28ER exit site50nm vesicle> 200 mem proteinCargo Recruitment
29Only proteins that are properly folded and assembled can leave the ER IncompleteER resident protein
30Defect in Cl- transport CF (Cystic fibrosis)Defect in Cl- transportThis is not because the mutation inactivated the protein,But because the active protein is discarded before itreaches the plasma membrane.
31Transport from the ER to the Golgi apparatus is mediated by vesicular tubular clusters.Heterotypic fusionHomotypic memb fusion is not restricted to form VTC.
32The structure formed when ER-derived vesicles fuse with one another are called.
43High specificendoglycosidaseCan distinguish betweenthese two type
44Proteoglycans are assembled in the Golgi Apparatus O-linked glycosylationProteoglycans are secreted or anchored to plasma membrane
45What is the purpose of N-glycosylation? 1. N-linked is prevalent in all eukaryotes, but absent in procaryotes.2. limited flexibility.3. Recognition4. Regulation of development5. Protective coat unit6. Cell-cell adhesion
93Chapter 13 practiceThe endocytic and biosynthetic-secretory and retrieval pathway.Utilization of different coats in vesicular traffic.The role of SNAREs and SNAREs-interacting proteins in vesicle transport .The traffic role of COPI &COPII coat shuttling between Golgi and ER.What is KDEL signal and its role in retrieval pathway.How to distinguish between the high-mannose oligosaccharide and complex oligosaccharide.Write the full name for Glc NAc, NANA(sialic acid).The functional compartmentization of Golgi apparatus.Three pathways to degradation in lysosomes.How to transport lysosomal enzyme to lysosome from ER.Possible fates for endocytosed transmembrane receptor proteins.The receptor-mediated endocytosis of LDL.Three best-understanding pathways of protein sorting in trans Golgi.