6 The phospholipid bilayer is the fundamental structure of the membrane The cell membrane contains both hydrophilic and hydrophobic regions
7 Two types of proteins in membranes – peripheral proteins and integral proteins
8 4. The Synaptic cleft is a tiny gap or space between the axon terminal and the cell membrane (or more specifically the sarcolemma)
9 5. The acetylcholine diffuses across the cell membrane and binds to receptor proteins on the cell membrane allowing the polar membrane to become permeable to sodium, depolarizing the membrane
10 6. The sudden influx of sodium and depolarization of the membrane creates another electrical impulse that sweeps down the cell membrane deep into the cell by way of the Transverse (T) Tubules.
11 7. The electrical impulse traveling through the T Tubules triggers the release of Calcium from the Sarcoplasmic Reticulum
12 8. This calcium diffuses into the interior of each myofibril and attaches to the Troponin-Tropomyosin Protein Complex located on each Actin (thin) filament
13 9. The Troponin-Tropomyosin complex was blocking the Myosin binding sites on Actin 10. The attachment of Calcium to Troponin-Tropomyosin changes its configuration (shape) and moves it off the Myosin binding sites on Actin allowing the Myosin heads to bind to Actin
14 11. Once the Myosin heads attach they use ATP to "flip" pulling the Actin filaments closer together, shortening the sarcomere Myosin in Action
15 12. The Shortening of the Sarcomere shortens the length of the myofibril, muscle fiber, fascicle, and then the actual muscle itself, pulling on the bone and causing body movement. Muscle Movement
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