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Echocardiographic Evaluation of Constrictive Pericarditis Angela Morello, M.D. December 18, 2007.

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Presentation on theme: "Echocardiographic Evaluation of Constrictive Pericarditis Angela Morello, M.D. December 18, 2007."— Presentation transcript:

1 Echocardiographic Evaluation of Constrictive Pericarditis Angela Morello, M.D. December 18, 2007

2 The Pericardium Fibroelastic sac surrounding heart Fibroelastic sac surrounding heart Composed of 2 layers: serous parietal and fibrous visceral pericardium Composed of 2 layers: serous parietal and fibrous visceral pericardium Forms a sac-like potential space: contains thin layer of fluid (5-10 cc) Forms a sac-like potential space: contains thin layer of fluid (5-10 cc)

3 The Pericardium: Pericardial reflections: surround pulmonary and systemic inflow and great vessels Pericardial reflections: surround pulmonary and systemic inflow and great vessels Transverse sinus: great arteries posteriorly Transverse sinus: great arteries posteriorly Oblique sinus: posterior to LA between pulmonary veins Oblique sinus: posterior to LA between pulmonary veins

4 Constrictive Pericarditis: Pericardium becomes thickened and fibrotic Pericardium becomes thickened and fibrotic Loss of elasticity and compliance Loss of elasticity and compliance Can follow (usually late) any pericardial inflammatory process Can follow (usually late) any pericardial inflammatory process

5 Etiologies: Idiopathic or Viral: % Idiopathic or Viral: % Post cardiac surgery: % Post cardiac surgery: % Post Radiation: 9-31% Post Radiation: 9-31% CT disease: 3-7% CT disease: 3-7% Postinfectious: 3-6% Postinfectious: 3-6% TB TB Bacterial/purulent Bacterial/purulent Others: 1-10% Malignancy Trauma Asbestosis Sarcoidosis Drugs Uremia

6 Physiology of Constriction: Rapid early diastolic filling Rapid early diastolic filling Impaired late diastolic filling due to Impaired late diastolic filling due to inelastic pericardium inelastic pericardium Pericardium acts as a calcified shell: Pericardium acts as a calcified shell: Decreased compliance: fills to a point and abruptly stops Decreased compliance: fills to a point and abruptly stops Pressure/Volume changes within the heart affect other chambers: Interdependence Pressure/Volume changes within the heart affect other chambers: Interdependence Nothing gets in: Intrathoracic pressures not transmitted to cardiac chambers and encased great vessels Nothing gets in: Intrathoracic pressures not transmitted to cardiac chambers and encased great vessels

7 Hemodynamics: CVP tracing: Rapid descent of RAP with ventricular filling (y descent) CVP tracing: Rapid descent of RAP with ventricular filling (y descent)

8 Hemodynamics: Ventricular tracing: rapid early diastolic filling with abrupt halt and plateau: Ventricular tracing: rapid early diastolic filling with abrupt halt and plateau: Square-root sign Square-root sign Dip-and-plateau Dip-and-plateau Equalization of diastolic pressures Equalization of diastolic pressures

9 Respiratory Hemodynamics: Intrathoracic pressure not transmitted to cardiac chambers Intrathoracic pressure not transmitted to cardiac chambers Right-sided venous return does not increase as significantly with inspiration: Right-sided venous return does not increase as significantly with inspiration: Increase in RV inflow across TV Increase in RV inflow across TV Pulmonary venous pressure still decreases with inspiration: Pulmonary venous pressure still decreases with inspiration: Decrease in LV inflow across MV Decrease in LV inflow across MV

10 Goldstein J. Curr Probl Cardiol 2004.

11 Respiratory Hemodynamics: Increased Interdependence of RV and LV: Increased Interdependence of RV and LV: Inspiration: Right-sided filling > Left-sided filling Inspiration: Right-sided filling > Left-sided filling LV output is minimized by decreased inflow LV output is minimized by decreased inflow RV septum bows into LV  further decrease in CO RV septum bows into LV  further decrease in CO Result: Result: Decrease in LV systolic pressure Decrease in LV systolic pressure Relative increase in RV systolic pressure Relative increase in RV systolic pressure

12 Inspiratory Discordance:

13 Discordance vs Concordance: Grossman, th edition.

14 Echocardiographic Evaluation: Preferred modality for assessing the pericardium and pericardial disease Preferred modality for assessing the pericardium and pericardial disease Less reliable that MR or CT for pericardial thickening, calcification, or constriction Less reliable that MR or CT for pericardial thickening, calcification, or constriction Still employed as initial diagnostic test Still employed as initial diagnostic test Recommended by the ACC/AHA Recommended by the ACC/AHA

15 Normal Pericardium: M-Mode: M-Mode: Systolic separation of the visceral and parietal pericardium Systolic separation of the visceral and parietal pericardium 2 layers move in parallel 2 layers move in parallel Two-Dimensional: Two-Dimensional: Brightest structure Brightest structure Heart/Visceral pericardium slide/twist within the parietal pericardium Heart/Visceral pericardium slide/twist within the parietal pericardium

16 M-Mode

17 M-Mode: Constriction Dense-echos posterior to LV: Dense-echos posterior to LV: Move in parallel Move in parallel Abrupt, posterior motion of the ventricular septum in early diastole (dip): Abrupt, posterior motion of the ventricular septum in early diastole (dip): Flat in mid-diastole (plateau with equal RV and LV) Flat in mid-diastole (plateau with equal RV and LV) Abrupt anterior motion in atrial contraction (RV filling) Abrupt anterior motion in atrial contraction (RV filling) IVC and hepatic vein dilatation IVC and hepatic vein dilatation

18 Normal Pericardium:

19 2D: Constriction Increased echogenicity of the pericardium from thickening Increased echogenicity of the pericardium from thickening Loss of movement of heart within pericardium: Loss of movement of heart within pericardium: Fixed and adherent Fixed and adherent May see effusion (effusive-constrictive) May see effusion (effusive-constrictive) Septal shudder or bounce Septal shudder or bounce Abrupt posterior movement of septum Abrupt posterior movement of septum In inspiration with underfilling of LV In inspiration with underfilling of LV

20 Fixed& echogenic pericardium:

21 Pericardial thickening:

22 Subcostal:

23 Septal Bounce:

24

25

26 Other 2D Findings: Dilation of IVC Dilation of IVC Decreased collapse of IVC w/ inspiration Decreased collapse of IVC w/ inspiration Hepatic vein plethora Hepatic vein plethora Biatrial enlargement Biatrial enlargement Abrupt stop in diastolic filling of ventricles Abrupt stop in diastolic filling of ventricles

27 Doppler Echocardiography: Crucial component in the evaluation of constriction Crucial component in the evaluation of constriction Corresponds with the physiology and reflects the hemodynamics previously discussed Corresponds with the physiology and reflects the hemodynamics previously discussed

28 Doppler Findings: RV and LV inflow show prominent E wave due to rapid early diastolic filling Short deceleration time of E wave as filling abruptly stops Small A wave as little filling occurs in late diastole following atrial contraction Otto. Textbook of Clinical Echocardiography, 3 rd Edition, 2004.

29 Doppler Findings: Redfield MM, et al. JAMA 2003.

30 Review of Doppler: Pulmonary vein flow (on apical 4 chamber): Pulmonary vein flow (on apical 4 chamber): Correspond to LA filling Correspond to LA filling Prominent a wave Prominent a wave Prominent y descent Prominent y descent Prominent diastolic filling phase Prominent diastolic filling phase Blunted systolic filling following atrial contraction Blunted systolic filling following atrial contraction

31 Doppler: Mitral and Tricuspid Inflow Marked respiratory variation in biventricular inflow Marked respiratory variation in biventricular inflow Inspiration: Inspiration: Negative intrapleural pressure Negative intrapleural pressure Increased RV inflow velocity and diastolic filling Increased RV inflow velocity and diastolic filling Decreased LV inflow velocity Decreased LV inflow velocity Greater than 25% respiratory variation Greater than 25% respiratory variation

32 Mitral Inflow: Turkish Society of Cardiology, CXR:Transmitral Doppler:

33 Respiratory Mitral Inflow:

34

35 Respiratory Tricuspid Inflow:

36 Tissue Doppler: Important in differentiating restriction and constriction Important in differentiating restriction and constriction Prominent E’, Loss of A’ Prominent E’, Loss of A’ Gorcsan, J. Japanese Circ Society, 2000

37 Tissue Doppler: Annular Paradox: Annular Paradox: E/E’ increased E/E’ increased Mean LAP decreased Mean LAP decreased High pressure and low ratio High pressure and low ratio Peak E’ ≥ 8 cm/s: (Rajagopalan, N. at al. AJC 2001.) Peak E’ ≥ 8 cm/s: (Rajagopalan, N. at al. AJC 2001.) 89% senstive for constriction 89% senstive for constriction 100% specific 100% specific

38 Improving Sensitivity: Choi et al. J Am Soc Echo, 2007 Jun. Choi et al. J Am Soc Echo, 2007 Jun. To evaluate additional value of systolic mitral annular velocity (S’) and time difference between onset of mitral inflow (T(E’-E)) and onset of E’ to differentiate constriction and restriction To evaluate additional value of systolic mitral annular velocity (S’) and time difference between onset of mitral inflow (T(E’-E)) and onset of E’ to differentiate constriction and restriction

39 Normal Tissue Doppler: Nurcan,et al. Turkish Society of Cardiology, 2006.

40 The Study: 44 patients: 44 patients: 28 male, 16 female 28 male, 16 female Mean age 47 years (10-76 years) Mean age 47 years (10-76 years) 17 patients with constrictive pericarditis 17 patients with constrictive pericarditis 12 patients with restrictive cardiomyopathy 12 patients with restrictive cardiomyopathy 15 control subjects 15 control subjects Standard mitral inflow doppler and tissue doppler performed Standard mitral inflow doppler and tissue doppler performed

41 Study Results: Constriction: Constriction: E’ 9.5 +/- 1.7 cm/s E’ 9.5 +/- 1.7 cm/s S’ 7.7 +/-1.3 cm/s S’ 7.7 +/-1.3 cm/s T(E-E’) /- 32 ms T(E-E’) /- 32 ms Restriction: E’ 4.7 +/- 1.6 cm/s S’ 4.6 +/- 1.9 cm/s T(E-E’) / ms ●E’ and S’ significantly higher in constrictive group: (P< 0.001) ●T(E-E’) significantly shorter in constrictive group: (P= 0.02)

42 Study Results: Diagnostic accuracy of E’ > S’ >T(E-E’) for differentiation of constriction vs restriction: Diagnostic accuracy of E’ > S’ >T(E-E’) for differentiation of constriction vs restriction: AUC: 0.99 vs 0.87 vs 0.74, resp. AUC: 0.99 vs 0.87 vs 0.74, resp. E’ of 8 cm/s: 100% specific, 70% sensitive at differentiation E’ of 8 cm/s: 100% specific, 70% sensitive at differentiation

43 Study Results: Combining E’ with S’ and T(E-E’): Combining E’ with S’ and T(E-E’): Sensitivity increased compared to E’ alone: Sensitivity increased compared to E’ alone: 70% sensitive with E’ alone 70% sensitive with E’ alone 88% sensitive with E’ + S’ 88% sensitive with E’ + S’ 94% sensitive with E’ + S’ + T(E-E’) 94% sensitive with E’ + S’ + T(E-E’) P = P = 0.001

44 Study Conclusion: Additional Measurement of S’ and T(E-E’) can be incrementally helpful in differentiation of constrictive pericarditis from restrictive cardiomyopathy when added to E’ Additional Measurement of S’ and T(E-E’) can be incrementally helpful in differentiation of constrictive pericarditis from restrictive cardiomyopathy when added to E’

45 Other Echo techniques: Rajagopalan, et al. Am J Cardiol 2001: Rajagopalan, et al. Am J Cardiol 2001: Evaluate Tissue Doppler and Color M-Mode flow propagation to distinguish CP and RCM Evaluate Tissue Doppler and Color M-Mode flow propagation to distinguish CP and RCM 30 patients: 30 patients: 19 Constrictive pericarditis 19 Constrictive pericarditis 11 Restrictive cardiomayopathy 11 Restrictive cardiomayopathy Confirmed by other modalities Confirmed by other modalities Compared with mitral inflow respiratory variation Compared with mitral inflow respiratory variation

46 Propagation Velocity: Color M-Mode of diastolic flow from LA to apex in 4 chamber view Color M-Mode of diastolic flow from LA to apex in 4 chamber view 20 by TTE, 10 by TEE 20 by TTE, 10 by TEE Flow propagation slope of first aliasing contour (white line): Flow propagation slope of first aliasing contour (white line): Steep at 110 cm/s in CP Steep at 110 cm/s in CP Less steep at 35 cm/s in RCM Less steep at 35 cm/s in RCM Rajagopalan N. Am J Cardiol 2001;87:86

47 Results: Slope of first aliasing contour of > 100 cm/s differentiated CP from RCM: Slope of first aliasing contour of > 100 cm/s differentiated CP from RCM: 91% specificity 91% specificity 74% sensitivity 74% sensitivity

48 Other Results: Respiratory variation of the mitral inflow peak early velocity of ≥10%: 84% sensitivity and 91% specificity Respiratory variation of the mitral inflow peak early velocity of ≥10%: 84% sensitivity and 91% specificity Variation in the pulmonary venous peak diastolic velocity of ≥18%: 79% sensitivity and 91% specificity Variation in the pulmonary venous peak diastolic velocity of ≥18%: 79% sensitivity and 91% specificity Tissue Doppler peak E’ of ≥8.0 cm/s: 89% sensitivity and 100% specificity. Tissue Doppler peak E’ of ≥8.0 cm/s: 89% sensitivity and 100% specificity.

49 Echo is still not perfect…. Other modalities to aid in diagnosis of constrictive pericarditis: Other modalities to aid in diagnosis of constrictive pericarditis: CXR CXR CT CT CMR CMR Cardiac catheterization Cardiac catheterization Surgical biopsy Surgical biopsy

50 Multislice Cardiac CT: Langher, et al. Heart 2006.

51 Cardiac MR: Normal Pericardium

52 Cardiac MR: Constrictive Pericarditis

53 Thanks!


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