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Agenda I.Overview of U.S.– EU Cooperative Efforts (Philip Sayre, EPA) II.Description of Communities of Research (Sally Tinkle, NNCO) III.Discussion with.

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Presentation on theme: "Agenda I.Overview of U.S.– EU Cooperative Efforts (Philip Sayre, EPA) II.Description of Communities of Research (Sally Tinkle, NNCO) III.Discussion with."— Presentation transcript:

1 Agenda I.Overview of U.S.– EU Cooperative Efforts (Philip Sayre, EPA) II.Description of Communities of Research (Sally Tinkle, NNCO) III.Discussion with COR co-chairs (Kai Savolainen, TTL) A.Exposure through the Life Cycle, with Material Characterization (Richard Canady, ILSI Research Foundation and Flemming Cassee, National Institute for Public Health and the Environment) B.Ecotoxicity Testing and Predictive Models, with Material Characterization (Henriette Selck, Roskilde University) C.Predictive Modeling for Human Health, with Material Characterization (Bengt Fadeel, Karolinska Institutet and Nathan Baker, PNNL) D. Open Discussion on Three CORs IV.Future Collaborations A. Two to three Video Conferences for each COR between late April and October hosted by NNCO and the EU (Sally Tinkle, NNCO) B. Launch of Additional CORs: May, Grenoble, NSC meeting (Kai Savolainen, TTL) C. The 2012 U.S. - EU Workshop: October, Helsinki (Kai Savolainen, TTL) D. Workshop Proceedings and Next Steps: (Sally Tinkle, NNCO)www.us-eu.org

2 Overview of U.S. – EU Cooperative Efforts Philip Sayre, EPA

3 Purpose of U.S. – E.U. Partnering Engage researchers, regulators, and granting entities in an active discussion on EHS research needs Identify research that would benefit from joint efforts Establish Communities of Research (CORs): themes, key contacts, and and other collaborative mechanisms Existing Research Coordination and Programs in the U.S, the E.U., and beyond E.U.-- FP7 – Seventh Framework Programme - Industrial Technologies for research projects in Nanotechnologies, materials and production technologies (NMP) - NanoSafety Cluster (NSC): a cooperation platform for EU and National research projects - U.S Federal Partners; research coordination through OSTP: NNI’s Nanotechnology Environmental, Health and Safety Implications Working Group EHS Strategic Research Plan – Individual Agency & Department websites Additional International Organizations (ISO, OECD, others)

4 10-11 March 2011 Workshop Stakeholder Perspectives: E.U., U.S., International Bodies, Industry, and NGOs Data Needs for Regulatory Decision-making Human Health Environment Producing Reliable and Reproducible Data for Assessment and Management When do unique properties, with risk assessment implications, arise? How do surface modifications and chemical transformations affect toxicity? Dose metrics, and how are dose-response data best extended to OELs / environmental concern concentrations? How relevant are model nanoparticles to understanding exposures in the workplace? What are the critical parameters and data needs for understanding the behavior of nanoparticles in the environment? What are the critical parameters and data needs for understanding the behavior of nanoparticles in consumer and general population exposures? Industrial risk management considerations for worker protection Collaborative Mechanisms for Joint Work

5 Areas of Interest, Based on 2011 Workshop Over 200 Attendees, from Numerous Stakeholder Groups, Identified Similar Needs Selected Workshop Findings Ecological Effects and Fate Source characterization (inventories, actual sources, and rates of release) Grouping of nanomaterials into classes that imply fate and effects outcomes Deeper understandings of bioavailability, transformation, and receptor susceptibility Health Effects Reference nanomaterials, including positive and negative controls Harmonized testing protocols, and consideration of realistic exposure scenarios Cross-cutting Needs for Health and Ecological Effects, and Environmental Fate Identification of unique properties: intrinsic and contextual Sets of nanoparticles with systematic variations; improved detection techniques Informatics to gather both positive and negative results for trends’ discoveries Surface modification effects on particle interactions with biological and environmental media Assessing Risks in the Workplace Exposure assessments limited in terms of types of nanomaterials and scenarios Model nanoparticles : representative, well characterized, use in measurement and modeling

6 Description of Communities of Research Sally Tinkle, NNCO

7 Communities of Research for Nanotechnology EHS

8 The Model: Communities of Practice formed by groups of people share a significant interest in a topic and interact regularly to advance that interest, develop a shared repertoire of resources: experiences, tools, ways of addressing recurring problems—in short a shared practice do not necessarily work together on a daily basis.

9 Communities of Research for NanoEHS (CORs) groups of people: US-EU scientists share a significant interest: nanoEHS develop a shared repertoire of resources: experiences, tools, ways of addressing recurring questions and challenges regular contact: use wikis, webcasts, conference calls, annual US-EU meeting.

10 CORs for NanoEHS Launch today With materials characterization in all three: Exposure through the Life Cycle Ecotoxicity Testing and Predictive Models Predictive Modeling for Human Health Launch at Nanosafety Cluster meeting in Grenoble (June) Databases and ontologies Risk assessment Risk management and control measures

11 Discussion with COR co-chairs Moderator: Kai Savolainen, TTL  5 minutes for each presentation  5 minutes for Q & A after each presentation

12 Agenda for Today, and Next Steps I.Overview of U.S.–E.U. Cooperative Efforts (Phil Sayre) II.Description of Communities of Research (Sally Tinkle) III.Discussion with COR co-chairs 1.Exposure through the Life Cycle, with Material Characterization: (Richard Canady/US and Flemming Cassee/EU) 2. Ecotoxicity Testing and Extrapolation towards QSARs, with Material Characterization: (Steve Klaine/US and Henriette Selck/EU) 3. Predictive Modeling for Health, with Material Characterization: (Nathan Baker/US and Bengt Fadeel/EU)

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15 Predictive Modeling for Human Health, with Material Characterization Bengt Fadeel, Karolinska Institutet Nathan Baker, Pacific Northwest National Laboratory

16 Predictive Modeling for Health, with Material Characterization EU chair: Bengt Fadeel, Karolinska Institutet; US chair: Nathan Baker, Pacific Northwest National Laboratory Topics covered: Nanomaterial characterization (“synthetic identity”) Nanomaterial ontology and informatics High-throughput screening (HTS) approaches to nanomaterial testing In silico modeling eg. QSAR (structure- activity) and PBPK approaches to predict nanomaterial fate and behavior (“biological identity”) Molecular simulation of bio-nano- interactions, and other modeling approaches

17 Toward toxicity testing of nanomaterials in the 21 st century: a paradigm for moving forward Lai D. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology Jan-Feb;4(1):1-15.

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19 NanoParticle Ontology: an example view Thomas DG, Pappu RV, Baker NA. NanoParticle Ontology for Cancer Nanotechnology Research. J Biomed Inform [in press]

20 Damoiseaux et al. No time to lose--high throughput screening to assess nanomaterial safety. Nanoscale. 2011;3(4): No time to lose--high throughput screening to assess nanomaterial safety. Shaw et al. Perturbational profiling of nanomaterial biologic activity. Proc. Natl. Acad. Sci. U.S.A. 2008;105: Perturbational profiling of nanomaterial biologic activity. High content/high-throughput screening

21 ACS Nano.ACS Nano Oct 26;4(10): Quantitative nanostructure-activity relationship modeling. Fourches DFourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ, Tropsha A.Pu DTassa CWeissleder RShaw SYMumper RJTropsha A

22 COST workshop on Quantitative Nanostructure-Toxicity Relationships (QNTR) April 2011 The aim of the workshop was to bring together leaders in the emerging field of computational nanotoxicology to form an international Community of Practice for accelerated development of the science of QNTR Copies of all the presentations at the workshop can be found at: A proposal for a COST action (network) has been submitted; coordinator: Dr. Lang Tran, Edinburgh

23 Physiologically-based pharmacokinetic modeling Riviere JE. Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots. Wiley Interdiscip Rev Nanomed Nanobiotechnol Jan- Feb;1(1):26-34.Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots. Li M, et al. Physiologically based pharmacokinetic modeling of nanoparticles. ACS Nano Nov 23;4(11): Physiologically based pharmacokinetic modeling of nanoparticles. Stages involved in absorption, distribution, metabolism and elimination (ADME).

24 Kagan et al., Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat. Nanotech May;5(5):354-9.Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Shi et al. Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. Nat Nanotech Sep 18;6(11):714-9.Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. Molecular modeling/simulation

25 Getting it done together: towards US-EU cooperation on modeling of nanomaterial behavior in biological systems

26 Open Discussion on Three CORs (15 minutes)

27 Agenda for Today, and Next Steps IV Future Collaborations (Sally Tinkle and Kai Savolainen) – A. Two to three Video Conferences for each COR – B. Launch of Additional CORs – C. The 2012 U.S. – E.U. Workshop – D. Workshop Proceedings, and Next Steps

28 Two to three Video Conferences for each COR between late April and October hosted by NNCO Sally Tinkle, NNCO

29 Launch of Additional CORs: May, Grenoble, NSC meeting Prof. Kai Savolainen, TTL

30 Next NanoSafety Cluster meeting to be held in Grenoble, France on Thursday, May 31, 2012 (during SIIN ERA-Net Meeting, May 29-31) Agenda for the NanoSafety Cluster Meeting, May 31: 9-12Strategic Research Agenda for NanoSafety : – Now 14 thematic WG preparing justification of research priorities to be chosen, Editorial Group responsible for strategic perspective – In the strategy document strategy issues under vision, introduction plus justification and elements of the strategy, cross-cutting issues, recommendations and conclusions on research priorities, will be dealt with – As a part of integration, the 14 WG create 4 larger overarching themes: 1) material identity; 2) transformation & exposure; 3) hazard mechanisms; and 4) risk prediction tools Future Collaborations

31 Agenda for the NanoSafety Cluster meeting in Grenoble on May 31, Launch of 3 Additional CoRs and request expression of interests for their chairs and members: » Database + Ontology » Risk Assessment » Risk Management and Control The goal is to lauch the three remaining CoR's in Grenoble and to have the US colleagues to attend discussions in Grenoble on-site if possible

32 The 2012 U.S. – EU Workshop: October, Helsinki – the workshop will follow-up and further elaborate the discussions that begun at the "U.S.-EU bridging nanoEHS research - A Joint Workshop" held on March 2011 in Washington – currently drafting the program with parallel sessions for CORs; feedback from NNCO and EC on the proposed agenda (program, for EC Kai Savolainen and Kenneth Dawson) – room for 120 persons (including invited speakers and guests)

33 Workshop Proceedings and Next Steps: Sally Tinkle, NNCO

34 A. Two to three Video Conferences for each COR between late April and October hosted by NNCO and EU 1. Please COR co-chairs if interested in one of Existing CORs or use the sign-up sheets in the back of the room 2. Please one of the U.S. or EU Contacts to get on the mailing list or express interest in a new COR topic: a. NNCO Contact Diana Petreski: b. EU Contact Nicolas Segebarth: B. Discussion on Additional CORs: 31 May, Grenoble, SIINN-NSC meeting C. The 2012 U.S. – EU Workshop: October, Helsinki D. Workshop Proceedings and Next Steps:  Questions and Answers Future Collaborations


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