Presentation on theme: "Matt Padd Genetics. How does it occur? Triple x occurs when there is a third X chromosome present with two other sex chromosomes in a female. Therefore,"— Presentation transcript:
Matt Padd Genetics
How does it occur? Triple x occurs when there is a third X chromosome present with two other sex chromosomes in a female. Therefore, three X’s are present. Normal set’s of chromosomes have only two sex chromosomes, however there is an extra X making the cell aneuploid. Nothing definitely is known about the causes of the chromosomes irregularity, which leads to non- disjunction as the primary cause of the third X.
History The first published report of a woman with a 47,XXX karyotype was by Patricia A. Jacobs, in Edinburgh, Scotland in She was a 35-year-old, 5 ft. 9 in., 128 lb. woman who had premature ovarian failure at age 19; her mother was age 41 and her father was 40 at the time of her conception. Occurs more often when older men and women conceive vs. younger couples.
Inheritance Triple X syndrome can not be inherited. It is an error in cell division during early embryonic development. It has nothing to do with your past. Triple X occurs in 1 out of every 1000 females at birth. Five to ten girls are born in the U.S. every day with Triple X.
Type of mutation Triple X is a chromosomal mutation.
Effects Learning disabilities. 1. Delayed motor and linguistic development as well as a delayed emotional maturing. 2. Poor socialization skills. 3. Increased stress Taller then average development. History of early back problems. Small head
Diagnosis Triple X is diagnosed prenatally through a CVS(chorionic villus sampling) or Amniocentesis. It can also be diagnosed through a blood text after a baby’s birth. All these test’s work by looking at the karyotype and making the conclusion upon that viewing.
Treatments Triple X is an irreversible disorder with no cure. However Triple X is possible to treat. Treatments depends on the symptoms of the carrier. Counseling such as psychological counseling is really the only treatment to mild the effects of triple X syndrome.
46,XX/47,XXX mosaicism Three sex chromosomes are only present in some cells vs. triple X where three sex cells are present in all cells. Females with Mosaicism usually have fewer effects as they have less cells with three X chromosomes.
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