Presentation on theme: "1 The American Parkinson Disease Association (APDA) * allowed this statement in its newsletter #21 in 2006: “Parkinson’s disease remains a condition which."— Presentation transcript:
1 The American Parkinson Disease Association (APDA) * allowed this statement in its newsletter #21 in 2006: “Parkinson’s disease remains a condition which cannot be prevented or cured”. Perhaps they cannot read graphs? * APDA, 135 Parkinson Av., Staten Island, N.Y. 10305 1 800 223 2732 But what about the data since 1990s? If a cause is known, that is the beginning of prevention. Rejoice APDA! Don’t deny! Fund RCTs (Randomised Controlled trials) Why has almost nothing been done to reduce the incidence of PD? Why do so many of those suffering have no idea what might have caused it? File name: PD 11 Actions
2 What causes PD? “As is the case with many neurological disorders, the cause of Parkinson’s disease is not known. However, scientists and researchers are working diligently to uncover the possible cause(s), including genetics and environmental factors, of Parkinson’s disease.” FROM PARKINSON DISEASE FOUNDATION * WEB 2007 * Parkinson’s Disease Foundation 1359 Broadway, Suite 1509 New York, NY 10018 (212) 923-4700 (800) 457-6676 Fax (212) 923-4778 email@example.com www.pdf.org “2007”!!! Slow learners? Like the APDA.
3 In the UK: May 30 th 2007 Gardeners ‘more likely to develop Parkinson’s disease’ Dr. Finlay Dick, University of Aberdeen “Further research is needed to establish which pesticides are associated with this effect” “The exposure-response relationship suggests that pesticide exposure may be a causative and potentially modifiable risk factor” YES!
4 However, there is hope: In APRIL 2007 the Michael J. Fox foundation noted, quite correctly “The Parkinson’s Disease Biomarker - - - the UPDRS - - - is a clinical measure…”very sensitive to symptom-masking effects of drugs, which can make it very difficult to measure underlying disease modifying effects sought in neuroprotective trials.” Comment: Correct! AND there do not seem to be any quantitative measures of accuracy, eg inter-rater reliability or predictive validity. (An objective measure developed at UCLA should receive further funding.) “…one of the greatest hurdles in developing new treatments..is the lack of good measurements”..
5 Results Exposure to pesticides was reported by 7,864 participants (5.7%), including 1,956 farmers, ranchers, or fishermen. Individuals exposed to pesticides had a 70% higher incidence of PD than those not exposed (adjusted relative risk, 1.7; 95% confidence interval, 1.2-2.3; p = 0.002). The relative risk for pesticide exposure was similar in farmers and nonfarmers. No relation was found between risk for PD and exposure to asbestos, chemical/acids/solvents, coal or stone dust, or eight other occupational exposures. These data support the hypothesis that exposure to pesticides may increase risk for PD. Future studies should seek to identify the specific chemicals responsible for this association. Annals of Neurology 2006 MORE HOPE: Funded by:Michael J. Fox Foundation, & Kinetic Foundation & National Institute of Environmental Health Sciences; Grant Number: ES10804. Research by Alberto Ascherio (firstname.lastname@example.org)email@example.com <--- before the denials of APDA and PDF !!!
6 June 26 th 2006 Researchers at the HARVARD SCHOOL OF PUBLIC HEALTH undertook a prospective study to examine possible links between chronic low-dose exposure to pesticides and PARKINSON’s disease. Further information from firstname.lastname@example.org “The significant association between pesticide exposure and Parkinson’s disease among individuals who are not farmers is most likely explained by use of pesticides at home or in gardening
7 Gardening is dangerous! So are sprays. Does someone spray your condo or house with pesticides you’ve never heard of ? ASK! You might eventually suffer from Tremors Stooping stance Deformed jaw Loss of balance Stuffy nose and loss of sense of smell A wandering eye Rigidity Memory loss Etc…… Ask your garden center to stop using pesticides Then, eventually, a lack of responsiveness: a blank stare, needing 1-on-1 care - - - a living death. Then finally an early death from Parkinson’s
8 So.. It is clear that pesticides are a major cause of PD M any studies, carefully meta analysed + feasible mechanisms : eg insect neurons destroyed by the same pesticide-damage that kills human neurons or rat neurons Yet, in the US, very few people know that pesticides are a major cause and, it seems, there is no good system to ban those pesticides that should be banned.... and insufficient warnings to gardeners and agricultural workers. HOW MANY PEOPLE WILL SUFFER PARKINSON’S BEFORE THE POWERS-THAT-BE BEHAVE ETHICALLY and intelligently ? BUT..the APDA is still in denial about pesticides: a leaflet for its 2008 ‘Walk-a-thon’ states “the ultimate goals of discovering the cause and cure remain elusive”. Causes are known….A cure is not! Don’t they read?!
9 Pesticides Pharmaceutical companies benefit from both ? Parkinson’s medications for 1.5 million people in the US cause Make moneyMake money
10 Found on the web: Chance confirmation of tentative suspicions that companies benefit from both Pesticides AND Parkinson’s. “With revenues of $14 billion, Zeneca is among the world's largest manufacturers of pesticides, plastics, and pharmaceuticals.” Comments welcome at: email@example.com. End the tragedy of Parkinson's - - - BAN PESTICIDES (Hire more gardeners and farm workers - - - and provide better working conditions)
11 Please…….. ___ Send information to your members of Parliament in the UK or your representatives in the US House and Senate. Urge that pesticides be banned until good research picks out which, if any, can be used safely. ___Show your Doctor… Does he or she know what is the likely cause of the ever-increasing numbers of tortured People-with-Parkinson’s? ____Warn gardeners and farm-workers ____Initiate a law suit….??