These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Might-A-Mins ® Spectrum Isotonix ® Digestive Enzymes
Digestion – an overview Digestion: the process by which food is broken up physically, as by the action of the teeth, and chemically, as by the action of enzymes, and converted into a substance suitable for absorption and assimilation into the body. 4 Primary Processes 1. Ingestion 2. Mechanical and chemical digestion 3. Absorption 4. Excretion
Digestion – an overview
Example of Enzymatic Activity TertiaryQuaternaryPrimary Enzyme: a biomolecule that increases the rate of chemical reactions
Summary of Digestion Polysaccharides (starch, glycogen) Smaller polysaccharides, maltose Salivary amylase Proteins Small polypeptides Pepsin, HCL Fats Beginning of fat degradation Lingual lipases Oral Cavity Stomach
Summary of Digestion
Polysaccharides Maltose, other polysaccharides Pancreatic amylases Polypeptides Smaller polypeptides (2-3 AA) Proteases Fat globules Glycerol, fatty acids Bile salts, lipases Disaccharides Monosaccharides Lactase, sucrase, maltase Small peptides Amino acids Proteases Lumen of small intestine Epithelium of small intestine
Might-A-Mins ® Spectrum Isotonix ® Digestive Enzymes DigeZyme ® : DigeZyme ® : Proteases proteins Proteases proteins Amylases starches Amylases starches Lipases fats Lipases fats Cellulase cellulose (glucose polymers) Cellulase cellulose (glucose polymers) Lactase lactose from dairy Lactase lactose from dairy Sucrase – hydrolyzes sucrose into glucose and fructose Sucrase – hydrolyzes sucrose into glucose and fructose Maltase – hydrolyzes maltose into two glucose molecules Maltase – hydrolyzes maltose into two glucose molecules
Papain – sulfhydryl cysteine protease found naturally in papaya fruit Papain – sulfhydryl cysteine protease found naturally in papaya fruit Promotes digestion of tough meat fibers Promotes digestion of tough meat fibers High enzymatic activity High enzymatic activity Bromelain – mixture of enzymes found in the pumice and stems of pineapple Bromelain – mixture of enzymes found in the pumice and stems of pineapple Promotes digestion of casein Promotes digestion of casein Supports a healthy digestive tract Supports a healthy digestive tract Might-A-Mins ® Spectrum Isotonix ® Digestive Enzymes
Actinidin – protease found in kiwi fruit Actinidin – protease found in kiwi fruit Degrades cysteine residues in proteins Caso-Glut – unique protease shown to promote the break down of proline-containing proteins Caso-Glut – unique protease shown to promote the break down of proline-containing proteins Gluten Gluten Casein Casein Glutamine – amino acid Glutamine – amino acid Preferred energy source for enterocytes Preferred energy source for enterocytes Supports the preservation of villi barrier function Supports the preservation of villi barrier function Might-A-Mins ® Spectrum Isotonix ® Digestive Enzymes
What are the benefits? Supports the absorption and utilization of important nutrients Supports the absorption and utilization of important nutrients Supports normal digestion Supports normal digestion Supports the normal digestion of grains (gluten) and dairy (casein) Supports the normal digestion of grains (gluten) and dairy (casein) Supports a healthy digestive tract Supports a healthy digestive tract Supports normal growth of intestinal cells Supports normal growth of intestinal cells Promotes stomach comfort Promotes stomach comfort Promotes bowel regularity Promotes bowel regularity
Who Would Benefit? Why? Enzyme Deficiency Enzyme Deficiency Stomach Discomfort Stomach Discomfort Bowel Irregularity Bowel Irregularity Hyperacidity/Heart Burn Hyperacidity/Heart Burn Malabsorption Malabsorption Food Sensitivities Food Sensitivities Poor Diet/Processed Foods Poor Diet/Processed Foods Microbiological Status Microbiological Status
References Borovicka, J., et al. Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor. Gut. 46: , Brudnak, M., et al. Enzyme-based therapy for autism spectrum disorders – Is it worth another look? Medical Hypotheses. 58(5): , Caspary, W. Physiology and pathophysiology of intestinal absorption. American Journal of Clinical Nutrition. 55: 299S-308S, Du, H., et al. Enzyme therapy for lysosomal acid lipase deficiency in the mouse. Human Molecular Genetics. 10(16): , Evans, M., et al. Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells. Journal of Nutrition. 133(10): , Furukawa, S., et al. Glutamine-enhanced bacterial killing by neutrophils from postoperative patients. Nutrition. 13(10): , Horvath, K., et al. Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics. 135(5): , Keller, J. and Layer, P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 54: 1-28, 2005.
References Kidd, P. Autism, an extreme challenge to integrative medicine. Part 1: the knowledge base. Alternative Medicine Review. 7(4): , Kidd, P. Autism, an extreme challenge to integrative medicine. Part I1: medical management. Alternative Medicine Review. 7(6): , Levy, S. and Hyman, S. Novel treatments for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews. 11: , Miller, A. Therapeutic considerations of L-glutamine: a review of the literature. Alternative Medicine Review. 4(4): , Miller, A. The pathogenesis, clinical implications, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5): , Reeds, P. and Burrin, D. Glutamine and the bowel. Journal of Nutrition. 131: 2505S-2508S, White, J. Intestinal pathophysiology in autism. Experimental Biology and Medicine. 228(6): , Yalcin, S., et al. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. Journal of Pediatric Gastroenterology and Nutrition. 38(5): , 2004.