2Might-A-Mins® Spectrum Isotonix® Digestive Enzymes These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
4Digestion – an overview Digestion: the process by which food is broken up physically, as by the action of the teeth, and chemically, as by the action of enzymes, and converted into a substance suitable for absorption and assimilation into the body.4 Primary ProcessesIngestionMechanical and chemical digestionAbsorptionExcretion
10Summary of Digestion Lumen of small intestine Pancreatic amylasesMaltose, other polysaccharidesPolysaccharidesProteasesPolypeptidesSmaller polypeptides (2-3 AA)Bile salts, lipasesFat globulesGlycerol, fatty acidsEpithelium of small intestineLactase, sucrase, maltaseDisaccharidesMonosaccharidesProteasesSmall peptidesAmino acids
11Might-A-Mins® Spectrum Isotonix® Digestive Enzymes DigeZyme®:Proteases → proteinsAmylases → starchesLipases → fatsCellulase → cellulose (glucose polymers)Lactase → lactose from dairySucrase – hydrolyzes sucrose into glucose and fructoseMaltase – hydrolyzes maltose into two glucose moleculesWith digestive enzymes, what we are really trying to accomplish is to break down the food we eat into the smallest molecules possible. We want to breakdown proteins into individual amino acids and starches and sugars into monosaccharides such as glucose, fructose and galactose. This is really important since we just discussed the idea that antigens are usually proteins, so if we can fully breakdown these proteins into individual amino acids, and not antigenic molecules, we can reduce some of the gastrointestinal challenges common in children and adults.Sucrase and maltase – help get glucose/fructose in early in the duodenum and not allowing to reach potential candida populations – fueling the fireSome common digestive enzymes that are used are a multienzyme complex containing [READ Multienzyme complex portion][CLICK] [READ SLIDE] Both sucrase and maltase are excreted by the villi in the small intestine. Research has shown that inflammation of the small intestine can reduce the secretion of sucrase and maltase.
12Might-A-Mins® Spectrum Isotonix® Digestive Enzymes Papain – sulfhydryl cysteine protease found naturally in papaya fruitPromotes digestion of tough meat fibersHigh enzymatic activityBromelain – mixture of enzymes found in the pumice and stems of pineapplePromotes digestion of caseinSupports a healthy digestive tractThere are some interesting fruit extracts that are rich in digestive enzymes.[READ Papain Portion]……Bromelain is a mixture of enzymes, mostly proteases that are found naturally in pineapple. It is one of the only dietary enzymes that has been shown to effectively break down casein from milk. Casein → dairy → potential antigenSupports a healthy digestive tract. It also has shown some anti-inflammatory activity. A study published just two months ago in Clinical Immunology found that bromelain can inhibit immune cell recruitment, thus reducing inflammation. [CLICK]
13Might-A-Mins® Spectrum Isotonix® Digestive Enzymes Actinidin – protease found in kiwi fruitDegrades cysteine residues in proteinsCaso-Glut – unique protease shown to promote the break down of proline-containing proteinsGlutenCaseinGlutamine – amino acidPreferred energy source for enterocytesSupports the preservation of villi barrier function[READ Actinidin Portion] Cysteine residues, or amino acids contain sulfur. Sulfur is required for some of our detoxification enzymes such as glutathione s-transferase to work properly. So the effective breakdown of cysteine amino acids, and release of sulfur, is thought to contribute to the sulfate pool that is often reduced in these children, thus improving their detoxification activity. [Summarize this idea!!][READ Caso-glut Portion] – this includes both gluten and casein which we have already discussed some of the issues involved with incomplete digestion of wheat and dairy.Glutamine is the most abundant amino acid in the body and it is a preferred energy source for enterocytes. It also aids in the preservation of villi barrier function. Studies have shown that glutamine supplementation can increase proliferation, or growth of enterocytes. [CLICK]
14What are the benefits?Supports the absorption and utilization of important nutrientsSupports normal digestionSupports the normal digestion of grains (gluten) and dairy (casein)Supports a healthy digestive tractSupports normal growth of intestinal cellsPromotes stomach comfortPromotes bowel regularity
15Who Would Benefit? Why? Enzyme Deficiency Stomach Discomfort Bowel IrregularityHyperacidity/Heart BurnMalabsorptionFood SensitivitiesPoor Diet/Processed FoodsMicrobiological Status
18ReferencesBorovicka, J., et al. Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor. Gut. 46: , 2000.Brudnak, M., et al. Enzyme-based therapy for autism spectrum disorders – Is it worth another look? Medical Hypotheses. 58(5): , 2002.Caspary, W. Physiology and pathophysiology of intestinal absorption. American Journal of Clinical Nutrition. 55: 299S-308S, 1992.Du, H., et al. Enzyme therapy for lysosomal acid lipase deficiency in the mouse. Human Molecular Genetics. 10(16): , 2001.Evans, M., et al. Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells. Journal of Nutrition. 133(10): , 2003.Furukawa, S., et al. Glutamine-enhanced bacterial killing by neutrophils from postoperative patients. Nutrition. 13(10): , 1997.Horvath, K., et al. Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics. 135(5): , 1999.Keller, J. and Layer, P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 54: 1-28, 2005.
19ReferencesKidd, P. Autism, an extreme challenge to integrative medicine. Part 1: the knowledge base. Alternative Medicine Review. 7(4): , 2002.Kidd, P. Autism, an extreme challenge to integrative medicine. Part I1: medical management. Alternative Medicine Review. 7(6): , 2002.Levy, S. and Hyman, S. Novel treatments for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews. 11: , 2005.Miller, A. Therapeutic considerations of L-glutamine: a review of the literature. Alternative Medicine Review. 4(4): , 1999.Miller, A. The pathogenesis, clinical implications, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5): , 1997.Reeds, P. and Burrin, D. Glutamine and the bowel. Journal of Nutrition. 131: 2505S-2508S, 2001.White, J. Intestinal pathophysiology in autism. Experimental Biology and Medicine. 228(6): , 2003.Yalcin, S., et al. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. Journal of Pediatric Gastroenterology and Nutrition. 38(5): , 2004.