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Glycolysis Krebs Cycle  Transition of Glycolysis to Krebs Cycle : 1) Pyruvates enter mitochondria 2) Pyruvates converts to Acetyl CoA via. transport.

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Presentation on theme: "Glycolysis Krebs Cycle  Transition of Glycolysis to Krebs Cycle : 1) Pyruvates enter mitochondria 2) Pyruvates converts to Acetyl CoA via. transport."— Presentation transcript:

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2 Glycolysis Krebs Cycle  Transition of Glycolysis to Krebs Cycle : 1) Pyruvates enter mitochondria 2) Pyruvates converts to Acetyl CoA via. transport proteins

3 Glycolysis Krebs cycle Transition from Glycolysis to Krebs cycle :->Acetyl CoA

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5 0xidized

6 Glycolysis Krebs cycle Transition from Glycolysis to Krebs cycle :->Acetyl CoA

7 X 2

8 The Krebs Cycle:  Occurs in the matrix of the mitochondria Pyruvate from glycolysis is converted to acetyl Co A and metabolized Krebs Cycle As a result of the transition to Krebs Cycle :  2 Pyruvate  2 Pyruvate -- > 2 acetyl CoA (therefore Kreb’s will run TWO turns of the Krebs cycle for each original glucose molecule!!!)  2 NADH  2 NADH & 2 CO 2

9 The Krebs Cycle:  Occurs in the matrix of the mitochondria Pyruvate from glycolysis is converted to acetyl Co A and metabolized Krebs Cycle The Krebs Cycle:  Occurs in the matrix of the mitochondria.

10 The Krebs Cycle:  Occurs in the matrix of the mitochondria Pyruvate from glycolysis is converted to acetyl Co A and metabolized Krebs Cycle The Krebs Cycle:  Occurs in the matrix of the mitochondria.  8 steps Pyruvates Acetyl CoA remember: Pyruvates (from glycolysis) have been converted to Acetyl CoA, THIS will now be metabolized.

11 1) Acetyl CoA Oxaloacetate 1) Acetyl CoA joins to the 4 carbon compound Oxaloacetate = c-c-c-c-c-c

12 now Citrate S-CoA removed = now Citrate

13 2) H 2 O given off & added ISOMER

14 CO 2 3) CO 2 is given off c-c-c-c-c oxidized --> NADH + H +  Ketoglutarate NAD+ --> NADH + H + -->  Ketoglutarate

15 CO 2 4)CO 2 is given off c-c-c-c oxidized via. NAD+ --> NADH CoA attaches --> Succinyl CoA

16 5) CoA given off phosphate group given to ADP via. GTP ADP --> ATP Succinate

17 6) 2 Hydrogens reduce FAD FAD --> FADH 2 Fumarate

18 7) Addition of H 2 O -->Malate

19 8) NAD + --> NADH Oxalocet ate reduced Oxalocet ate

20  Products  Products = 3 NADH X2 1 FADH 2 X2 2 CO 2 X2 1 ATP X2 2ATP 2FADH 2 6NADH

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22 Electron Transport Chain Electron Transport Chain :  Occurs in the cristae (folds) of inner membrane of mitochondria. 34 ATPs end result = 34 ATPs

23 Electron Transport Chain Electron Transport Chain:  How does it work… 1)HIGH ENERGY electrons “shuttle” from one “acceptor molecule” to another.

24 This “collection” of proteins that are structurally linked

25 Electron Transport Chain Electron Transport Chain:  How does it work… 1)HIGH ENERGY electrons “shuttle” from one acceptor molecule to another. At each “stop”, e-’s are transferred between molecules- they are reduced and then oxidized

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28 Electron Transport Chain Electron Transport Chain :  How does it work… OxygenThe last molecule in the chain passes e-’s to Oxygen--> VERY electronegative. Oxygen then “picks up” 2 H + --> H 2 O.

29 Electron Transport Chain Electron Transport Chain : these electron transferers -> fuel the pumping of H + from the mitochondrial matrix to the inner membrane space

30 Electron Transport Chain Electron Transport Chain : H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+

31  ATP synthase= ENZYME Inner membrane space Matrix

32  ATP synthase= ENZYME It’s a “mill” INTERMEMBRANE SPACE H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ ATP MITOCHONDRAL MATRIX ADP + A rotor within the membrane spins as shown when H + flows past it down the H + gradient. A stator anchored in the membrane holds the knob stationary. A rod (or “stalk”) extending into the knob also spins, activating catalytic sites in the knob. Three catalytic sites in the stationary knob join inorganic phosphate to ADP to make ATP. P

33 Energy, b/c of the H + gradient.. That is chemiosmot ic to the educated student!!, powers the “mill”. Inner membrane space

34 electrons are “grabbed” and H +’ s are “squirted” into the inner mitochondrial space.

35 The electron transport chain thus establishes a proton gradient across the inner mitochondrial membrane.

36 Chemiosmosis: potential energy stored in the gradient is released and captured to form ATP from ADP and phosphate via the enzyme: ATP Synthase.

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38 34 ATP’s result!! Every 1 NADH -> 3ATP Every 1 FADH 2 -> 2ATP

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44 Lets practice…

45 Are the pieces coming together?


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