Presentation on theme: "Karen Estrella-Ramadan 07/03/12"— Presentation transcript:
1Karen Estrella-Ramadan 07/03/12 BOARD REVIEW id part 1
2Question 1A family comes to your office for consultation regarding a 3-week trip to India they are planning to take in 3 months. The children, a 9-year-old boy and a 7-month-old girl, are well, and their immunizations are up to date. Of the following, the MOST appropriate prophylaxis to provide in preparation for travel is:chloroquine for both childrenhepatitis A vaccination for both childrenmeasles vaccination for the girlpolio vaccination for the boytyphoid vaccine for both children
3CMeasles: common in many parts of the world, including India. Measles vaccine is recommended for 6- to 11-month-old children, and the 7-month-old girl in the vignette should be given a dose of measles vaccine. She still will require two doses of measles-containing vaccine after 1 year of age because the immune response may be suboptimal at her young age. If the 9-year- old boy is up to date on immunizations, he requires no additional measles vaccination.
4Polio : NO, both are UTD in vaccines Chloroquine : NO, because South and Southeast Asia, sub- Saharan Africa, and tropical areas of South America are resistant to it. In these areas use atovaquone/proguanil and mefloquine. Doxycycline can be used in children older than 8 years of age.Travelers' Health – CDCHepatitis A: is a concern, but NOT approved in kids <1y/o. Iunder this age may use: Immunoglobulin IM.The boy must get vaccine 2-4 wks before departure if hadnt got it, and then sec dose in 6-12months.Polio : NO, both are UTD in vaccinesTyphoid: may be indicated for a trip to Indica longer than 2 wks, but neither of the two licensed vaccines is indicated in children younger than 2 years of age
5Question 2You are called by a nurse who has sustained a needle stick injury while drawing blood from a patient's central line. The patient is a 14-year-old male who recently was diagnosed with acute myelocytic leukemia. He has received several blood product transfusions for anemia and thrombocytopenia. You obtain human immunodeficiency virus and hepatitis C serologies. Of the following, the additional serologic test that MUST be obtained for the nurse is for:Cytomegalovirushepatitis Ahepatitis Bmeaslestetanus
6C Requires a serologic test for hepatitis B. Hepatitis B virus (HBV) is a DNA hepadnavirus that is comprised of an outer lipoprotein envelope containing hepatitis B surface antigen (HBsAg) and an inner nucleocapsid consisting of hepatitis B core antigen.ONLY antibody to HBsAg (anti-Hbs) provides protection from HBV infectionTransmitted through: blood or body fluids (wound exudates, semen, cervical secretions, and saliva)Blood and serum highest concentrations of virus; salivalowest.Serology is the most common diagnostic test used to detect and diagnose hepatitis B.In addition, hybridization assays and gene amplification techniques (eg, polymerase chain reaction) are available to detect and quantitate HBV DNA.
8Cytomegalovirus, hepatitis A, and measles are NOT transmitted parenterally. Tetanus is acquired through contamination of wounds with soil or excrement that contain the tetanus organism. Needlestick injury is not a usual pathway for acquiring tetanus.
9Question 3A 15-year-old girl presents to the emergency department with right upper quadrant pain for 2 days that is severe enough to keep her out of school. Her appetite is decreased and she has nausea but no vomiting or diarrhea. She has mild discomfort with urination but no vaginal discharge. The only medication she is taking is combined oral contraceptive pills. Her last menstrual period was heavier that usual. Laboratory tests reveal: WBC: 7.4x103/mcL (7.4x109/L) with N: 64% L: 26%Total bilirubin, 0.4 mg/dL (6.9 mcmol/L)ALT: 14 units/LAST: 16 units/LUrine has 7 WBC.Abdominal US: reveals a normal liver, spleen, gallbladder, and kidneys.Of the following, the MOST likely diagnosis isCholecystitisFitz-Hugh-Curtis syndromehepatitis A infectioninfectious mononucleosispyelonephritis
102ALL adolescents should be asked annually about: sexual behaviors , unintended pregnancy and sexually transmitted infections (STIs), including HIV.Document screening and LMPFitz-Hugh-Curtis syndrome or perihepatitis presents as RUQ pain that results from inflammation of the liver capsule from ascending pelvic infection. Although typically associated with salpingitis, it can exist without other signs of pelvic inflammatory disease and may mimic other abdominal emergencies.
11Lab r/o hepatitis, including that caused by mononucleosis, and biliary tract obstruction. The absence of fever and the location of pain for this girl make pyelonephritis unlikely.Pyuria raises the possibility of urethritis, which commonly occurs with Neisseria gonorrhoeae and Chlamydia trachomatis infections. C trachomatis can cause inflammation of the genital tract without the classic symptoms and signs of pelvic inflammatory disease. Often, heavier menstrual flow may be the only symptom.
12Question 4A 15-year-old boy comes to the emergency department because of cramping abdominal pain, diarrhea, and body aches. Physical examination reveals no icterus or organomegaly, although he has increased bowel sounds and mild diffuse abdominal tenderness. His genitalia are at Sexual Maturity Rating 4. Among the results of laboratory tests obtained are:Total bilirubin, 0.6 mg/dL (10.3 mcmol/L)ALT: 18 units/LAST: 22 units/LAlkaline phosphatase: 360 IU/LOf the following, the MOST likely explanation for the results of these laboratory tests is:bone malignancyinfectious hepatitisinflammatory bowel diseasephysiologic growth spurtviral gastroenteritis
13DAn increased serum alkaline phosphatase value on a LFT panel in an adolescent, often is the result of rapid bone growth during the pubertal growth spurt. Therefore, it is important to correlate the value with the Sexual Maturity Rating (SMR) rather than with chronologic age.The highest mean SAP concentrations in girls occur at SMR 2 and in boys at SMR 3, coinciding in each instance with peak height velocity and presumed maximum osteoblastic activity. (high as 500 UI/L)Osteoblasts, by creating a local environment of alkalinity via alkaline phosphatase, help build bone.With increasing SMR or age, the SAP values in both sexes decrease markedly.The normal range for children and adolescents varies with age, sex, sexual maturity, and reference laboratory.The isoenzyme test can reveal whether an elevation of SAP is from bone or liver, but this test is not widely available.
15Pathologic causes of increased SAP include: Liver or biliary diseasePregnancydrugs (eg, phenytoin)skeletal diseaseendocrine disorders such as hyperPTH.Normal concentrations of liver enzymes suggest a nonhepatic cause of SAP elevation and rule out infectious hepatitis and inflammatory bowel disease with hepatic involvement.Bone pathology (eg, osteosarcoma) presents with higher SAP values than reported for this boy along with other symptoms (eg, limb pain) and signs (eg, swelling).Elevated SAP concentrations do not occur in viral gastroenteritis.
16Question 5You are evaluating an 18-month-old boy in the emergency department who appears "toxic" and is sitting uncomfortably and leaning forward in his mother's lap. His temperature is 40.0°C, heart rate is 140 beats/min, respiratory rate is 35 breaths/min, blood pressure is 90/60 mm Hg, and oxygen saturation on room air is 94% by pulse oximetry. He is drooling from the corners of his mouth, and his cry appears muffled. The nurse shows you the lateral neck radiograph that was just obtained. Of the following, the MOST appropriate next step in the treatment of this patient is
18administration of intramuscular penicillin blood cultures and a complete blood countemergent otolaryngology and anesthesia consultationintramuscular administration of dexamethasonethroat culture
19CEpiglottitis is a medical emergency. The incidence of this disease has significantly decreased since the introduction of the Haemophilus influenzae type b vaccine, and the most common infectious pathogens now are Streptococcus pneumoniae, group A beta-hemolytic Streptococcus, and Staphylococcus aureus.Often, the infection involves the entire supraglottic area, not just the epiglottis, and is called supraglottitis.Typically between 2 and 8 years of age, usually present with the rapid onset of fever, sore throat, and the "four Ds" (drooling, dysphagia, dysphonia, and dyspnea), "tripod position." Clinicians must be vigilant for atypical presentations, especially among children younger than 2 years of age.
20AIRWAY!!! Direct examination of the airway under anesthesia An ETT that is 0.5 to 1 mm smaller than usual for age generally is needed.Cultures of the supraglottic area can be obtained at the time of intubation and broad-spectrum antibiotics: CTX.Lateral radiographs are diagnostic but should be deferred until personnel and equipment ready for airway security. As well as lab work, throat cx or IM meds.Neither penicillin nor dexamethasone is indicated for the initial treatment of epiglottitisRifampin for 4 days for alll close contacsChildren >2y/o no need for vaccine
21Question 6A 13-year-old girl who plays soccer presents with a temperature to 38.9°C for 2 days, dysphagia, malaise, and nausea. She has had no cough or rhinorrhea. Physical examination reveals erythema of the tonsils with petechial hemorrhages, petechiae on the soft palate, mild enlargement of the cervical lymph nodes, and vague discomfort in the epigastric area. On evaluation, you palpate a spleen tip. You obtain a rapid streptococcal antigen test and a throat culture. The rapid streptococcal antigen test is negative and you recommend antipyretics and rest. She returns to the clinic 48 hours later because her symptoms have not improved. The throat culture is negative, but the girl reports continued fever, increasing malaise, and some vomiting. Findings on the physical examination have not changed, and there are no signs of serious bacterial infection or dehydration. Of the following, the MOST efficacious next test for this patient is:CBCEpstein-Barr virus titersrapid influenza testspot test for infectious mononucleosisviral culture for adenovirus
22DCriteria for streptococcal pharyngitis fever, sore throat, tender cervical lymphadenopathy, and NO cough.70% of cases of exudative pharyngitis are due to virus.Petechiae on the soft palate may be a sign of group A streptococcal pharyngitis, but macules, vesicles, and other lesions of the palate also are seen in EBV, coxsackie and adenoAdenovirus : 25% of exudative pharyngitis, often with conjunctivitis.Enterovirus: pharyngitis, gastrointestinal complaints, and vesicular lesions of the pharynx, often including the palate.Arcanobacterium haemolyticum : bacterial cause of pharyngitis similar to by group A Streptococcus. Adolescents.
23EBV: pharyngitis + more serious illness hepatosplenomegaly, hepatitis, or significant lymphadenopathy.Abdominal pain may be seen with streptococcal disease, Epstein- Barr virus infection, and a variety of other illnesses.R/o Kawasaki disease in the child who has fever and oral mucous membrane changes, especially with rash and adenopathy, as well as adenovirus and common rhinoviruses and influenza. For the girl described in the vignette, the heterophile antibody rapid mononucleosis spot test is likely to be helpful because it is widely available and results can be obtained quickly.If results are negative and clinical suspicion for this infection remains high, Epstein-Barr virus titers may be obtained.Standard adenovirus culture takes time, no fastest than 2 days , not readily available, and it can be in tonsills for months post infection.A haemolyticum may be cultured with conventional throat culture, but the laboratory must be informedThe absence of cough or coryza in this patient makes Flu less likely.CBC not specific
24Question 7A 7 year-old-girl presents to your office with a 1-day history of a temperature of 38.9°C. Notable findings from her past medical history include static encephalopathy, seizure disorder, and recurrent urinary tract infections. She is receiving intermittent straight catheterization and trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis. Her medications also include phenytoin, albuterol via nebulizer, ipratropium, and ranitidine. Urinalysis reveals more than 100 white blood cells per high-power field and is positive for leukocyte esterase and nitrites. Of the following, the BEST option for oral empiric therapy pending culture results isAmoxicillinazithromycinciprofloxacinNitrofurantointrimethoprim-sulfamethoxazole
25CRecurrent UTI under TMP-SMX prophylaxis resistant pathogen , making ciprofloxacin,, the best option for therapy, pending cx and sensitivities.Azithromycin is not indicated for treatment of UTIs.Amoxicillin and nitrofurantoin not for resistant pathogen and no TMT-SMX because of resistance in this childStudies in young animals demonstrated arthropathy, but no increase incidence in pediatric ptsThe Committee on Infectious Diseases of the AAP suggest that fluoroquinolone use in pediatrics be restricted to situations in which the pathogen is multidrug-resistant and there is no safe and effective alternative or when parenteral therapy is not feasible and there is no effective alternative oral agent. Such situations might include UTIs caused by multidrug-resistant gram-negative rods, including Pseudomonas aeruginosa; gastrointestinal and respiratory tract infections caused by resistant gram- negative organisms; and chronic or acute osteomyelitis caused by P aeruginosa. In addition, a fluoroquinolone may be indicated for treatment or prevention of anthrax and for treatment of mycobacterial infection with sensitive strains. Be aware of interactions: antiacids containing aluminum , Mg or Calcium—decrease absorption of cipro, NSAIDS potentiate CNS side effectsCipro increases warfarin, inhibit K channels in heart and can cause long QT interval, hypo or hyperglicemia in pts with insulin
26Question 8An 18-month-old boy is brought to the clinic with fever and irritability. His mother explains that he has had a fever for the past week and a red rash on his extremities. On physical examination, he has a temperature of 39.2°C; he is irritable; his eyes are injected without discharge and his lips are dry, red, and cracked. All other findings are within normal limits. Of the following, the MOST appropriate next step in this patient's care is to:administer intravenous antibioticsadminister intravenous gamma globulinobtain blood culturesobtain electrocardiographyperform a lumbar puncture and culture the cerebrospinal fluid
28Vasculitis of small- and medium-sized blood vessels, including the coronary arteries. 80% of cases occur in children <4y/o> in winter and spring, > in malesAll ethnicitiesPhases: ACUTE: 1-2 wks after onset of fever and is when the diagnostic criteria typically are present.SUBACUTE: 2 to 8 weeks after disease onset, and patients may demonstrate desquamation of the fingers and toes.Coronary aneurysms may develop, particularly in those who have not been treated with intravenous gamma globulin during the acute phase.CONVALESCENT: lasts for months following the illnessBecause the child in the vignette is in the acute phase of KD, he should be treated with intravenous gamma globulin at a dose of 2 g/kg. If his fever persists, a second dose of gamma globulin may be administered. In addition, high-dose aspirin therapy (80 to 100 mg/kg per day) is administered until the patient is afebrile for 48 hours, at which time the dose is decreased to 3 to 5 mg/kg per day for 6 to 8 weeks or until the platelet values normalize. NO ABX, NO LP , NO EKG
29Question 9A 16-year-old girl comes to your office in August for evaluation of fever, headache with retro-orbital pain, and marked achiness of her joints and muscles. She returned 1 week ago from a church mission trip to El Salvador. A number of other people on the trip were diagnosed with a viral syndrome. Findings on physical examination are normal except for: T 39.1°C, HR: 104:Conjunctival injection without dischargeErythema of the pharynx without exudateMild, tender hepatomegalyMaculopapular rash on the trunk and scattered petechiaeLaboratory results include: WBC: 3.2x109/L, Hb: 14, hct: 41.8%, platelets: 78AST: 212 units/L, ALT: 187 units/L, Total bilirubin: 0.8 mg/dLBUN: 18.0 mg/dL, creatinine: 0.8 mg/dLOf the following, the MOST likely diagnosis is:
30dengue feverEpstein-Barr virus infectionhepatitis A infectionMalariatyphoid fever
31Abreak-bone fever."Dx: serologyDengue virus is the most common arthropod-borne (arbo) virus disease in the world,Dengue fever has been reported in Southeast Asia, the South Pacific Islands, Latin America, and the Caribbean.Humans: accidental hostsretro-orbital pain, conjunctival injection, pharyngeal erythema, hepatomegaly with mild elevation of liver enzyme values, thrombocytopenia, and recent travel to El Salvador
32AArbovirus: US: summer and autumn CNS involvement: West Nile virus, eastern and western equine encephalitis virus, St Louis encephalitis virus, LaCrosse encephalitis virus, and Japanese encephalitis virus. Other arthropod-borne illnesses include hemorrhagic fevers and febrile illnesses, often with rashes or hepatitis. Dengue fever is the most prominent of such infections. Others include Colorado tick fever and yellow fever
33Infectious mononucleosis or acute Epstein-Barr virus infection can cause many of the symptoms and laboratory abnormalities (thrombocytopenia, elevated liver enzymes) described in the vignette, but the absence of splenomegaly and exudative pharyngitis and the extent of the myalgias and arthralgias are less typical of this condition.Similarly, the degree of systemic complaints is not consistent with hepatitis A infection.Malaria can present with many of the features described for this girl, but the degree of myalgias and arthralgias is somewhat severe for non-falciparum malaria, which are the types seen in Central America. In addition, anemia, hypersplenism, and pallor would be present in malaria.Furthermore, the viral illnesses reported in other members of the group are more consistent with a viral diagnosis than malaria.Typhoid fever also may manifest many of the complaints described for this girl, but the rash of typhoid (rose spots) is much more subtle, and abdominal pain generally is more prominent.
35QUESTION 10: A 15-year-old boy presents to the clinic because of a persistent cough. According to his mother, his cough has been present for approximately 2 weeks, but it seems to be getting worse. He does not cough all the time, but the coughing episodes tend to come in bursts. This morning she became very worried because he passed out during a coughing spell. Physical examination reveals a healthy-appearing male in no apparent distress. He is afebrile, and his vital signs are normal. He has petechiae on his face but no other skin lesions. His lungs are clear. Of the following, the MOST appropriate antimicrobial agent to prescribe for this patient is:azithromycinClarithromycinDoxycyclineErythromycintrimethoprim-sulfamethoxazoleCountdown10
36Pertussis (bordetella pertussis) Incubation: 3-12 days.A 6wk duration, with 3 stages lasting each one 1-2 wks.Stage 1: (catarrhal): URI symptomsVery contagiousStage 2: paroxysms of intense coughing lasting up to several minutes.Infants >6mo and toddlers: “whooping cough” cough, f/u by loud whoop as inspired air goes through a still partially closed airway.<6mo: apneic episodes and are at risk for exhaustion.Older children: Posttussive vomiting and turning red with coughingStage 3: chronic cough, which may last for weeks.Older children, adolescents, and adults may not exhibit distinct stages. Symptoms in these patients include uninterrupted coughing, feelings of suffocation or strangulation, and headaches.
37Dx: cough for >2wks + paroxysmal cough, posttussive vomiting, or inspiratory whoop Cx: nasopharyngeal swab for (15-30”) or until cough
38AAny patient who has episodic coughing that ends with syncope or vomiting consider pertussisComplications in adolescents: urinary incontinence, sleep interruption, rib fractures, and pneumonia.Despite vaccination: increase incidence in adolescentsAAP: booster TdapIf received only tetanus toxoid or only Td, GIVE Tdap if the interval since the Td is > 2 years or if the adolescent is living in a setting of increased disease, immunosupression or risk to transmit to a vulnerable contact
39Doxycycline is not recommended for the treatment of pertussis. Tx of pertussis after cough started DOESNT affect the course of the illness but limits the spread of disease to others.Macrolides: abx of choiceAzithromycinDoesn’t interact with drugs metabolized by citP450Less side effects compared to other abx from same familyTMT-SMX: if allergic to macrolides or macrolide-resistant isolate (child >2mo)Doxycycline is not recommended for the treatment of pertussis.
40Question 11 You are speaking to the mother of a child who attends a junior high school where one of the students was diagnosed with meningococcal disease 24 hours ago. Her child does not have any classes with the index patient and, except for passing him in the hall during lunch 3 days ago, has had no other contact with the patient. The child's mother is frantic because the school sent home a notice asking parents to bring their children to the public health department or their private physician to receive antibiotic prophylaxis. Of the following, the MOST appropriate advice for this parent is that her child:does not require antibiotic prophylaxis and does not need to be seendoes not require antibiotic prophylaxis but needs to be evaluated to determine if she is developing symptoms of meningococcal diseaseneeds to be seen to obtain nasopharyngeal cultures for meningococcal organisms and if the cultures are positive, may require antibiotic prophylaxisrequires antibiotic prophylaxis and should be seen immediatelyshould be seen immediately to determine if she needs to be hospitalized and treated for possible meningococcal diseaseCountdown10
41AClassroom contacts of students who have meningococcal disease, are considered CASUAL contacts (no history of direct exposure to the index patient's oral secretions), and the use of prophylactic antibiotics is NOT recommended.Prophylaxis:Close contacts of all persons who have invasive meningococcal disease, whether sporadic or in an outbreak, SHOULD receive chemoprophylaxis within 24 hours of diagnosis of the primary case, regardless of vaccination status.Close contacts include ALL household contacts, child care and nursery school contacts during the previous 7 days, persons who have had direct contact with the patient's oral secretions, and persons who frequently eat or sleep in the same dwelling as the index patient.In view of this and the fact that the contact is asymptomatic, she does not require medical evaluation at this time, and nasopharyngeal cultures are not indicated.
42Because secondary cases of meningococcal disease can occur several weeks after the onset of disease in the index case, the use of meningococcal vaccine is a possible adjunct to chemoprophylaxis if the serogroup is contained in the vaccine.Other infections can spread easily in the household setting and may require the use of postexposure prophylactic immunoglobulin, antibiotics, or vaccines to prevent development of disease in individuals exposed to the index case, such as:
44Question 12 A 2-year-old girl presents to the emergency department with a simple febrile seizure. After the recovering from their shock, the parents, who are medical students, ask you whether genetic predisposition or particular infectious agents confer risk for febrile seizures. You respond that several genes appear to increase risk for febrile and nonfebrile seizures, but certain infectious agents also may be more likely than others to trigger febrile seizures. Of the following, the agent that is MOST associated with febrile seizures is:Aspergillus fumigatusEscherichia coligroup A beta-hemolytic Streptococcushuman herpesvirus type 2human herpesvirus type 6Countdown10
45EFebrile sz:Common: 1mo to 5 years, often: presenting between 6 months and 3 years of age.> benignPredispositions are not fully characterized but include both genetic factors and types of infectionsURI, AOM, roseola (HHV 6)HSV 2, group A beta-hemolytic streptococcal infection, aspergillosis, and Escherichia coli infections have NOT been linked to febrile seizures.
46Question 13A 9-year-old girl presents to the ED because of fever, a macular rash on her trunk and arms, and pain in her knees and ankles. Her mother explains that she recently had pharyngitis. You note a murmur on physical examination and order electrocardiography and echocardiography. The echocardiogram demonstrates mitral regurgitation.
48Of the following, the MOST likely diagnosis for this girl is: acute rheumatic fevercat-scratch diseaseEpstein-Barr viral infectionLyme diseaseSLECountdown10
49AThe girl described in the vignette has three of the five major Jones criteria for the diagnosis of acute rheumatic fever.Complications::Carditis: lead to mitral and ocassional aortic regurgitation and stenosis.Migratory arthritis and chorea will resolve with no problemsBest evidence of strep infection: elevated ASO or antiDNAase B titer.Tx: steroids if severe carditis leading to CHF.; unclear if reduces long term valve dysfunction. ASA can shorten acute symptoms, but unclear if decrease the risk of serious lifelong rheumatic heart disease.The MOST important chronic therapeutic intervention is antibiotic prophylaxis to prevent group A streptococcal pharyngitis, which can lead to a recurrent bout of acute rheumatic fever. Serious valve damage is unusual after the initial attack of acute rheumatic fever but becomes more likely with subsequent attacks.Administration of intramuscular benzathine penicillin every 21 to 28 daysRheumatic fever prophylaxis must continue into adulthood.
50Jones criteria: ARF (2 major OR 1 major and 2 minor, + evidence of a preexisting Group A hemolytic streptococcal infection)
51Why not?Cat-scratch disease : by Bartonella. Most commonly in children 1 to 2 weeks following a cat scratch or bite. Common findings are lymphadenopathy, headache, chills, and abdominal pain. The disease usually resolves spontaneously, with or without treatment, in 1 month. Cardiac valve involvement and electrocardiographic changes are rare.
52Why not?EBV infection infectious mononucleosis, which develops when a person initially is exposed to the virus during or after adolescence. Symptoms : fever, pharyngitis, hepatitis, and lymphadenopathy. Usually, laboratory tests are needed for confirmation. Serologic results include an elevated white blood cell count, an increased percentage of certain atypical white blood cells, and a positive reaction to a "mono spot" test. Pericarditis and myocarditis are infrequent findings. The young age of the patient in the vignette is highly unusual for symptomatic Epstein-Barr virus infection, as are the electrocardiographic changes, rash, and arthritis.
53Why not?Lyme disease results in fever, rash, malaise, and muscle soreness. Although neurologic disorders and arthritis can occur, these are invariably late findings. In addition, the morphology of the rash distinguishes this condition from acute rheumatic fever, and the Jones criteria are not fulfilled. Carditis is a rare manifestation of Lyme disease. The most common abnormality is atrioventricular block of various degrees, although other rhythm abnormalities have been reported. Pericarditis, myocarditis, cardiomyopathy, and degenerative valvular disease have been associated with Borrelia burgdorferi infection.
54Why not?Systemic lupus erythematosus (SLE) can present with rash, carditis, and arthritis. However, evidence of a preexisting group A hemolytic streptococcal infection would not be expected. Of course, this laboratory finding could be present in a patient who has SLE, but these two diagnoses can be distinguished by the additional laboratory findings in SLE, including antinuclear antibody, anti-double-stranded DNA antibodies, and low complement values.
55Question 14A 14-year-old otherwise healthy boy developed an oval pink, scaly lesion on his back about 1 week ago. He presents today with widespread, moderately pruritic, scaling macules involving his trunk and upper extremities but sparing the scalp, face, palms, and soles. He admits to being sexually active but has no other known exposures and takes no medications. Aside from the rash, physical examination findings are normal.
57Of the following, the MOST appropriate next step in management is to: obtain serology for Mycoplasma and Legionellaobtain serology for syphilisperform a skin biopsyprescribe a course of azithromycinprescribe a topical antifungal creamCountdown10
58This pt has: PYTIRIASIS ROSEA! INFLAMMATORY SKIN CONDITION, MOSTLY ADOELSCENTS, OF UNKNOWN ETIOLOGYPRODROME: URILATER: HERALD PATCH: 2-10cm oval, red flat, scale, can get confused with tinea corporis or atopic dermatitis.THEN: 2-21 days after the appearance of the herald patch, crops of 5- to 10-mm oval, salmon-colored thin plaques appear. These range in number from less than 50 to more than 200 on the body. They are classically distributed along Langer's lines, producing a Christmas (fir) tree pattern on the back . They also may appear transversely across the lower abdomen and back, circumferentially around the shoulders, or in a V-shaped pattern on the upper chest.African-american: more in faceRESOLVES: in 2-12wks? Association with HHV-7, Legionella, Mycoplasma.
59BAmong the most important differential diagnoses for pityriasis rosea is secondary syphilis, especially is rash on palms and soles.In rare occasions when rash doesn’t resolve, consider skin bx.TX for pytiriasis rosea;Pruritus: emollientsNo evidence of improvement with topical antifungal? With macrolides help decrease duration of disease
60Question 15: A 14-month-old boy presents to the emergency department for evaluation of respiratory distress, recent fever, cough, and congestion. He has received all of his vaccinations. Physical examination shows tachycardia, poor perfusion, and hepatomegaly. CXR documents an enlarged heart with hazy lung markings. Electrocardiography reveals sinus tachycardia. Echocardiography identifies severe left ventricular dilation and systolic dysfunction, with mitral regurgitation. You suspect dilated cardiomyopathy. Of the following, the MOST likely cause is:bacterial pneumonia leading to bacterial myocarditiscongenital coronary artery anomalyDuchenne muscular dystrophypreviously undetected supraventricular tachycardiaviral myocarditis due to enterovirusCountdown10
61E Myocarditis, most often is due to infection from common viruses. Inflammationmyocite necrosis dilated cardiomyopathySymptoms: fever, chest pain, abd pain, peripheral edema, resp distress, liver congestion, palpitations.Toddlers: decrease po, cough, malaiseComplications: CHF, poor cardiac output, arrhythmias, pericarditis, deathSuspicion: elevated ESR, CRP, troponin, echo cardio + for LV dilatation, myocardial edema.Gold standard: myocardial bx.
62ETIOLOGY:INFECTIOUS:Enterovirus, coxsackievirus, adenovirus, parvovirus B19, HIV and cytomegalovirus.Bacterial causes are rare, except for patients who have immunodeficiency (Brucella, Corynebacterium diphtheriae, Haemophilus influenzae, and Borrelia burgdorferi (Lyme disease) as well as Fungal pathogensTOXINS:ethanol,CO, anthracyclines chemotherapy, some antipsychotics (eg, clozapine), and immunologic reactions to acetazolamide and amitriptylineAUTOIMMUNE: sleroderma, SLETreatment: symptomatic: inotropes, afterload reduction, diureticsHigh inflammatory markers: IVIG and steroidsMaintenance: ACE-captoprilCHF: heart transplant
63Congenital coronary anomalies can cause myocardial dysfunction and subsequent isquemia such as: coronary fistulaAnomalous coronary artery arising from the pulmonary arteryWill present with similar symptoms but no URI prodromeDuchenne muscular dystrophy results in a dilated cardiomyopathy, but changes until late childhood or early adolescence.Supraventricular tachycardia (in addition to all forms of atrial tachyarrhythmia) can cause a dilated cardiomyopathy if it is chronic
64Question 16: A 17-year-old girl has been hospitalized for 3 weeks due to complicated peritonitis following a ruptured appendix. She has undergone laparotomy and drainage of intra-abdominal abscesses and improved while receiving intravenous ampicillin, gentamicin, and clindamycin. Her nasogastric tube was removed last week, and she has been tolerating a bland diet. Today, however, she complains of abdominal pain and distention and has had three episodes of diarrhea. Physical examination reveals a febrile adolescent who has a diffusely tender abdomen. Of the following, the stool test MOST likely to establish the diagnosis is:bacterial cultureevaluation for ova and parasitesfecal occult bloodtoxin assayviral cultureCountdown10
65DLong course of IV abx + abd pain+ diarrhea = colitis sec to Clostridium difficile.Dx: stool for C difficile toxins (A and B).If sample will not be tested promptly, store it at 4°C (deteriorates at room temperature)Endoscopy: Pseudomembranes and friable colorectal mucosa.Occult blood would not be diagnosticA stool study for ova and parasites would not be useful because a patient who has been hospitalized for a prolonged period of time is unlikely to have developed a gastrointestinal tract infection due to a parasite.Nosocomial viral infections of the gastrointestinal tract do occur, and a stool viral culture may be appropriate but in this case, hx is more related to C diff.The spectrum of illness caused by C difficile ranges from asymptomatic carriage to watery diarrhea to pseudomembranous colitis.Asymptomatic carriage can occur at any age but is common in newborns and <1y/o .
66C diffSymptoms: fever, abdominal pain and cramps, and diarrhea and appear systemically ill.Complications: Toxic megacolon and intestinal perforationlikely to be fatal in infants who have underlying gastrointestinal disease (Hirschsprung disease or inflammatory bowel disease) or are immunocompromised.Risk factors : Abx therapy (especially beta-lactam drugs, clindamycin, fluoroquinolones, and macrolides ), BUT CAN HAPPEN WITH ANYONE), underlying bowel disease, gastrointestinal tract surgery, prolonged nasogastric tube insertion, repeated enemas, and renal insufficiency. Prolonged hospitalization, rooming with an infected patient, and being on the same hospital ward as a symptomatically infected patientPrevention: hand hygiene, limiting antibiotic use, properly disposing of contaminated materials, and adequately cleaning contaminated surfaces.Alcohol-based hand hygiene products and many common hospital disinfectants do not eradicate C difficile spores;USE SOAP AND WATERDiluted bleach solutions are best for cleaning and decontaminating surfaces.Excluded pt from group activities for the duration of the diarrhea.Tx: Metronidazole orally or intravenously is effective and the drug of choice.Oral vancomycin for patients who have severe disease or can be used alone for those who do not respond to metronidazole. Therapy should be administered for at least 10 days.
67Question 17: A 3-year-old boy developed a petechial rash beginning on his wrists and ankles 5 days after a family camping trip in the Chesapeake Bay area. A latex agglutination assay confirms the diagnosis of Rocky Mountain spotted fever. Of the following, the MOST appropriate antibiotic choice for treating this child is:AmoxicillinAzithromycinChloramphenicolDoxycyclinetrimethoprim-sulfamethoxazoleCountdown10
68DDoxycycline is the treatment of choicefor Rocky Mountain spotted fever (RMSF)Amoxicillin, azithromycin, and trimethoprim- sulfamethoxazole are not active against Rickettsia rickettsii, the etiologic agent of RMSF.Other uses for tetracyclines: chlamydial infections (eg, nongonococcal urethritis, pelvic inflammatory disease), Lyme disease, community-acquired MRSA Legionnaires disease, Mycoplasma infections, leptospirosis, chloroquine-resistant malaria, and traveler's diarrhea.
69Question 18: A 9 y/o boy has complained of stomach cramps and diarrhea for the past 3 days. Five days ago, he visited a dairy farm with his 4th grade class and drank unpasteurized milk. A fecal sample brought in by the parents demonstrates mushy stool, with flakes of mucus and blood. Findings on PE include a HR of 110, dry lips, mild and diffuse nonspecific abdominal tenderness; and active bowel sounds. You hospitalize the boy for administration of IVF and send a stool specimen for culture. Of the following, a TRUE statement about AGE is that:Cats and dogs are not at risk for human infection with enteric pathogensErythromycin shortens the duration of Campylobacter gastroenteritisRotavirus is a common cause of bloody diarrhea in infants and childrenThe incubation period for calicivirus (norwalk) is 5-7 daysTMP-SMX is the tx of choice for Giardia lambia infectionCountdown10
70B Or Campylobacter: improperly cooked poultry and … Acute onset of symptoms, unpasteurized milk consumption and stool findings= acute bacterial colitisCommon pathogens: Campylobacter, Salmonella, Shigella, Yersinia, E. coli, C. diff.> bacterial gastroenteritis have an incubation time of 1-7 days after exposureTransmission:Cats and dogs: giardiaTx with metronidazol or nitazonamideRotavirus: no blood, infantsNorwalk: incubation 12hrs-4 daysOther diff dx: IBD, HSP, vasculitis. Meckel and polyps: blood but painlessOrCampylobacter: improperly cooked poultry and …Erytho or azithro decrease duration of illnessIf stool + for C fetus: septisemia-meningitis: IV abx
72Question 19 A 5 y/o girl has been bitten on the hand by her cat Question 19 A 5 y/o girl has been bitten on the hand by her cat. Within 24hrs of the bite, she developed pain, edema and erythema at the bite site. Of the following, the MOST likely organism to cause the wound infection is:Alpha-hemolytic streptococcusBacteroidesFusobacteriumPasteurella multiocidaStaphyloccus aureusCountdown10
73D Bites: > dogs then cats Tx: But higher rate of infection (sharp teeth=puncture wound=deep inoculation)Tx:careful cleaningtetanus prophylaxis if requiredevaluation for need for rabies prophylaxisuse of abx if wound is infected
74Pasteurella multiocida Infection: quick <24hrs, erythema, tenderness and edemaTx: Augmentin-cover also for anaerobes and S. aureusDON’T USE: cephalexin, clinda, cefaclor, cefadroxil= resistantIf allergy to PCN: use TMP-SMX, cefuroxime
75Tetanus prophylaxis Wound Tetanus (3 doses) Tetanus unknown contaminatedNone (if last tetanus was <5yrs ago)TIG + TdapcleanNone ( if last tetanus was <10yrs ago)TdapDtap if < 7y/o
76Rabies prophylaxisTransmitted to humans and domestic animals from infected bats, raccoons, skunks, foxes, and coyotes.Mice and rabbits: rareTransmission: contamination of mucosa or skin lesions by saliva or neural tissue from the infected animal.Incubation period of the virus ranges from a few days to years but usually is 4 to 6 weeks.
77In cases where animal testing is not possible Give: rabies immune globulin (RIG) and rabies vaccine ideally within 24 hours of exposureGive RIG within 7 days:Protect against rabies between exposure and antibody productionTotal: 20 IU/kg of RIG, > around the wound, remaining, give IM at a distant site from the vaccine.
78Rabies vaccine1 mL IM dose in the deltoid muscle or the anterolateral thigh on the day of exposure or first day of postexposure prophylaxis (day 0) and is repeated on days 3, 7, and 14 after the initial dose in immunocompetent individuals.For immunosuppressed individuals, an additional 1.0-mL dose of vaccine should be provided on day 28 of postexposure prophylaxis.Documentation of seroconversion 1 to 2 weeks after the completion of prophylaxis is reserved for immunosuppressed persons.Animal Bite Report Form
79Question 20You are asked to attend the delivery of a term infant because the baby is SGA and prenatal US revealed periventricular cerebral calcifications. The infant’s bwt: 2 kg. On PE, you note HSM and a petechial rash on face and trunk.
81Of the following the BEST laboratory test for dx the cause of these findings is: Nasopharyngeal cx for HSVRPR for syphilisSerum IgG for rubellaSerum IgM for toxoplasmosisUrine cx for cytomegalovirusCountdown10
82E All viral specimens: transported on ice Easy to identify: adeno, HSV, VZV, CMV, entero, rhino, influenza, parainfluenza, RSVNewborns: asymptomatic: HSV, syphillisCerebral calcifications:NONE: Rubella-Cataracts + glaucoma tx: nonePERIVENTRICULAR: CMV-chorioretinitis tx? gancyclovirDIFFUSE: toxoplasmatx with pyrimethamine, sufadiazine, leucovorinAll have HSM and petechial rashNo hearing loss in toxoDx: CMV with urine cx
83Question 21 You are called to help manage a 2y/o girl who has relapse ALL and has developed enteroccal bacteremia. Initial susceptibility testing reveals that the pathogen is resistant to vancomycin. Upon further investigation, you discover that the infecting organism is Enterococcus gallinarum. Of the following, the MOST effective antimicrobial agent for this infection is:AmpicillinCiprofloxacinLinezolidTicarcillinVancomycinCountdown10
84AAmpicillin is the most active B-lactam antimicrobial agent against most enterococcal isolatesEnteroccus SHOULD BE considered resistant to cephalosporins, aminoglycosides, ciprofloxacin and TMT/SMXE. gallinarum and Ecasseliflavus: vancomycin resistantLinezolid: can be used for vanco-resistant bacteria but few data in children
85Question 22 Among the following, the condition that is MOST likely to predispone a pediatric patient to the development of systemic candidiasis is?History of atopyHx of prematurityImmunosupressionPresence of indwelling urinary catheterRecent tonsillectomyCountdown10
86COf the opportunistic infections in children, candida is the most commonCandidiasis: blood + disseminated infectionCandidemia: blood + localized to central venous catheterRisk factors:Immunosupression: cellular (CHEMO PTS)Broad spectrum abxExtensive burnsLong term TPNPrematurity + comorbilities + poor nutritional status+ abxAlone NO RISK
87No RISK: Atopy Indwelling urinary catheter: bacterial Sx: exc if extensive and pt immunodepressed
88Question 23 A woman suffers a brief flu-like illness during he 34th wk of pregnancy and goes to labor. She delivers a 2.2kg baby who rapidly develops hypotension, respiratory distress and apnea. Finding include: fine, white nodules on the fetal surface of the placenta and thrombocytopenia. The most likely etiology of these findings is?C. botulinumE. coliGBSListeriaS. aureusCountdown10
89D Listeria: Gram + nonspore-forming rod Early: 1 wk: sepsis: shock, hypothermia, rsp distress, lethargy, apnea, metab acidosis, leukocytosis or neutropenia, thrombocytopenia)Late: 2wks: meningitis“flu-like illness” on mother 1-2 wks prior to delivery+ nodules in placenta (microabscess)Hx of miscarriages or stillbirths in motherIn severe cases baby develops microabscess in internal organs as well as on skinTx: ampicillin + gentamycin for 14 daysNO CEPHALOSPORINS: resistant
90GBSGram + diplococciNO active disease in mom, prolonged asymptomatic carriageRisk factors:PT <37wkprolonged ROM > 18hrsinfants born to women with high genital GBS inoculumintrapartum feverChorioamnionitisGBS bacteriuria during the current pregnancyprevious infant with invasive GBS disease.A low or an undectable maternal concentration of type-specific serum antibody to capsular polysaccharide of the infecting strain. =~ to listeria with acute and late onset (but this also includes: osteomyelitis, septic arthritis, cellullitis)SCREENING: wk (vaginal and rectal)Chemoprophylaxis: with Penicillin G 5 million U initially, then 2.5 to 3.0 million U, every 4 hours, until delivery
91Remember:If GBS status is unknown at onset of labor or ROM, give intrapartum prophylaxis to ALL women with gestation less than 37 weeks, duration of membrane rupture 18 hours or longer, or intrapartum temperature of 38.0°C (100.4°F) or greater+ GBS bacteriuria is enough for txNo prophylaxis in C/S
92Management of Neonates for Prevention of Early-Onset Group B Streptococcal (GBS) Disease. RED BOOK guidelinesa full workup: CBC, blood cx. CXR, LP –if septicdLimited evaluation includes: blood cx. CBCf If sepsis develop, do full workup + abxg If ≥37 weeks' gestation, observation may occur at home after 24 hours if other
93Question 24 A 2y/o F who has congenital hydrocephalus and a VPS has a T .102, irritability, vomiting for 3 days. She now has nucchal rigidity. Examination of CSF taken from the shunt reveals WBC 50, N: 65% and L 35% and a few Gram + cocci in clusters. The best abx to given this pt is?CefotaximeCefuroximeNafcillinPenicillinvancomycinCountdown10
94E Pt has a shunt-related ventriculitis Staphylococcus epidermidis (coagulase neg) or S. aureus (coagulase positive)VANCOMYCIN: bacteridal exc for enterococci
95Question 25 Physical exam of a 6wk old afebrile infant reveals a RR 74, and few crackles on inspiration. The 17y/o mother reports that the infant has had a loud cough but otherwise has been well except for some yellow eye drainage last week. The mother recently was treated for an “infection” in the genital area. Among the following, the MOST likely cause of the infant’s findings is?B0rdetella pertussisChlamydia trachomatisInfluenza type A virusRSVStreptococcus pneumoniaeCountdown10
96BInfants < 3months old with cough WITHOUT fever and a purulent eye discharge should be suspected of chlamydia trachomatis infection until proven otherwiseTachypnea, resp distress, crackles, NO wheezing“Staccato cough”50% purulent conjuntivitis50% otitisLAB: eosinophilia, increased serum IgsTX: Infants with chlamydial conjunctivitis or pneumoniaoral erythromycin base or ethylsuccinate for 14 days orazithromycin for 3 days
97Who to screen for chlamydia?- high risk Women with mucopurulent cervicitisSexually active women <20y/o> than 1 sexual partner in 3 monthsWomen who used barrier contraception inconsistently while in a nonmonogamous relationshipMen with dysuria + urethral d/c 7-14 days after contact
98Question 26 A 15 mo F who recently returned from visiting her grandmother in the Caribbean is found to have ascarisis. Of the following the best treatment is?IodoquinolMetronidazolPraziquantelPyrantel pamoatethiabendazoleCountdown10
99D 1 dose of pyrantel pamoate Iodoquinol: entamoeba histolytica Also willl work: mebendazole x 3d OR albendazole 1 dose but NOT studied in kids < 2y/oIodoquinol: entamoeba histolyticaMetronidazole: Giardia lambdia, E. hystolytica, trichomocnas vaginalisPraziquantel: schistosoma, tapewormThiabendazole: strongyloides, cutaneous larva migrans
100Question 27 A 9 mo boy was exposed 5 days ago to a child who has confirmed rubeola. Among the following, the intervention that is MOST likely to prevent measles in the exposed child is administration of?AcyclovirIM immunoglobulinIV immnunoglobulinMMR vaccineMMR vaccine + IM immunoglobulinCountdown10
101BThe risks for complications as a result from measles is high among infants <1y/oImmunoglobulin given within 6 days of exposure can prevent or modify the disease.Prefer IM (0.25ml/kg)IV: has same concentration, but higher costIn an outbreak situation or if the exposure to measles occurred within the previous 72hrs, administer MMR vaccine to infants as young as 6mo old.
102Question 29 During an emergent evaluation of a 7y/o girl with slurred speech, ataxia and gralized hypotonia, you note brief rapid, jerking movements of the limbs and face. She is alert and oriented. Examination of the cranial nerves is normal. Deep tendon reflexes are 2+ and symmetrical in the upper and lower extremities. Which of the following cutaneous findings is most likely to be identified in pts with similar signs and symptoms?A blotchy, gralized erythematous, blanching macular rashErythematous, nontender, circumscribed patches over the cheeks, sparing the perioral regionSeveral patches of grouped thick-walled vesicles on an erythematous base, some of which have become ulcerated in appearanceGeneralized desquamation of the skin characterized by large, thin flakes, especially prominent in the groin and axillaA gralized purpuric and petechial rashCountdown10
103DGirl with sudden onset of chorea + hypotonia + speech difficulty= sydenham choreaUncontrollable, with complete inability to ambulateSudden decrease in school performance (dramatic change in handwritting)facial grimmacingthrusting tongue movementsUncharacteristic irritability, emotional labilityCan present inmmediately after strep infections or months laterSkin characteristics (desquamation in groin and axilla) follows 5-7 days after sandpaper rash
105A 15y/o F with turner syndrome and a hx of bicuspid valves presents with fever, extreme fatigue, anorexia and malaise. Her Temp On PE, a previously noted systolic ejection click is associated with a new harsh ejection murmur. Additional clinical findings include mucous membrane and extremity petechiae and blanching painless erythematous lesions on the palms and soles.Which of the following is the most likely cause of this pt’s clinical signs and symptoms?Question 30 A 15y/o F with turner syndrome and a hx of bicuspid valves presents with fever, extreme fatigue, anorexia and malaise. Her Temp On PE, a previously noted systolic ejection click is associated with a new harsh ejection murmur. Additional clinical findings include mucous membrane and extremity petechiae and blanching painless erythematous lesions on the palms and soles. Which of the following is the most likely cause of this pt’s clinical signs and symptoms?S. pneumoniaeViridans streptococciE. coli O157:H7Neisseria meningitidesH. influenzae type bCountdown10
106B Subacute bacterial endocarditis S. aureus >> s. viridans>> coagulase neg staph>> GBS and GASIf suspicion: f/u blood cx for 7 days (fastidious bacteria or fungi)At least 3 blood cx> of SBE in children >2y/o have a preexisting structural cardiac abnormality (bicuspid aortic valves, septal defects, coarctation of aorta, TOF, a prosthetic valve) and present with new or worsening murmur.
107Skin manifestationsOsler nodes: painful nodules on the pulp of finger or toesRoth spots: edematous hemorragic lesions within retinaJaneway lesions: red macular blanching palmsand soles-painlessSplinter hemorrhages:non blanching, linear red-brownbeneath nail beds
108Question 31 A 6y/o girl presents with the sudden onset of brief, purposeless movements of her arms and legs associated with generalized hypotonia and irritability. Results of laboratory evaluation include include a markedly elevated ASO (antistreptolysin) level. Which of the following is most likely to be identified in this patient?Repetitive hand wringing and sighing respirationsInvoluntary apposition of the thumb and visible contraction of the muscles of the thenar eminence upon percussion of the thenar eminence with a reflex hammerIntermittent episodes of painful blanching, followed by cyanosis and then hyper-erythema of the fingers and toesDelayed relaxation of the fingers when asked to grip the examiner’s fingers and release rapidlyRepetitive relaxation and tightening of the hand when asked to shake hands with the examinerCountdown10
109E Recent GAS Sydenham chorea: “milkmaid’s grip” “spooning” Relaxation and tightening handshake“spooning”“darting tongue’Inability to protrude the tongue for more than a few seconds“pronator sign”Outward movement of the arms and palms when held above the head
110Hand wringing and sighing respirations: RettInvoluntary apposition of thumb+contraction thenar eminence muscles upon percussion with hummer +delayed relaxation:myotonic dystrophyIntermittent episodes of blanchingcyanosishyperemia:Raynaud phenomena
111Question 32 A 4y/o boy presents with a 1 wk hx of painful bowel movements that have caused him to attempt to withhold his stool and refrain from using the bathroom. He complains of persistent perirectal pain and mild associated pruritus. On PE, a flat, well demarcated, tender, intensely erythematous and moist perianal eruption, associated with a perianal fissure is noted. Which of the following is the most appropriate next step in the treatment of this patient?Oral penicillinOral polyethylene glycolTopical nystatin powderTopical acyclovir creamTopical corticosteroid creamCountdown10
112A Perianal streptoccal dermatitis Associated constipation Voluntary whitholdingPeaks at 4-5y/o> in boysAssociated with symptomatic or asymptomatic GAS colonization in the throatUnexpected flare of psoriasisTx: oral penicillin