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Who We Are & What We Do We are a group of scientists, clinicians, researchers and business people dedicated to designing key products based on the latest.

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Presentation on theme: "Who We Are & What We Do We are a group of scientists, clinicians, researchers and business people dedicated to designing key products based on the latest."— Presentation transcript:

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2 Who We Are & What We Do We are a group of scientists, clinicians, researchers and business people dedicated to designing key products based on the latest research available today.

3 Introducing THE DAWN OF A NEW GENERATION Enhanced Vitamin C Powder The Right C ®, Riboperine ®, MultiPath ® and slogan are registered trademarks of The C Group, Inc..

4 If you aren’t taking The Right C ® … … then you’re taking the WRONG C! The Right C is a registered trademark of the C Group, Inc. Help the body to help itself with EnterCell ™ / MultiPath ® technology The Right C®, Riboperine®, MultiPath® and slogan are registered trademarks of The C Group, Inc

5 “If you aren’t taking The Right C ® … … then you are taking the WRONG C!” ® The Right C ®, Riboperine ®, MultiPath ® and slogan are registered trademarks of The C Group, Inc

6 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 6 The Right C ® Vitamin C Crystals Better absorption - up to 400% better than regular vitamin C. Stomach gentle - non acidic, pH neutral. Sodium* ascorbate used in The Right C ® enhances entry into the cells via the body’s sodium-dependent pathways. Sodium* ascorbate is different than sodium chloride – no table salt side effects. Contains 5% of our proprietary Riboperine ® metabolite complex, shown to enhance the uptake and absorption of vitamin C into the body. * The form of sodium traditionally associated with hypertension is sodium chloride, as found in table salt and many processed foods. The sodium used in The Right C ® is sodium ascorbate, which has not been associated with raising of blood pressure. A 1000 mg. dose of The Right C ® contains only 6% of the daily value for sodium (2400 mg. per day). Individuals with concerns about salt intake should, however, discuss any concerns with their healthcare practitioner.

7 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 7 The Right C ® Vitamin C Crystals (continued) Completely water soluble, allowing The Right C ® to go easily into solution for better absorption. A better form of vitamin C that can be taken in higher doses without the side effects common to many other forms of vitamin C, including gastrointestinal upset. A powerful Vitamin C with EnterCell ™ technology - "enters" the body and cells through “multiple pathways” - MultiPath ® providing several routes for vitamin C to be absorbed into the cells more rapidly. The Right C ® with Riboperine ® metabolites goes beyond other forms of Vitamin C to provide superior absorption and bioavailability to your body: means that all of the important benefits of vitamin C – including its powerful anti-oxidant activity, its role in strengthening immune system function and its importance in collagen production – are all expected to be improved. Not just a single molecule but an effective combination of nutrients formulated and manufactured to maximize the body’s potential.

8 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 8 DEVELOPMENT OF A NEW FORM OF VITAMIN C The Right C ® with EnterCell TM technology

9 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 9 The Right C ® with EnterCell TM technology The Right C ® is a special crystal form of Vitamin C with a strongly attached sodium molecule that is buffered to a non- acidic, neutral pH. This form eliminates, or greatly reduces, the normal intestinal distress that occurs with some individuals taking large amounts of Vitamin C. The sodium molecule used in this product helps with enhanced entry into the cells through EnterCell ™ technology. The Right C ®, enhanced with our special Riboperine ® Metabolites, has been tested for over two years in clinical validations and is still being used by physicians to ensure the clinical benefits of the product. Vitamin C bound to a sodium molecule has long been used by physicians for intravenous infusions and as a supplement in many foods.

10 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 10 Using Multiple Vitamin C Pathways - MultiPath ® 1.Glucose and Vitamin C are taken up into the cells by many of the same transport systems. 2.Many nutrients utilize the Glucose pathway for absorption. The Right C ® with Riboperine ® Metabolites does not use only the Glucose pathway exclusively for transport into the cell, but uses multiple, entirely different, separate and unique pathways - MultiPath ®. The Right C ® with Riboperine ® Metabolites does not have to “wait in line" to be absorbed into the cell. 3.The Right C ® has been formulated to enter the cells from several pathways, i.e., the Glucose pathway, the Sodium pathway, the mass action pathway and transport facilitated by the Pentose Phosphate Shunt, rather than just the Glucose/Ascorbate pathway.

11 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 11 Metabolism Pathways within Cells The diagram below illustrates a few of the most important sources of energy available to cells.

12 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 12 Metabolism Pathways within Cells

13 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 13

14 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 14

15 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 15 Metabolism Pathways within Cells

16 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 16 Research Studies

17 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 17 Oral Absorption Study Of Vitamin C Supplements in Guinea Pigs

18 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 18 Oral Absorption Study Of Vitamin C Supplements in Guinea Pigs PURPOSE To determine the plasma total ascorbate levels in guinea pigs after oral gavage with Ascorbic Acid (AA), Another Vitamin C (AVC) or The Right C ® (TRC) at a dose of 8 mgs/kg body weight as equivalent ascorbate activity (human dose equivalent of 560 mgs.)

19 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 19 Oral Absorption Study Of Vitamin C Supplements in Guinea Pigs PROCEDURES Thirty albino guinea pigs depleted of ascorbate prior to administration of test materials. Samples obtained at 0, 30, 60 and 90 minutes post-administration HPLC was used to analyze plasma samples for total ascorbate activity. Ascorbate recovery was 99.2% and the RSD 4.3%

20 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 20 Oral Absorption Study Of Vitamin C Supplements in Guinea Pigs RESULTS The mean total ascorbate concentrations in micrograms/ml are given in the table below. 0306090 minutes A A ---0.310.640.46 AVC ---1.020.490.25 The Right C ® ---1.400.870.64 Control0.17 The Data Are Graphically Presented in The Attached Figure..

21 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 21 DISCUSSION OF RESULTS

22 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 22 The Right C ® attained the highest total ascorbate plasma level at 30 minutes post-dose.

23 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 23 Compared to AVC, The Right C ® ascorbate plasma levels rose 41% higher at 30 minutes. 41 % Higher than AVC

24 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 24 The Right C ® ascorbate plasma levels were 414% higher than Ascorbic Acid at 30 minutes while AVC was only 260% higher. 414 % Higher than Ascorbic Acid

25 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 25 At 60 minutes, The Right C ® plasma ascorbate levels were 71%, and at 90 minutes, 160% higher than levels produced by AVC.

26 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 26 At 60 and 90 minutes, the plasma ascorbate concentrations for AVC fell below both The Right C ® and Ascorbic Acid.

27 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 27 Extrapolation (fourth points) predicts that AVC plasma ascorbate levels return to baseline/control levels at ca. 105 minutes; Ascorbic Acid at 120 minutes; and The Right C ® at 180 minutes post-dose.

28 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 28 The AUC (area under the curve) for The Right C ® is in the range of 175% greater than the AVC AUC and 200% greater than Ascorbic Acid.

29 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 29 The AUC is a measure of the Total Ascorbate Activity delivered to the blood (plasma) and absorbed over the test period.

30 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 30 Oral Absorption Study Of Vitamin C Supplements in Guinea Pigs CONCLUSIONS At equal ascorbate activity, The Right C ® produces the highest plasma levels The Right C ® ascorbate plasma levels are maintained for the entire test period The Right C ® delivers 175% more ascorbate activity than AVC This delivery is due to a more rapid oral uptake of The Right C ® (based on down slopes until return to baseline)

31 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 31 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study

32 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 32 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study PURPOSE To determine the rate of oral absorption of The Right C ® (TRC) and Another Vitamin C (AVC) by analysis of Total Vitamin C (ascorbic acid, AA) delivered to plasma at 90 minutes post-ingestion.

33 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 33 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study STUDY DESIGN 10 healthy male subjects were randomized into two groups as described below. They were to refrain from taking any vitamin supplements for at least 7 days prior to the start of the study. They were to avoid intake of fruits and vegetables prior to and during the study period. The study grouping consisted of two groups: Subjects were designated in The Right C ® group, TRC1 - TRC5; in the AVC group, AVC1 - AVC5. After cross-over the group designations were reversed. The study required that all subjects fast prior to beginning the study.

34 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 34 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study STUDY DESIGN (continued) The AVC subjects received 1000 mgs of AVC orally. Just prior to ingestion, a blood sample was collected in a heparin vacutainer tube. Plasma was obtained and preserved with meta-phosphoric acid and frozen for analysis. This time period served to establish baseline levels of plasma AA mg/L for each subject. After ingestion of the test product, subjects were bled at 30 min., 60 min. and 90 minutes. The TRC subjects were treated in similar fashion except they received 1000 mgs of The Right C ® orally. Blood samples were handled in the same way.

35 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 35 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study STUDY DESIGN (continued) The subjects from both groups were washed out and groups crossed-over and the procedures repeated. The phase before the cross-over was required to determined the inherent absorption characteristics unique to each subject independent of test material and to establish plasma AA baselines to be used in calculating the rate of absorption or uptake for each test material after cross-over.

36 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 36 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study ASCORBATE ANALYSIS Plasma AA was analyzed by High Pressure Liquid Chromatography. All results are expressed as mgs Total AA per liter of plasma at each time period (mg AA/L ).

37 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 37 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study RESULTS Cross-over data indicates that increased AA plasma levels observed in TRC subjects at 90 min. were due to increased rate of absorption of The Right C ® and not due to individual subject effects. The increased AA plasma levels of AA in the TRC group compared to the AVC group was due to The Right C ® formulation (see Table 1).

38 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 38 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study RESULTS – Table 1 Test MaterialAA mg/LSE MeanRange The Right C ® *11.61 0.8810 - 13 AVC 6.22 1.20 5 – 8 Average Increase, above baseline, in Total Plasma AA (mg/L) at 90 minutes after ingestion of test material *p ≤ 0.05

39 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 39 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study RESULTS Absorption rate or uptake rate was calculated and is graphically shown in Figure 1

40 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 40

41 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 41 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study RESULTS – Figure 1 Initial uptake rate for The Right C ® at 30 min. was 30% faster compared to AVC. This absorption rate increased, at 90 min., to 196%. This means that the absorption or uptake rate of The Right C ® was 196% greater than the rate of uptake for AVC. This increased uptake rate for The Right C ® is the mechanism by which The Right C ® makes AA more rapidly absorbed and raises AA plasma levels more rapidly and higher than AVC. The rate (R) for The Right C ® is 0.132 mg/L/ min.; for AVC it is 0.067 mg/L/ min. Extrapolation to 4 hrs indicates that The Right C ® would deliver 32 mg AA/L plasma while AVC only 16 mg AA/L plasma. At 4 hours, The Right C ® AUC (area under the curve) is approximated to be 205% greater than the AUC for AVC.

42 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 42 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study RESULTS & DISCUSSION The data indicate that The Right C ® formulation is absorbed more rapidly than AVC by 196%. The Right C ® raises plasma AA levels more rapidly and higher than AVC. Higher plasma levels promote more rapid increases in intracellular AA. Higher AA levels enable the cell to utilize AA at a higher rate in cell metabolism and provides superior anti-oxidant action in the plasma as well as the cell. On a whole blood basis, The Right C ® increases a liter of whole blood by 34.9 mg AA in four hours, while AVC only increases this parameter by 7.7 mg per liter.

43 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 43 A Preliminary Human Study to Determine the Bioavailability of The Right C ® (TRC) and Another Vitamin C (AVC) in a Blinded Cross-over Study This report was prepared for The C Group, Inc. by: Anthony J. Verlangieri, Ph.D., F.A.C.N., D.A.B.F.E. (Fellow) Professor of Pharmacology and Toxicology

44 THE C GROUP, INC.. 4960 S Gilbert Rd #1-135. Chandler, AZ 85249-6003. 480-809-6869 44 Some of our Distributors: In the USA Doctor C 928.263.6222 Email: sales@doctorconline.com Website: doctorconline.com In Canada Vero Nutraceuticals Corp 604.220.7764 Email: hrondeau@verocorp.com In Indonesia PT. Radiant Sentral Nutrindo 021.569.43355 Email: custservice@nutrindo.com

45 THE DAWN OF A NEW GENERATION Enhanced Vitamin C Powder The Right C ®, Riboperine ®, MultiPath ® and slogan are registered trademarks of The C Group, Inc

46 “If you aren’t taking The Right C ® … … then you are taking the WRONG C!” ® The Right C ®, Riboperine ®, MultiPath ® and slogan are registered trademarks of The C Group, Inc

47 European Distribution


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