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Prime AGE Defense Formula Market America Convention 2009 Presented by: Jan DeBenedetto.

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Presentation on theme: "Prime AGE Defense Formula Market America Convention 2009 Presented by: Jan DeBenedetto."— Presentation transcript:

1 Prime AGE Defense Formula Market America Convention 2009 Presented by: Jan DeBenedetto

2 Disclaimer This presentation has not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

3 What are AGEs? Overview Advanced Glycation Endproducts Advanced Glycation Endproducts –Chronic high levels of AGEs are proven to accelerate the aging process –They are a diverse group of highly reactive substances –In excess can wreak havoc in the body –Many AGEs are sugar derived aldehydes (glyoxals) –They can cause generalized cellular dysfunction i.e. they can affect the entire body! i.e. they can affect the entire body! –Also known as Glycotoxins

4 AGEs - Naturally AGEs are produced naturally in normal metabolism and the body can handle low levels of AGEs AGEs are produced naturally in normal metabolism and the body can handle low levels of AGEs AGEs are consumed at a moderate level as part of a reasonably good diet AGEs are consumed at a moderate level as part of a reasonably good diet The problems occur due to the chronic overproduction and over consumption of AGEs as well as cigarette smoking The problems occur due to the chronic overproduction and over consumption of AGEs as well as cigarette smoking

5 NOTHING IN BIOLOGY MAKES SENSE EXCEPT IN THE LIGHT OF EVOLUTION Theodosius Dobzhansky -- Russian evolutionary biologist

6 Historical Perspective of AGEs Our current genome evolved on Our current genome evolved on –A low sugar diet –A low saturated fat diet –A high fiber diet –An alkaline diet –A nutrient dense diet –A chemical / drug free diet Our current genome evolved in a physically active human Our current genome evolved in a physically active human But what do we do? But what do we do? –Eat a high sugar diet –Eat a high sat fat diet –Eat a low fiber diet –Eat a chronic low acid diet –Eat lots of empty calories –Eat processed and fake foods, lots of Rx & OTCs We are much less active than our ancestors We are much less active than our ancestors

7 Historical Perspective - 2 Only within the last 200 years (a blip on the genetic radar screen) did we have simple sugars so readily available Only within the last 200 years (a blip on the genetic radar screen) did we have simple sugars so readily available –Mostly during the last 50 years We are dissonant with our genome and that aint a good thing. We are dissonant with our genome and that aint a good thing. –Dont mess with Mother Nature …

8 AGEs Can Affect the Following: Oxidative Stress Oxidative Stress Collagen cross-linking Collagen cross-linking –Wrinkles and stiffness Mitochondrial function Mitochondrial function –Cellular powerhouses Kidney function Kidney function Genetic transcription proteins Genetic transcription proteins

9 AGEs and arteries Normal diet arteryLow AGE diet artery

10 AGEs and Vertebrae

11 Glycated bone collagen

12 Excess AGEs Inside and Out The body can make AGEs The body can make AGEs Excess carbs Excess carbs Excess sugar Excess sugar Chronic stress Chronic stress Food AGEs Food AGEs –Foods cooked at high temperatures and for a long time Frying, grilling, roasting and broiling Frying, grilling, roasting and broiling Especially in presence of sugars Foods that are cooked until brown Especially in presence of sugars Foods that are cooked until brown Browning reaction or Maillard reaction generates AGEs Browning reaction or Maillard reaction generates AGEs –Carbonated non-diet beverages –Processed foods Cigarette smoking Cigarette smoking –Add AGEs to the long list of cigarette toxins

13 Why havent we hearing more about AGEs? The research is relatively new dating back to the late 80s. The research is relatively new dating back to the late 80s. Most scientific publications are from this millennia Most scientific publications are from this millennia –Out of 2373 Medline scientific literature citations, 85% are from after the year 2000! Rationale Rationale –Industry lobby efforts that negatively influenced research funding –No major Pharma companies with Rx to address issue.

14 AGEs and Aging The degree of Glycation of a cell is used as recognition signal of senescent (old/aged) targets for excretion or catabolism. The degree of Glycation of a cell is used as recognition signal of senescent (old/aged) targets for excretion or catabolism. In other words in many cases otherwise healthy cells are tagged and removed due to their being glycated and therefore will not divide into new cells. In other words in many cases otherwise healthy cells are tagged and removed due to their being glycated and therefore will not divide into new cells.

15 Smoking and AGEs AGE accumulation in the cornea of NonSmokers (NS) and Smokers (S) AGE accumulation in the cornea of NonSmokers (NS) and Smokers (S)

16 AGEs in the body Glycation leads to a large and diverse range of chemical species Glycation leads to a large and diverse range of chemical species This makes them deleterious to a variety of tissues This makes them deleterious to a variety of tissues This also makes it difficult to commercially measure AGEs at this point in time This also makes it difficult to commercially measure AGEs at this point in time –Measuring HbA1c is a good indicator Glycated Hemoglobin Glycated Hemoglobin

17 Glucose, AGEs & Time

18 Dietary AGEs Study Study –on 4 week Low AGE diet => decreased LDL by 28%! –on High AGE diet LDL increased by 50%! Study Study –6 week High AGE diet Increased LDL 33% Increased LDL 33% CRP increased 35% CRP increased 35% –6 week Low AGE diet Decreased LDL 32% Decreased LDL 32% CRP decreased 20% CRP decreased 20%

19 Dietary AGEs - 2 Rat study with two groups, Rat study with two groups, –The High AGE diet rats had higher insulin resistance, oxidative stress, inflammation renal and CV damage and lower glutathione. – The group with 50% reduced AGE diet lived significantly longer than the other group (~21%) and with lower inflammatory markers.

20 Prime AGE Defense To the Rescue! Supplement Facts Serving Size: 3 tablets Servings Per Container: 30 Amount Per Serving% Daily Value Thiamine (as Benfotiamine)55 mg4583% Taurine1,000 mg* N-acetylcysteine200 mg* American ginseng root extract (5% ginsenosides)500 mg Cinnamon bark extract250 mg* * Daily value not established.

21 Benfotiamine A lipid soluble form of Thiamine A lipid soluble form of Thiamine –This allows for greater absorption than commercial thiamine and thus higher blood level –Supports the bodys normal ability to remove AGEs –Protects endothelium (an active, vital thin layer of cells that line blood vessels) against AGEs

22 American Ginseng Panax quinquefolius Promotes normal serum levels of glucose Promotes normal serum levels of glucose Powerful Adaptogen Powerful Adaptogen Active components are ginsenosides Rb1, Rd and Re Active components are ginsenosides Rb1, Rd and Re Promotes normal levels of carboxymethyl-lysine (CML) and its receptors for (AGE) in kidney Promotes normal levels of carboxymethyl-lysine (CML) and its receptors for (AGE) in kidney

23 Cinnamon Bark Extract Promotes healthy metabolism of glucose Promotes healthy metabolism of glucose Helps maintain normal insulin sensitivity Helps maintain normal insulin sensitivity Strong antioxidant Strong antioxidant

24 N-Acetylcysteine Sulfur rich antioxidant that is a powerful antioxidant Sulfur rich antioxidant that is a powerful antioxidant Promotes healthy glutathione levels Promotes healthy glutathione levels –Glutathione is one of the bodys natural AGE scavengers Helps maintain normal levels of CML (an AGE) Helps maintain normal levels of CML (an AGE) Supports a healthy liver and kidneys Supports a healthy liver and kidneys

25 Taurine A sulfhydryl derivative of an amino acid A sulfhydryl derivative of an amino acid Found in abundance in slow twitch (endurance) muscle fibers Found in abundance in slow twitch (endurance) muscle fibers Taurine levels are typically lower with aging and vegan diets Taurine levels are typically lower with aging and vegan diets Has numerous other healthful functions Has numerous other healthful functions

26 Who can benefit most from Prime AGE Defense? Smokers Smokers Individuals who want to age well Individuals who want to age well If you indulge your sweet tooth If you indulge your sweet tooth –Eating and drinking Eat lots of Grilled, Broiled, Fried foods Eat lots of Grilled, Broiled, Fried foods Eat a lot of processed foods Eat a lot of processed foods If you have Metabolic Syndrome to any degree If you have Metabolic Syndrome to any degree

27 Complimentary Market America AGE Support Products Arginine (Ultra Prime) Arginine (Ultra Prime) Isotonix OPC-3® Isotonix OPC-3® NutriClean® Aloe/Ultimate Aloe NutriClean® Aloe/Ultimate Aloe Curcumin Extreme Curcumin Extreme Heart Health Essential Omega III Heart Health Essential Omega III Isotonix® Vitamin D with K2 Isotonix® Vitamin D with K2

28 AGE control Summary Consume a Low AGE diet Consume a Low AGE diet Help maintain healthy blood sugar levels Help maintain healthy blood sugar levels Control Stress Control Stress Exercise regularly Exercise regularly NO SMOKING NO SMOKING Take Prime AGE Defense Formula regularly! Take Prime AGE Defense Formula regularly!

29 Ultra Prime Secretagogue & Beyond!

30 Ultra Prime Supports healthy levels of human growth hormone (HGH) Supports healthy levels of human growth hormone (HGH) Functions as a secretagogue to naturally increase the production and secretion of HGH by the pituitary gland Functions as a secretagogue to naturally increase the production and secretion of HGH by the pituitary gland Recreates a youthful, natural pattern of HGH production and release into the body. Recreates a youthful, natural pattern of HGH production and release into the body. It is not HGH It is not HGH Safe and natural Safe and natural

31 Ultra Prime Powerful combination of amino acids (the natural building blocks of proteins) that have been scientifically shown to effectively raise HGH levels. Powerful combination of amino acids (the natural building blocks of proteins) that have been scientifically shown to effectively raise HGH levels. Taken with proper timing, exercise and a healthy diet you can turn back the clock and increase your HealthSpan! Taken with proper timing, exercise and a healthy diet you can turn back the clock and increase your HealthSpan!

32 Common Growth Hormone Inhibitors Stress hormones (Cortisol & Epinephrine) Stress hormones (Cortisol & Epinephrine) – Relax Insulin Insulin –Dont eat for 2 or more hours prior to bedtime Time of day Time of day –Sleep well (hGH levels rise during sleep)

33 Ultra Prime -- Key Ingredients All of the major ingredients in the Prime secretagogues have published literature supporting their potential as nuitritional HGH secretagogues. All of the major ingredients in the Prime secretagogues have published literature supporting their potential as nuitritional HGH secretagogues. BONUS!!! BONUS!!! –In addition, all of the major ingredients in these formulations have numerous other anti-aging related health benefits.

34 L-Arginine Shown to be the amino acid that enhances Nitric Oxide (NO) production (Nobel Prize work in 1998) (not Nitrous oxide – laughing gas) Shown to be the amino acid that enhances Nitric Oxide (NO) production (Nobel Prize work in 1998) (not Nitrous oxide – laughing gas) –Helps maintain healthy blood pressure –Help maintain erectile function –Help maintain healthy blood flow –Enhance Mood

35 Ultra Prime – Usage Use for hGH potentiation requires taking prior to bedtime on an empty stomach Use for hGH potentiation requires taking prior to bedtime on an empty stomach Post of a strenuous workout to enhance recovery Post of a strenuous workout to enhance recovery Other benefits can be realized taking it between meals Other benefits can be realized taking it between meals

36 Ultra Prime Top of the line hGH secretagogues Top of the line hGH secretagogues Extraordinary adjunct to support exercise Extraordinary adjunct to support exercise Excellent for nutritional support for CV health Excellent for nutritional support for CV health Great for nutritional support of basic immune function Great for nutritional support of basic immune function

37 Ultra Prime -- Summary Ultra Prime has so many more health benefits to offer you above and beyond hGH due to the unique, powerful and effective formulation Ultra Prime has so many more health benefits to offer you above and beyond hGH due to the unique, powerful and effective formulation Try it for yourself and see Try it for yourself and see


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