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Preparing a SBIR Fast-track Application: The Start-Up Perspective Chris Rogers, PhD.

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Presentation on theme: "Preparing a SBIR Fast-track Application: The Start-Up Perspective Chris Rogers, PhD."— Presentation transcript:

1 Preparing a SBIR Fast-track Application: The Start-Up Perspective Chris Rogers, PhD

2 Mission/Vision  Mission oExemplar Genetics is committed to enabling an improved understanding of life threatening diseases and facilitating the discovery of life changing therapies in an effort to reduce human suffering.  Vision oExemplar Genetics intends to accomplish this mission through the creation and delivery of animal models that represent human disease and to provide the support necessary to study said animals.

3 The Problem  Insufficient Models oAnimal models that faithfully represent human disease are not currently available. This represents an enormous barrier to:  Understanding human disease mechanisms.  Developing novel diagnostics, procedures, devices, prevention strategies and therapeutics.  Predicting the efficacy in humans of new procedures, devices and therapeutics.

4 The Solution  A Better Model oPigs represent a much improved animal model of human disease because:  Pigs and humans share many anatomical, histological, biochemical and physiologic properties.  Pigs and humans are more genetically similar than are mice and humans.  Pigs and humans have similar immune systems and inflammatory responses.  Pigs are excellent models for cardiovascular disease, obesity, diabetes, alcoholism, hypertension, toxicology, intestinal function, nutrition, and injury and repair.

5 Initial Models Cystic Fibrosis  CFTR-null  CFTR-ΔF508 Received a SBIR Fast-track grant from NIH/NHLBI: “Development of a Humanized Porcine Model of Cystic Fibrosis”

6 The Start-Up Perspective Background  The company didn’t exist at time of submission  Two main individuals were involved The science guy (Me) – then, a post-doc  Academic background, research plan experience The business guy – had another job at the time  Academic and business background, business plan experience

7 Tip #1: Start Early! Basic things  Business name, address, phone, email, etc. – Choose wisely! (See Tip #4) Registrations galore  EIN, DUNS, CCR, eRA Commons, etc. I was a one-man Office of Sponsored Research/Grants Management  That took a lot of time…

8 Tip #2: Provide lots of letters Letters of support  Collaborators & Consultants Letters of interest  Potential customers Academic Industry Disease Foundations  Potential investors Investment groups Companies

9 Tip #3: Supplemental Data We submitted new, breakthrough results just before review.  We communicated the importance of the data to our SRO.  It was clear from the reviewers’ comments that this had been vital.  These were the most important two pages of our submission.

10 Tip #4: You’re not done yet We changed our name between the time we submitted the grant and the time we received the award letter.  Big mistake!  Multi-agency nightmare ensued NIH, OLAW, IRS Funds finally available 7 months after award letter! (17 months after submission!)  It’s a good thing we weren’t depending on funding.

11 Summary Start early, there is a lot more to it than the research plan. Provide as many letters as possible. Send in supplemental data. Be patient, a lot can happen before you access your funding.

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