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Avamys fits the receptor pocket perfectly Avamys has been designed to go into the alpha pocket of the glucocorticoid receptor Avamys unique structure has.

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Presentation on theme: "Avamys fits the receptor pocket perfectly Avamys has been designed to go into the alpha pocket of the glucocorticoid receptor Avamys unique structure has."— Presentation transcript:

1 Avamys fits the receptor pocket perfectly Avamys has been designed to go into the alpha pocket of the glucocorticoid receptor Avamys unique structure has been designed to fully occupy the glucocorticoid receptor pocket as completely as possible 1 1 1

2 Avamys is the first INS to show such a high binding with the glucocorticoid receptor All INS bind to the glucocorticoid receptor in the same way and to the same degree Avamys shows effective binding with the glucocorticoid receptor No other INS will ever bind to the receptor better than Avamys Avamys is the first INS to show perfect binding with the glucocoticoid receptor

3 Avamys is more effective than any other INS because it binds more strongly to the receptor and stays bound Avamys stays bound to the glucocorticoid receptor for longer than other INS Avamys binds effectively to the receptor overtime

4 Avamys has a higher affinity for the receptor than Nasonex and hence is more effective than Nasonex Avamys has a high affinity compared to other INS. Avamys has the highest affinity compared to other INS 4 4 4

5 The enhanced affinity & extended tissue association of Avamys means that it could be expected to lead to greater & more prolonged anti-inflammatory effects compared to other INS Whilst Avamys has enhanced affinity and extended tissue association, it is impossible to speculate whether this might have any clinical implications. The enhanced affinity of Avamys is an unique pharmacological property of Avamys. The enhanced affinity means that Avamys is the strongest anti-inflammatory molecule compared to other INSs. The unique pharmacokinetic properties of Avamys mean it is the most effective INS currently available

6 Avamys – leading the INS evolution Statement 1Statement 2Statement 3 Statement 4 Statement 5


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