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Ruptured Abdominal Aortic Aneurysms Eliza Long. Treatment of the Ruptured Abdominal Aortic Aneurysm Diagnosis –Clinical –Imaging Resuscitation Surgery.

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Presentation on theme: "Ruptured Abdominal Aortic Aneurysms Eliza Long. Treatment of the Ruptured Abdominal Aortic Aneurysm Diagnosis –Clinical –Imaging Resuscitation Surgery."— Presentation transcript:

1 Ruptured Abdominal Aortic Aneurysms Eliza Long

2 Treatment of the Ruptured Abdominal Aortic Aneurysm Diagnosis –Clinical –Imaging Resuscitation Surgery –Different options Complications

3 Diagnosis Clinical Presentation “Classic triad:” –Severe abdominal pain –Hypotention An episode of syncope may be a hint –Pulsatile mass Large girth may obscure Less common symptoms: –Groin/flank pain, hematuria, groin hernia all secondary to increased intra-abdominal pressure –Congestive Heart Failure with JVD and abdominal bruit if patient has ruptured into the Vena Cava

4 14 x 8 cm abdominal aortic aneurysm arising from the supraceliac aorta and extending to just above the take off of the left renal artery is visualized with extensive thrombus but also extensive flow

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7 –RAAA is misdiagnosed 16% - 30% of the time Common misdiagnosis: –Renal colic, perforated viscous, diverticulitis, gastrointestinal hemorrhage and ischemic bowel –Mortality rates for correctly diagnosed was 58%, and 44% for misdiagnosed Likely due to fact that less severe ruptures have a more subtle presentation and can survive longer before going to OR Diagnosis Clinical Presentation

8 Diagnosis Imaging Plain Films –Enlarged outline of calcified aortic wall A retrospective review showed that 65% of x-rays form RAAA had calcified aortic wall –Loss of psoas shadow Abdominal U/S –Sensitive in detecting aneurysm but not in detecting rupture Abdominal CT –Most accurate method –See presence of retroperitoneal blood (77% sensitive and 100% specific)

9 Enlarged outline of calcified aortic wall Loss of psoas shadow

10 Sensitive in detecting aneurysm but not in detecting rupture

11 See presence of retroperitoneal blood. Here there is not a large retroperitoneal hematoma, but stranding of blood into surrounding tissues

12 Resuscitation If suspecting rAAA: –2 Large bore IVs –Type and Cross for at least 6 Units of pRBCs Confirmed rAAA: –Transfer to Operating room (transfer to center with experienced surgeons prepared for rAAA) –Establish art line and foley –Prep and drape before and during anesthetic induction

13 Resuscitation Actual Pre-Op resuscitation –Controversial Aggressive crystalloid can elevate BP and cause rupture of temporary aortic seal that forms after initial rupture Minimally resuscitate to “maintain conconsciousness” (~80 systolic) and use blood No randomized trials testing the different degrees of resuscitation with rAAA –Animal studies show increased mortality when resuscitation occurs before control of hemorrhage

14 Surgery OPEN TRANSPERITONEAL OPEN RETROPERITONEAL ENDOVASCULAR

15 Surgery Open Repair Hypotension Pararenal Extensive Hematoma Inspect Retroperitoneum Reflect bowel and duodenum Uncontrolled Bleeding Develops Supraceliac Clamp Infrarenal Careful Dissection for Infrarenal Control No Hypotension No Hematoma

16 Surgery Open Repair  TRANSPERITONEAL Transperitoneal allows the fastest and easiest approach for Supraceliac clamp Retract the left lobe of the liver to right to show supraceliac aorta at diaphragm NG tube identifies esophagus and proximal stomach and retracts to the left Enter lesser sac by opening gastrohepatic omentum Aorta is found between crura of diaphragm and is clamped –Can reposition clamp to infrarenal neck of aneurysm once aneurysm is opened –or can make first anastamosis in aneurysm sac and then transfer clamp to graft to reperfuse kidneys and viscera.

17 Retract the left lobe of the liver to right to show supraceliac aorta at diaphragm NG tube identifies esophagus and proximal stomach and retracts to the left Enter lesser sac by opening gastrohepatic omentum

18 Sometimes crura may need to be split with electrocautery for appropriate visualization

19 Aorta is found between crura of diaphragm and is clamped

20 Supraceliac Clamp –Coordinate with anesthesia after clamp “crank up” the resuscitation before releasing supraceliac clamp prepare for hypotension –Advantages quick solution to severe hypotension from intraperitioneal rupture. avoids injury to renal and gonadal vein injury from blind dissection of infrarenal neck –Disadvantage ischemic injury injury to liver, bowel, and kidneys Surgery Open Repair  TRANSPERITONEAL

21 Surgery Open Repair  RETROPERITONEAL ESPECIALLY for pararenal or suprarenal RAAA 10 th interspace incision –1) Left colon mobilized to incise lateral peritoneal attachments. –2) Colon, pancreas, spleen, and kidney are elevated  access diaphragmatic crura. –3) Divide crura  access entire intra-abdominal aorta and visceral and renal vessels –4) May need a thoracoabdominal incision, or extra thoracic incision for the larger people, or the hostile abdomen

22 Surgery Open Repair  Extras Brachial/femoral cut-down for occlusive balloon into aorta Aortic compressor to supraceliac aorta if rapid control needed before establishing exposure for clamp Aortocaval fistula  direct digital pressure above and below the fistula and suture of the fistula from within the sac If iliac aneurysms are present leave alone unless ruptured, if so repair easiest first (allow for pelvic reperfusion) Use cellsaver, its use is justified if anticipate large blood loss

23 Aortic compressor to supraceliac aorta if rapid control needed before establishing exposure for clamp

24 Surgery Open Repair  Anatomic abnormalities Venous anomalies that can cause bleeeding during clamping: –Retroaortic renal vein –Circumaortic renal vein –Left-sided vena cava –Duplicate inferior vena cava Horseshoe kidney –If at neck of aneurysm it prevents adequate exposure (another reason to perform supraceliac clamping) –Isthmus often contains renal tissue, collecting system and blood supply If known before surgery, retroperitoneal approach

25 Surgery Open Repair Closing –25%-30% cases, the abdomen cannot be closed without significant tension from swollen bowel or retroperitoneal hematoma Abdominal compartment syndrome (ACS) is bladder presser > 30cm H2O or 25mm Hg Use early mesh to reduce incidence of multi organ failure from ACS –Especially with pre-op anemia, prolonged shock, pre-op cardiac shock, pre-op cardiac arrest, massive resuscitation, profound hypothermia, or severe acidosis Use nonabsorbable mesh covered with plolyurethane Early mesh closure vs takeback mesh resulted in 6% and 40% colon ischemia respectively

26 Institution requirements: –1) Rapid CT scanning For neck diameter, angulation, and iliac size Only about 20-46% of rAAA are suitable for EVAR –2) Training –3) Devices –4) Suite for Endovascular procedure Surgery Endovascular Repair

27 Stratagies for Repair: –Aorto-unifemoral graft  ipisalateral internal iliac exclusion and a femorofemoral crossover graft (Montefiore group) –Modular aortouniiliac and aortobiiliac Now rupture kits for repair Surgery Endovascular Repair

28 Endovascular Grafts and Other Image-Guided Catheter-Based Adjuncts to Improve the Treatment of Ruptured Aortoiliac AneurysmsTakao Ohki and Frank J. VeithAnn Surg. 2000 October; 232(4): 466–479. Aorto-unifemoral graft

29 Early Experience with the Talent™ Stent-Graft System for Endoluminal Repair of Abdominal Aortic Aneurysms Frank J. Criado, MD, Eric P. Wilson, MD, Eric Wellons, MD, Omran Abul- Khoudoud, MD, and Hari Gnanasekeram, MD Tex Heart Inst J. 2000; 27(2): 128–135. Modular aortouniiliac and aortobiiliac

30 Anesthesia –Can use local (unless patients are squirming) Don’t loose the sympathetic tone that can maintain pressure Some start under local and convert to general for positioning and release of graft Surgery Endovascular Repair

31 Mortality Rates  10% to 45%, but limited numbers of patients Causes  –Colon ischemia –MOF –Continued hemorrage Endoleaks are a much bigger problem in this setting as hemorrhage isn’t controlled Surgery Endovascular Repair

32 Table 102-1. Reported Data on Ruptured Abdominal Aortic Aneurysms (RAAA) Treated by Endovascular Aneurysm Repair FIRST AUTHOR RAAA RE- EVALUATED (no.) EVAR COMPLETED (%) EVAR MORTALITY (%) CONVERSION RATE (%) Ohki, 2001 54 54 251001020 Hinchliffe, 2001 9 9 20854515 Lachat, 2002 55 55 57379.50 Orend, 2002 39 39 21711429 Resch, 2003 94 94 21100190 Scharrer-Pamler, 2003 95 95 2410012.54 Peppelenbosch, 2003 52 52 4065150 Reichart, 2003 23 23 2523170 Totals21971188.5

33 Complications Local Postoperative bleeding related to coagulapathy from hypothermia (12%-14%) Limb ischemia  embolization from aortic debris, or clot formed in illiacs if retrograde flushing is not performed Colonic ischemia (3%-13%) leads to mortality in 73%-100% of time –Degree and duration of hypotension –Patency of IMA –Collateral supply –Site of hematoma Spinal Cord Injury: incidence 2.3%. –Interuption of pelvic blood supply, prolonged aortic cross-clamping, introperative hypotension, aortic embolization, internal iliac interuption

34 Complications Systemic Respiratory Failure  –26-47% (mortality up to 68%) –High O2 requirements, increased lung permeability, decrease in lung compliance –Factors that predispose Large shifts in fluid and blood Pre-existing pulmonary dysfunction Long cross-clamp time Renal Dysfunction  –Incidence is 26-42% in patients in symptomatic aneurysms or rAAA –Higher with suprarenal cross-clamp, longer duration of cross- clamp, pre-existing renal dysfunction, shock, old age

35 Complications Systemic Irreversible Shock  –10-15% of rAAA mortality –Irreversible state in which aortic clamping, aggressive fluid resuscitation, and inotropic support can fail to reverse hypotension Cardiac Complications  –MI – mortality of 19-66% –Arrhythmias – mortality 46% –Cardiac arrest – mortality 81-100% –CHF – mortality of 41% –Common as patients usually have simultaneous cardiac dz

36 Complications Systemic Liver Failure  –Due to hypoxic injury Although the liver is robust; can deal with a large degree of hypoxic injury it still must reabsorb hematoma and the increase in metabolism that is required to do this –Patients usually develop jaundice on day 7 Multisystem Organ Failure  –Incidence of 64% –Most common cause of death after 48 hrs –Also referred to as a systemic inflammatory syndrome

37 Complications Systemic Multisystem Organ Failure  –“Two hit” hypothesis 1) Hemorrhagic shock – first ischemic insult primes the inflammatory response 2) Aortic Clamping – second ischemic insult 3) Resuscitation – first reperfusion insult 4) Aortic unClamping – second reperfusion insult –Animal models support PMNs primed by pre-op hemorrhage, and after operative repair there was further activation with elevations of oxidative burst. –These patients are walking into the hospital with oxidative injury

38 Mortality Between 43% to 70% depending on the study Predictors  –Scoring systems POSSUM – 12 physiologic variables and 6 operative variables for calculated risk Hardman index – Based on age, creatinine, hemoglobin, EKG evidence of ischemia, h/o loss of consciousness Multiple Organ dysfunction score (based on respiratory, renal, hepatic, hematologic, neurologic, and cardiac) –Deaths bimodal »Those that died 48 after repair had sig increases in MODS »Renal failure followed by hepatic failure at Day 10 are at highest risk for mortality

39 Table 102-2. Logistic Regression Model Showing the Interaction of Significant Preoperative and Intraoperative Variables That Predicted Early Survival After Ruptured Abdominal Aortic Aneurysm Repair CREATININE (mg/dL)CLAMP SITEURINE OUTPUT (mL)PROBABILITY OF SURVIVAL (%) ≤1.3Infrarenal≥20090 ≤1.3Infrarenal1-19976 >1.3Infrarenal≥20071 ≤1.3Suprarenal≥20065 ≤1.3Infrarenal052 >1.3Infrarenal1-19946 ≤1.3Suprarenal1-19939 >1.3Suprarenal≥20033 >1.3Infrarenal023 ≤1.3Suprarenal018 >1.3Suprarenal1-19915 >1.3Suprarenal06

40 Logistic Regression Model Showing the Interaction of Significant Postoperative Complications That Predicted Early Survival After Ruptured Abdominal Aortic Aneurysm page 1486 page 1487 Cr, creatinine. Modified from Johnston KW: Ruptured abdominal aortic aneurysm: Six-year follow-up results of a multicenter prospective study. Canadian Society for Vascular Surgery Aneurysm Study Group. J Vasc Surg 19:888, 1994.

41 Conclusions Diagnosis – Have RAAA on the differential, don’t miss the diagnosis Resuscitation – Less is more until aorta is clamped Surgery – Quick, safe exposure. Use a method that you are experienced with. Complications – Expect them

42 I would like to end with one more aorta… mine

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44 If substantial hematoma prevents distal dissection use occlusive balloons placed from inside the aneurysm

45 Surgery Open Repair  TRANSPERITONEAL Hypotention Pararenal Extensive Hematoma Inspect Retroperitoneum Reflect bowel and duodenum Uncontrolled Bleeding Developes Supraceliac Clamp Careful Dissection for Infrarenal Control If no hypotension If no hematoma SupraceliacClamp

46 She was evaluated for an intra-abdominal process because of abdominal pain. The patient was signed out to me by Dr. Lynn at the end of his shift. The patient suddenly called out to the nurse and was noted to be unresponsive. She was breathing shallow. I was called to the bedside. The patient appeared pale to me with pale conjunctivae. She was breathing shallow. Pulse oximetry was 100%. She had a paced rhythm of about 60. Blood pressure was 175/64. Her abdomen was mildly distended but otherwise soft. Because of the patient's shallow breathing and her low cognitive function, I immediately obtained an Accu-Chek, which was 120. I was concerned about anemia, but the hemoglobin was 10. On the other hand, while we were assessing her, I got a call from the radiologist, who reported that the patient had a ruptured AAA. Advance directives did not show any DNR status. The patient was immediately updated to room 5 for resuscitation. Vascular Surgery was called and immediately came down. We were giving the patient oxygen, attempting a central line placement. O negative blood was ordered. The patient, however, was taken immediately up to a waiting operating room by the vascular surgeons. Transfer nurse helped take the patient up. Oxygen was given 100%.


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