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How the Brain Works 1
Background: The Synapse 2
Release Signal 3
Receptor binding 4
Receptors: Excitatory: Sends signals (action potentials) Inhibitory: Blocks signals Drugs, neurotransmitters, and other ligands: Agonists: Stimulate receptors, mimic the neurotransmitter Antagonists: Block receptors 5
Agonists and Antagonists NeurotransmitterAgonist (drug)Antagonist (drug) 6
Little quiz What would each of the following do?: Excitatory receptor Inhibitory receptor Agonist Antagonist 7
Little quiz What would each of the following do?: Excitatory receptor Inhibitory receptor Agonist+++ More signal --- Less signal Antagonist--- Less signal +++ More signal 8
Example drugs What would each of the following do?: Excitatory receptor Inhibitory receptor Agonist+++ Nicotine --- Alcohol Antagonist--- Benadryl, Dimetapp +++ Caffeine 9
Glutamate The most common excitatory neurotransmitter Glutamate is releasd by 80% of neurons Learning Memory 10
GABA The most common inhibitory neurotransmitter in the brain Sleep Muscle relaxation Anxiety relief Impairs memory 11
How drugs mimic neurotransmitters: Drugs look like chemicals normally found in your body 12
Norepinephrine Fight or Flight Increases heart rate Excitement Fear 13
Epinephrine and phenylephrine 14
Dopamine The Salience Neurotransmitter Rewards sex, eating Increases alertness, happiness 15
Addiction Do cocaine Do more cocaine Damage decision-making and reward-seeking parts of brain 16
Serotonin (5-HT) The Satiety Neurotransmitter Feelings of fullness, contentment Relieves depression 17
Serotonergic drugs I 18
Serotonergic drugs II 19
Cannabinoids Marijuana mimics these molecules in the brain 20
Opioids Morphine mimics these Relieve pain and worry Induce sleep Slow digestive tract 21
Acetylcholine (ACh) Nicotine mimics this Alertness Memory Moves muscles Causes secretions (saliva, sweat) 22
Dopaminergic and cholinergic drugs 23
Histamine Alertness Itchiness Rashes Causes stomach acid secretion 24
Other small neurotransmitters 25
Adenosine and caffeine 26
Drugs and the Brain Teaser Zak Fallows
25 seconds left….. 24 seconds left….. 23 seconds left…..
OPTION E E4 NEUROTRANSMITTERS AND SYNAPSES. Pre-synaptic neurons can either excite or inhibit post-synaptic transmissions. (AP = “______________”) This.
Neurotransmitters Are Your Friends. Some Basics on Neurotransmission Neurotransmitters either excite or inhibit other neurons – Agonists bind to receptor.
Jeopardy Q 1 Q 6 Q 11 Q 16 Q 21 Q 2 Q 7 Q 12 Q 17 Q 22 Q 3 Q 8 Q 13
Upload “Neurotransmitters and Drugs” To eBackpack.
The Nervous System-Part II Neurotransmitters, Drugs and Disease of the Brain.
The Nervous System-Part II Neurotransmitters. Action Potentials Target Neurotransmitter Release.
Drugs and the Nervous System. Classes of Drugs 1. Depressants 2. Stimulants 3. Hallucinogens.
Widely Found and Studied Neurotransmitters Glutamate – has excitatory functions 4 Ascending activating systems are very important Cholinergic System.
We are here Central Nervous System Brain Brain Imaging Peripheral Nervous System Building Blocks Genetics Evolutionary Endocrine System Neurotransmitters.
We will resume in: 25 Minutes We will resume in: 24 Minutes.
© Cengage Learning 2016 Psychopharmacology Chapter Four.
Chapter Four Psychopharmacology Version Dated 21 Sep 2009.
E4 Neurotransmitters and synapses Ms. TRS. E.4.1 State that some presynaptic neurons excite postsynaptic transmission and others inhibit postsynaptic.
Pharmacology of central Neurotransmitters Prof. Yieldez.
What is a neurotransmitter? Chemicals secreted by neurons Stimulated action potential in adjacent neurons Two types of responses: Excitatory Inhibitory.
Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.
ABC Technology Project Mrs. Kiddle. ABCs of Technology Word 1 Word 2 Word 3 Word 4 Word 5 Word 6 Word 7 Word 8 Word 9 Word 19 Word 20 Word 21 Word 22.
Neurotransmissions in the Central Nervous System Prof. Alhaider.
chemicals released by vesicles in sending neuron travel across the synapse and bind to receptor sites on receiving neuron 2 TYPES = EXCITATORY = stimulate.
WEEK 1 You have 10 seconds to name…
Addition 1’s to
OPTION E E4 NEUROTRANSMITTERS AND SYNAPSES. Pre-synaptic neurons can either excite or inhibit post-synaptic transmissions. (AP = “all-or-nothing”) This.
Neurotransmissions in the Central Nervous System.
Chapter 3 pt. A: Biology, Neurons, and Brain Imagery.
Synaptic Transmission Chapter 4 Pages Chemical Synapses Most synapses in the brain are chemical. Electronically coupled gap junction synapses.
E.4 Neurotransmitters and Synapses. E4.1 Postsynaptic Responses Pre-synaptic neurons can inhibit or excite the post synaptic neuron by releasing excitatory.
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Neurons & the Nervous System Chapter 2: The Brain and Behavior.
© 2013 Pearson Education, Inc. Chapter 18, Section 6 4/13/2013 Chemical Messengers Neurotransmitters Hormones Supplemental.
Neurotransmitters Many Neurotransmitters (NT) exist: -Dopamine -Adrenaline -Serotonin -Acetylcholine Drugs can either: –Increase the effect of certain.
Neurotransmitters Information in this presentation taken from UCCP Content.
GG Consulting, LLC I-SUITE. Source: TEA SHARS Frequently asked questions 2.
Neurons, Neurotransmitters, and Systems. Structure of a Neuron.
The Nervous & Immune System Bio and the Body 2014 Ms. Boehm.
Drugs and the Brain Zak Fallows ESP Splash (Saturday) These slides are available online, along with fun 5-minute quizzes.
DIVIDING INTEGERS 1. IF THE SIGNS ARE THE SAME THE ANSWER IS POSITIVE 2. IF THE SIGNS ARE DIFFERENT THE ANSWER IS NEGATIVE.
Option E.4. Assessment Statements E.4.1 State that some presynaptic neurons excite postsynaptic transmission and others inhibit postsynaptic transmission.
Neurotransmitters & Receptors. Sensory neuron Motor neuron Receptor potentialAction potential Synaptic potential Action potential.
The Biological Bases of Behavior: The Neuron What is the nervous system?
Chapter 5 Test Review Sections 5-1 through 5-4. Simplify each expression. 1)2) 3)4) 5) 6)
E.4 Neurotransmitters and Synapses. E.4.1. Some Pre-synaptic neurons excite postsynaptic transmission and others inhibit postsynaptic transmission.
1 11 How is the Nervous System Organized? Chapter 3-Neuroscience: The Brain and Behavior.
© 2012 National Heart Foundation of Australia. Slide 2.
Catalyst #17 Pg. 87- Take out Flashcards 1.Go to the class website Open and do the Catalyst: Anatomy: Lesson 85- Catalyst #17-4/3-4/4 AND ANATOMY: LESSON.
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