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Hepatitis web study Hepatitis web study Boceprevir for Patients with Prior Failure to PEG + RIB PROVIDE Phase 3 Treatment Experienced Vierling JM, et al.

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Presentation on theme: "Hepatitis web study Hepatitis web study Boceprevir for Patients with Prior Failure to PEG + RIB PROVIDE Phase 3 Treatment Experienced Vierling JM, et al."— Presentation transcript:

1 Hepatitis web study Hepatitis web study Boceprevir for Patients with Prior Failure to PEG + RIB PROVIDE Phase 3 Treatment Experienced Vierling JM, et al. J Hepatol. 2013;Dec 19 [Epub ahead of print].

2 Hepatitis web study Source: Vierling JM, et al. J Hepatol. 2013;Dec 19 [Epub ahead of print]. Boceprevir for Patients with Prior Failure to PEG + RIB PROVIDE Study: Features Drug Dosing Boceprevir = 800 mg three times daily Peginterferon alfa-2b = 1.5 µg/kg once weekly Ribavirin = mg/day (based on weight)

3 Hepatitis web study Lead In Boceprevir Source: Vierling JM, et al. J Hepatol. 2013;Dec 19 [Epub ahead of print]. Boceprevir for Patients with Prior Failure to PEG + RIB PROVIDE Study: Treatment Regimens Peginterferon + Ribavirin B44 PR48 36 Boceprevir 0 Week 8 Peginterferon + Ribavirin B44 PR44 44 Patients who enrolled within 2 weeks after ending/completing previous treatment with PR Patients who enrolled ≥ 2 weeks after ending/completing their previous treatment with PR

4 Hepatitis web study Boceprevir for Patients with Prior Failure to PEG + RIB PROVIDE Study: Results PROVIDE: SVR 24 by Prior Response (mITT) Source: Vierling JM, et al. J Hepatol. 2013;Dec 19 [Epub ahead of print]. SVR = Sustained Virologic Response; mITT = modfied intent to treat analysis 106/16420/4957/8527/28

5 Hepatitis web study Source: Vierling JM, et al. J Hepatol. 2013;Dec 19 [Epub ahead of print]. Boceprevir for Patients with Prior Failure to PEG + RIB PROVIDE Study: Conclusions Conclusions: “Re-treatment with boceprevir with peginterferon/ribavirin (BOC/PR) improved SVR rates in all patient subgroups, including those with prior null response.”

6 Hepatitis web study Hepatitis web study This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Online Hepatitis Web Study Funded by a grant from the Centers for Disease Control and Prevention. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Online Hepatitis Web Study Funded by a grant from the Centers for Disease Control and Prevention.


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