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2014 年 4 月研究生读书报告 王凯 硕士研究生 临床检验诊断学. Seminars In Cancer Biology A review of the current understanding and clinical utility of miRNAs in esophageal cancer.

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Presentation on theme: "2014 年 4 月研究生读书报告 王凯 硕士研究生 临床检验诊断学. Seminars In Cancer Biology A review of the current understanding and clinical utility of miRNAs in esophageal cancer."— Presentation transcript:

1 2014 年 4 月研究生读书报告 王凯 硕士研究生 临床检验诊断学

2 Seminars In Cancer Biology A review of the current understanding and clinical utility of miRNAs in esophageal cancer Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma Cancer Discovery

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4 Four miRNAs (mi-R-25, -99a, -133a and - 133b) showed good potential as diagnostic markers and interestingly five (mi-R-21, -27b, -126, and -145) appeared to be useful both as diagnostic and prognostic/predictive markers.

5 Summary of studies looking at miRNA expression in tumor tissues and non-tumor tissues

6 Summary of miRNAs identified to have a role in determining prognosis

7 Summary of key miRNAs identified as having a potential role in the diagnosis and/or prognosis of oesophageal cancer

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9 11 EAC 23 fresh- frozen primary tumors NOTCH1 TP53 C:G>G:CA:T>C:G Tumor Tissue EAC 12 ESCC

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11 Find out the drive gene MicroRNAs matched with the drive gene Quantitative detection of the expression of the gene and microRNA Analyze the relationship between the expression of the gene and microRNAs Experimental verification

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