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Inflammatory Bowel Disease

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Presentation on theme: "Inflammatory Bowel Disease"— Presentation transcript:

1 Inflammatory Bowel Disease
MR Enterography Inflammatory Bowel Disease

2 Why? What the clinician wants to know
Presence, localization, and extent of disease Complications – strictures, abscesses, fistulas Disease activity – active vs fibrotic

3 How to do it? Patient prep Oral contrast
Bowel prep day before – low residue diet, fluids, laxative Overnight fasting or NPO 4-6 hrs prior to study Oral contrast Water results in inadequate distention, long transit time Biphasic oral contrast agents Different signal intensities on different sequences (low T1, bright T2) VoLumen - a low-conc barium (0.1% weight/volume) that contains sorbitol (CHOP, Emory 2007) Mannitol, sorbitol and polyethylene glycol have been used to slow down intestinal reabsorption of water Can cause N/V, diarrhea, cramping

4 How to do it? Prone positioning Glucagon IM or IV Timing –
to stop peristalsis ½ dose before study starts, ½ dose prior to contrast Timing – Typical adult L over min Child 1 L one hour prior to exam Filling of TI occurs in kids at minutes, adults 1 hour Rectal contrast – water enema for better distention of colon, TI not generally used unless incomplete colonoscopy MR Entercolysis – improved bowel distention (esp jejunum) Invasive, time consuming

5 Egleston Protocol No patient prep
Oral contrast – Kool-aide with gastroview Powerade/gatorade cannot be used due to susceptibility artifact Timing 2 doses – first dose wait one hour, then drink ½ scan 30 minutes later Ex : 24/12 Volume and timing same as CT guidelines No glucagon Supine position Magnevist

6 Sequences T2w HASTE (haste, spair) TrueFISP (trufi, space)
Post contrast Axial and coronal planes Coronal plane good for terminal ileum, appy; good overview Sagittal thru pelvis

7 HASTE haste – non FS spair - FS Fast
High contrast between bowel lumen and wall Best sequence for determining bowel wall thickness Fluid collections Submucosal edema (spair) Sensitive to intraluminal flow voids Poor evaluation of mesentery

8 TrueFISP trufi space - pelvis Fast Relatively motion insensitive
High contrast between small bowel lumen and bowel walls Homogeneous endoluminal opacification Good mesenteric anatomy (LAN, comb sign, vessels) Susceptibility artifacts from intraluminal air Chemical shift artifacts – black boundary Occurs in pixels with fat & water Improved with FS

9 Post contrast VIBE & FLASH
Venous, delayed for bowel (enteric phase at 75 sec post gad) VIBE 3D more motion sensitive FLASH 2D, thicker slices, but relatively motion insensitive (Shiran insurance plan) Combination of FS and low SI intraluminal contrast increase the ability to detect wall enhancement Active vs fibrotic disease Bowel wall enhancement in active disease and fibrotic disease Stratification can indicate active disease Enhancing mesenteric adenopathy – sign of active disease Complications – fistulas, abscess best seen post gad

10 Pelvis – T1 axial FS, high res
Post gad T1 images are better for the pelvis than the gradient echo (VIBE and FLASH) Gas/stool in rectum degrade images thru the pelvis due to susceptibility artifact on the gradient echo images Motion is not usually a big issue in pelvis

11 MR Features IBD Transmural bowel wall thickening, thickened folds
Cobblestone Submucosal Edema – use spair images; indicates active dz Mesenteric changes Fat wrapping/creeping fat Lymphadenopathy Vascular hyperemia – comb sign Complications Strictures Fistulas Abscess ***Early disease with mucosal ulceration and nodularity is not well seen on MR***

12 Fold thickening & ulceration
Deep ulcerations – focal linear areas of high SI through thickened bowel wall Normal bowel wall and folds are low SI on both the true FISP and HASTE images

13 Deep ulcerations

14 Bowel wall thickening > 3 mm abnormal
Most patients in crohn’s 5-10 mm Marked wall thickening terminal ileum

15 Bowel wall thickening Coronal true-FISP (A) and axial HASTE (B) images shows polypoid thickening of the cecal wall (arrows). Compare this with the normal wall thickness of the descending colon (arrowhead).

16 Mesenteric changes TrueFISP Small mesenteric lymph nodes Comb sign
Small lymph nodes seen in active and chronic disease Enhancement LN suggest active disease

17 Mesenteric changes T1 and true FISP – comb sign and creeping fat

18 Mesenteric changes

19 Active vs. Chronic post contrast images
Fibrosis – low level, mild to moderate inhomogeneous enhancement Active disease – homogeneous intense enhancement or stratified enhancement

20 Ileal and appendix dz haste Post gad haste Post gad

21 Active vs Chronic Submucosal Edema
D. Martin RSNA 2007 TI post gad very sensitive for detection of IBD but spair better for determining active vs chronic Submucosal edema classic finding in active inflammation Use spair images (haste fs) to detect submucosal edema Study found many false positives for post gad T2 images better correlated with active vs inactive disease

22 Active vs Chronic haste Post gad venous -enhancing abnl loop post gad
-no edema on spair -thus FIBROTIC disease Spair/haste FS

23 Enhancement Stratified enhancement (c,d) indicative of active disease.

24 Stratified Enhancement – active disease

25 Complications - strictures
Coronal images good for looking for strictures > 3 cm bowel distention upstream indicates functional obstruction

26 Complications “Star sign” – internal fistula
Post gad Star sign of internal fistula Patient had entero-entero fistula HASTE

27 Complications – perianal dz
HASTE Fistula post gad FS post gad

28 Complications – perianal fistula
spair Post gad

29 Complications – perianal fistula on T2 images

30 Complications – perianal abscess

31 Complications – phelgmon/abscess
Post-gad trueFISP Medial wall of terminal ileum is partially indistinct and bulging medially suggesting phlegmon/early abscess.

32 Pitfalls Incomplete luminal distention
Can mimic bowel wall thickening Black border artifact on trueFISP can over estimate wall thickness use HASTE for wall thickness Intraluminal flow artifact on HASTE can simulate cobblestone Check TrueFISP Fistula can be missed since not dynamic

33 Pitfalls True FISP MR image shows extensive susceptibility artifacts generated by trapped endoluminal air Susceptibility artifact Signal dropout Bright spots Spatial distortion

34 Pitfalls – artifacts HASTE TruFISP Arrowheads – black boundary
Arrow – susceptibility artifact from trapped air *curved arrow on both – TI thickening

35 Summary Haste, trufi and post contrast images to identify abnormal bowel Coronal images good for terminal ileum, overall picture Evaluate for strictures Look for associated mesenteric changes Active vs fibrotic Haste vs spair ?submucosal edema Stratification of edema post contrast Use space, T1 post gad high res images to look for perianal disease Post contrast images for fistula, abscess

36 References Prassopoulos P, Papanikolaou N, Grammatikakis J, Rousomoustakaki M, Maris T, Gourtsoyiannis N. MR enteroclysis imaging of Crohn disease. RadioGraphics 2001;21(Spec Issue):S161–S172 Essary B, Kim J, Anupindi S, et al. Pelvic MRI in children with Crohn disease and suspected perianal involvement. Pediatr Radiol. 2007;37:201–208 Darge K, Anupindi S, Jaramillo D. MR Imaging of the Bowel: Pediatric Applications. MRI Clinics N America.2008;16(3): Toma P, Granata C, Magnano G, Barabino A. CT and MRI of paediatric Crohn disease. Pediatr Radiol. 2007;37: Greenhalgh R, Punwani S, Austin C; Halligan S, Taylor S. The MRI manifestations of small bowel Crohn’s disease revealed. Presented at RSNA Udayasankar U, Lauenstein T, Martin D. Role of SPAIR T2 fat suppressed MR imaging in active inflammatory bowel disease. Presented at RSNA 2007. Herrmann K, Michaely H, Seiderer J, et al. The “star-sign” in magnetic resonance enteroclysis: a characteristic finding of internal fistulae in Crohn's disease. Scand J Gastroenterol. 2006;41:239–241

37 Good resource
Electronic posters and papers through RSNA website Lakeside Learning Center Radiographics password

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