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Hungarian GEnomic Research on pathogenic Microbes Hu-GERM.

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Presentation on theme: "Hungarian GEnomic Research on pathogenic Microbes Hu-GERM."— Presentation transcript:

1 Hungarian GEnomic Research on pathogenic Microbes Hu-GERM

2 Centers of pahogenomic research of Hungary

3 Funding Agencies of Hu-GERM OTKA (Hungarian Scientific Research Fund) : HAS (Hungarian Academic Society) : - Invites applications on different research fields - Annual research funding 20 million Euro - Microbial pathogenomic research 500.000 Euro ETT (Medical Research Council) : - Coordinates scientific research in Hungary - the owner of 46 research institutes in the country on different fields - supports research by inviting applications

4 Running projects of Hu-GERM (2005) Studied microbes: Bacteroides spp. Chlamydia pneumoniae Clostridium difficile Enterococcus Escherichia coli Helicobacter pylori Mycobacteria Pseudomonas aeruginosa Salmonella Staphylococcus Streptococcus Yersinia

5 Topics of the 14 running projects of Hu-GERM supported by OTKA I. Attenuation of Escherichia coli by global regulatory mutations. (Emődy L.) Investigations on the pathogenicity of enteroinvasive bacteria. (Pál T.) Investigations with a regulatory mutant vaccine candidate Salmonella enterica strain eliciting cross-immunity in mice. (Nagy G.) The role of horizontal gene transfer in the evolution of enterotoxic and cytotoxic Escherichia coli bacteria. (Nagy B.) Occurence in Hungary, and molecular biological characterization of cytolethal distending toxin (CDT), a new cytotoxin.(Tóth I.) Investigations on genome-evolution and plasticity by genome reduction. (Pósfai G.) Investigations on the mechanism of human enterobacterial infections. (Győrffy Z.)

6 Topics of the 14 running projects of Hu-GERM supported by OTKA II. Multi-drug resistence types in Pseudomonas aeruginosa. (Szabó D.) In vitro and in vivo pathogenomic studies on methicillin resistant and methicillin sensitive Staphylococcus aureus strains. (Rozgonyi F.) Molecular biological studies on virulence factors of bacteria causing anaerobic infections. (Nagy E.) Cytokine gene polymorphism in diseases of microbial and complex origin. (Mándi Y.) Reactivation of mycobacteria. (Miczák. A.) Genetic background of the relationship between atherosclerosis and Chlamydia pneumoniae. (Gönczöl É.)

7 Objectives of Hu-GERM - Enhance collaboration among research groups. - Upgrade the infrastructure of pathogenomic research in Hungary. - Participation in the European ERANET-Pathogenomics Network

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