* Normal Peripheral Nerve * Normal Skeletal Muscle A. General Reactions of the Motor Unit 1. Segmental Demyelination 2. Axonal Degeneration and Muscle Fiber Atrophy 3. Nerve Regeneration and Reinnervation of Muscle 4. Reactions of the Muscle Fiber
B. Diseases of Peripheral Nerve 1. Inflammatory Neuropathies * Immune-Mediated Neuropathies 2. Infectious Polyneuropathies * Leprosy * Diphtheria * Varicella-Zoster Virus 3. Hereditary Neuropathies * Hereditary Motor and Sensory Neuropathy Type 1 * Other Hereditary Motor and Sensory Neuropathies
Cont….. 4. Acquired Metabolic and Toxic Neuropathies * Peripheral Neuropathy in Adult-Onset Diabetes Mellitus * Metabolic and Nutritional Peripheral Neuropathies * Neuropathies Associated with Malignancy * Toxic Neuropathies 5. Traumatic Neuropathies 6. Tumors of Peripheral Nerve C. Diseases of Skeletal Muscle 1. Denervation Atrophy * Spinal Muscular Atrophy (Infantile Motor Neuron Disease)
A.Bones 1.Bone Modeling and Remodeling 2.Bone Growth and Development 3.Developmental (Genetic) and Acquired Abnormalities in Bone Cells, Matrix, and Structure 3.1 Malformations and Diseases Caused by Defects in Nuclear Proteins and Transcription Factors 3.2 Diseases Caused by Defects in Hormones and Signal Transduction Mechanisms 3.3 Diseases Associated with Defects in Extracellula Structural Proteins * Type 1 Collagen Diseases (Osteogenesis Imperfecta) * Type 2,10, and 11 Collagen Diseases
Cont……. 3.4 Diseases Associated with Defects in Folding and Degradation of Macromolecules * Mucopolysaccharidoses 3.5 Diseases Associated with Defects in Metabolic Pathways (Enzymes, Ion Channels, and Transporters) * Osteopetrosis 3.6 Diseases Associated with Decreased Bone Mass * Osteoporosis 3.7 Diseases Caused by Osteoclast Dysfunction * Paget Disease (Osteitis Deformans)
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