Presentation on theme: "PolExGene meeting February, 8-9 2007 Paris, ENS CNRS Montpellier (France) Max Mousseron Institute of Biomolecules Pr. Jean Martinez, Dr. Muriel Amblard."— Presentation transcript:
PolExGene meeting February, 8-9 2007 Paris, ENS CNRS Montpellier (France) Max Mousseron Institute of Biomolecules Pr. Jean Martinez, Dr. Muriel Amblard Dr. Gilles Subra WP 2 : Synthesis of Selected CPP WP 3 : Synthesis of Selected CIP
N-hydroxysuccinimide peptide (covalent link) Protected-(RQIKIWFQNRRMKWKK)-NHS Protected-(GRKKRRQRRRPPQ)-NHS Protected-RRRRRRRR-NHS Nter Cys peptides for maleimide ligation or SS bond H- or Ac-Cys-RQIKIWFQNRRMKWKK-OH H- or Ac-Cys -GRKKRRQRRRPPQ-OH H- or Ac-Cys -RRRRRRRR-OH Cell Penetrating Peptide for covalent anchoring on cationic polymers (proposition) Cter Cys peptides for maleimide ligation or SS bond H- or Ac- RQIKIWFQNRRMKWKK- Cys -OH H- or Ac- GRKKRRQRRRPPQ- Cys -OH H- or Ac- RRRRRRRR- Cys -OH Rem: Cys can be repaced by simpler thiol containg group
Other Perspectives Penetratin, Tat or polyarginine beta-peptides Peptoids Bioavailability Modified CPP Selection of CIP Specific sequences for specific receptors: RGD? Other specific ligands? ‘Tagged’ CPP N-ter, C-ter or within chain (FTIC, others?, Qdot?)
Needs of PolExGene Partners CPP and CIP Type (tat, Arg, penetratin, others?) Quantity? Purity? Number of analogues (only one?) Fonctionnalisation? Protection?
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