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Brief Cognitive Assessment based on Consensus Standards in the US and Abroad Dawn Langdon PhD.

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Presentation on theme: "Brief Cognitive Assessment based on Consensus Standards in the US and Abroad Dawn Langdon PhD."— Presentation transcript:

1 Brief Cognitive Assessment based on Consensus Standards in the US and Abroad Dawn Langdon PhD

2 MS care providers needs Most interested in receiving consultation on cognition (31.0%) Most interested in CME relating to cognition (40.1%) Highest preference for live conference Turner et al., JRRD 2006;43:25-34

3 MS patients’ information needs All those questions recommended information about cognition in MS for all patients And on average to be given earlier than they had received it Heesen et al., Acta Neurol Scand 2006;114:

4 Assessment of Cognition Comprehensive Batteries Intermediate length Batteries Brief Batteries Screening tests MSNQ BRB SEFCI MACFIMS Ad hoc Routine in the office Routine NP exam. Differential diagnosis Disability questions Rehabilitation programs 4

5 Cognitive assessment for MS Requires specialist training Time-consuming Not routinely available outside specialist centres Not comparable across countries

6 BICAMS Brief International Cognitive Assessment for MS Identify a brief assessment tool for cognition in MS – can be used by health care professionals who are not cognitive specialists – has international validation Specify an international validation protocol that can be implemented in any country Agree guidelines on test-retest timing and clinically significant change 6 BICAMS committee meetings and website are sponsored by Bayer Healthcare

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8 BICAMS Brief International Cognitive Assessment for MS Identify a brief assessment tool for cognition in MS 80 key scientific articles identified Each article rated by two committee members – Psychometric standards Reliability Validity Sensitivity – Pragmatic standards International applicability Ease of administration Feasibility in the specified context Acceptability to patients 8 BICAMS committee meetings and website are sponsored by Bayer Healthcare

9 BICAMS Brief International Cognitive Assessment for MS No materials required beyond papers, pencil and stopwatch BICAMS committee meetings and website are sponsored by Bayer Healthcare

10 Benedict et al. Clin Neuropsychol 2002; 16:

11 11 Neuropsychological Evaluations California Verbal Learning Test-II (CVLT II) Truck Spinach Giraffe Bookcase Onion Motorcycle Cabinet Zebra Coach Lamp Celery Cow Desk Boat Squirrel Cabbage Benedict et al. Clin Neuropsychol 2002; 16:

12 Brief Visuospatial Memory Test (Revised) RHB Benedict (Clin Neuropsych 1994; Psychol Assess 1996; Psychol Assess Resources 1997). Benedict et al. Clin Neuropsychol 2002; 16:

13 BICAMS Brief International Cognitive Assessment for MS Battery: SDMT CVLT-II, first recall trials BVMTR, first recall trials 13 BICAMS committee meetings and website are sponsored by Bayer Healthcare

14 MS patients compared to healthy controls on BICAMS Parmenter et al., JINS 2010;16:6-16 MS (n=395) MeanSD Controls (n=100) MeanSDP valued’ Age ns0.16 Education ns0.09 BDI-FS < SDMT < CVLT-II TL < BVMTR TL <

15 Raw score to scaled score conversion Parmenter et al., JINS 2010;16:6-16 Scaled scoreSDMTCVLT-II (learning trials)BVMTR (learning trials) 2<13 3<43< >87>7436

16 BICAMS committee meetings and website are sponsored by Bayer Healthcare

17 BICAMS Brief International Cognitive Assessment for MS Identify a brief assessment tool for cognition in MS – can be used by health care professionals who are not cognitive specialists – has international validation Specify an international validation protocol that can be implemented in any country 17 BICAMS committee meetings and website are sponsored by Bayer Healthcare

18 BICAMS Brief International Cognitive Assessment for MS international validation protocol Step 1, Standardization and Translation of Test Stimuli. Step 2, Standardization and Translation of Test Instructions Step 3, Normalization Step 4, Test-Retest Reliability Step 5, Criterion-Related Validity Benedict et al., BMC Neurology (submitted) BICAMS committee meetings and website are sponsored by Bayer Healthcare

19 BICAMS Brief International Cognitive Assessment for MS: National Validations CountryNC nMS nData collection started Data collection completed Analysis started Analysis completed Publi- cation BICAMS support ArgentinaTBD Pending RHB Benedict Czech Repub 92130Mar 2010OngoingPending RHB Benedict Iran15890Mar 2010Sep 2011Oct 2011Nov 2011Submitted RHB Benedict ArgentinaTBD Pending RHB Benedict UK60 Pending DW Langdon EgyptTBD Pending D W Langdon EstoniaTBD Pending DW Langdon ItalyTBD Pending MP Amato 19

20 BICAMS Brief International Cognitive Assessment for MS Identify a brief assessment tool for cognition in MS – can be used by health care professionals who are not cognitive specialists – has international validation Specify an international validation protocol that can be implemented in any country Agree guidelines on test-retest timing and clinically significant change 20 BICAMS committee meetings and website are sponsored by Bayer Healthcare

21 Assessment of Cognition Comprehensive Batteries Intermediate length Batteries Brief Batteries Screening tests Brief Batteries Routine in the office Routine NP exam Differential diagnosis Disability questions Rehabilitation programs 21 BICAMS Routine in the clinic 0 mins 15 mins 45 mins 90 mins 120 mins


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