Structure and RF Transducers Preclude Real-time Use in OR Stereotactic Camera Systems Register the Patient to the MRI – ineffective once the tissue resection begins Better Boundary Guidance Would Yield Better Outcomes & Enable Resections Currently Considered Too High Risk The Same Approach Could Be Used to Visualize the Conductive (Purkinje) Fibers -- Reducing 8 Hour Guess-and- Check Catheterization Lab Procedures to Less Than One Hour While Guaranteeing Efficacy of Treatment Fluroscope Imagery is Non-Functional and Cannot Visualize the Relevant Anatomy Fluroscope Uses Ionizing Radiation – Proposed Approach is Intrinsically Safe o >10,000 Sample Points o Over 6 Hours of Measurement o Highest Resolution Study Published o >10,000 Sample Points o Over 6 Hours of Measurement o Highest Resolution Study Published


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