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AstaREAL® Astaxanthin for Human Health Superior Antioxidant.

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Presentation on theme: "AstaREAL® Astaxanthin for Human Health Superior Antioxidant."— Presentation transcript:

1 AstaREAL® Astaxanthin for Human Health Superior Antioxidant

2 FDA Disclaimer These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

3 Astaxanthin in Nature Astaxanthin Benefits What is Astaxanthin? Strong Antioxidant Anti-Inflammatory Provides Eye Fatigue Relief Increase Muscle Endurance Supports Healthy Blood Lipids Aids in Wrinkle Reduction

4 This Red Color in Nature is Astaxanthin

5 Antioxidant Powerful antioxidant. Potent singlet oxygen quenching and anti-lipid peroxidation activity. Anti-inflammatory Inhibition of cytokines and chemokines expression suppressing NF-kB activation *, **. Eye Health Eye fatigue *, **, Visual acuity *, **, Accommodation Sports Related Muscle endurance *, ** and damage *, **, Sports vision *. Life-style Related Diseases Hypertension *, LDL cholesterol, H. pylori *, **, Diabetes & Diabetic nephropathy *, **, Metabolic syndrome *, **. Personal Care Anti-wrinkle (topical *, ** & within *, **), Photo protectant, Melanin-inhibitor, Anti-hyperpigmentation. Biological Activities of Astaxanthin Over 50 published studies AstaREAL Published Study *AstaREAL Patented/Patent Pending

6 Cardio benefit results

7 Skin health – Anti-Aging results

8 Muscle endurance / Muscle recovery Improves Muscle Endurance Astaxanthin protects muscle at the cellular level from damage of reactive oxygen species (ROS) generated by physical activity. Astaxanthin improves blood flow and modulates vasorelaxation, protecting the endothelium dependent NO effect and vessel elastin band structure from oxidative damage Accelerates Body Fat Reduction Astaxanthin enhances fat metabolism by activating mitochondrial enzymes such as 3-hydroxyacyl CoA dehydrogenase (3-HAD) Astaxanthin protects carnitine palmitoyl transferase I (CPT I) from oxidative modification caused by ROS Reduces Lactic Acid Accumulation-Astaxanthin promotes fatty acid utilization vs glucose metabolism for Mitochondrial ATP production-Astaxanthin reduces peroxidation damage during anaerobic exercise resulting in muscle recovery time improvement

9 Eye Fatigue results Our 10 Clinical Studies Demonstrate: Increased Retinal Blood Flow Improved Accommodation Reduced Asthenopia Increased Visual Acuity Ocular Inflammation Reduction VDT Subjects with Eye Strain Symptoms before and after astaxanthin supplementation (Nagaki et al.,2002)

10 AstaREAL ® astaxanthin patents No. 6,245,818 Muscle and Physical Endurance - increased physical endurance / reduced muscle damage No. 6,262,316Gastric Health - Reduces infection/inflammation of Helicobacter pylori No. 6,335,015Mastitis - Prophylactic treatment for mastitis No. 6,410,602 Fertility - Method of increasing the production and improving the quality of semen No. 6,773,708 Immune System - Immunomodulation - autoimmune diseases and chronic viral and intracellular bacterial infections No. 6,923,967Dyspeptic Symptoms - Alleviates dyspeptic symptoms No. 7,078,040 Anti-Inflammation - Cytokine regulation - inhibiting the expression of inflammatory cytokines and chemokines Patent PendingEye Fatigue - Reduced eye fatigue / improved visual acuity Patent PendingCardiovascular – Alleviating vascular failure Patent Pending Diabetic Nephropathy - Gene expression modulator – suppression of development of diabetic nephropathy

11 Molecular Formula: C 40 H 52 O 4 Molecular Weight: CAS No: Astaxanthin -Carotene -Carotene O H O H 732 known carotenoids*732 known carotenoids* Humans cannot synthesise carotenoids.Humans cannot synthesise carotenoids. Need to obtain carotenoids from food.Need to obtain carotenoids from food. Basic carotene structureBasic carotene structure Xanthophyll ClassXanthophyll Class - Lutein - Lutein - Astaxanthin - Astaxanthin isolated and identified from isolated and identified from lobster Astacus gammarus lobster Astacus gammarus in 1938 by Kuhn in 1938 by Kuhn *G. Britton et al., Carotenoids Handbook, 2004 Member of the Carotenoid Family Lutein

12 Powerful & Safe Antioxidant - Singlet oxygen quenching -Lipid peroxidation suppressing -Without any pro-oxidative nature Astaxanthin is a Totally Unique Antioxidant Superior Position in Cell Membrane - Protection both hydrophillic & lipophillic area

13 1. Shimizu et al., Carotenoids as singlet oxygen quenchers in marine organisms, Fisheries Science, 62, (1996). 2. Nishida et al., Quenching Activities of Common Hydrophilic and Lipophilic Antioxidants against Singlet Oxygen Using Chemiluminescence Detection System, Carotenoid Science.,Vol.11: (2007) Astaxanthin is the Most Powerful Quencher of Singlet Oxygen in Nature

14 Astaxanthin does not Become Pro-Oxidant Astaxanthin does not Become Pro-Oxidant Even under Enormous Oxidative Stress H.D.Martin, et al. : Chemistry of carotenoid oxidation and free radical reactions, Pure Appl. Chem., 71(12), (1999). Why is Astaxanthin Superior?

15 Superior Position in Membrane Beta-carotene Vitamin C

16 Astaxanthin Production Haematococcus pluvialis cultivation

17 Production Haematococcus pluvialis cultivation Vegetative cell Immature Aplanospore Aplanospore μ Haematococcus Pluvialis Haemato (Blood) Coccus (Seed) Pluvialis (Fresh Water) Microalgae family – includes Chlorella and Spirulina Single cell fresh water Microalgae (Plant source) Found in standing pools and ponds world wide (non-GMO) During harsh environment conditions – Hibernates

18 Open Pond SystemOpen Pond System - Outdoor, susceptible to environmental contaminants - Outdoor, susceptible to environmental contaminants - Difficult to control unwanted foreign algae - Difficult to control unwanted foreign algae - Inconsistent production and yield - Inconsistent production and yield Closed SystemClosed System - AstaREAL Indoor closed tank system - AstaREAL Indoor closed tank system consistently has the highest yield with consistently has the highest yield with the longest history of production the longest history of production Conc. Mature ChlorophyllAstaxanthin Mass Production of Haematococcus pluvialis

19 Closed Tank System Most cost effective cultivation Total environmental control Highest quality, cleanest system First in the world to commercially cultivate Haematococcus pluvialis

20 Full Acute & Subchronic Tests NO ADVERSE SIDE EFFECTS REPORTED Ames Test & Gene Toxicity NO ADVERSE SIDE EFFECTS REPORTED Worldwide Literature Search NO ADVERSE SIDE EFFECTS REPORTED Health and Safety 30 Safety Studies. Submitted for GRAS. 1/6/2010 received FDA non-objection letter.

21 6mg is the dose


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