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Wang TINS 2001 Wang Neuron 2002 An integrated microcircuit model of working memory and decision making
Lorente de Nó’s reverberatory circuit
Roitman and Shadlen 2002
Reaction Time Task
2-population excitatory and inhibitory neurons (integrate-and-fire or conductance-based Hodgkin-Huxley neurons) Biologically realistic synaptic kinetics (AMPA, NMDA and GABA A ) Structured network connectivity
Reaction Time Simulations
Data by J Roitman, J Ditterich and M Shadlen Reaction time decreases with increasing coherence Weber's Law
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c’=6.4% c’=51.2% c’=100%
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A Large-scale Network Model of Decision-Making Cortex Caudate SNr SC
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Threshold can be effectively modulated by the cortico-striatal synaptic pathway
Adjusting the threshold to optimize rewards: Speed-accuracy tradeoff
Optimal threshold should be adjustable according to the distribution of coherence levels in the environment
Xiao-Jing Wang Department of Neurobiology Yale University School of Medicine The Concept of a Decision Threshold in Sensory-Motor Processes.
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Visual Attention Attention is the ability to select objects of interest from the surrounding environment A reliable measure of attention is eye movement.
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A neural mechanism of response bias Johan Lauwereyns Laboratory of Sensorimotor Research National Eye Institute, NIH.
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