2 Isoniazid Isoniazid-induced hepatitis-most common major toxic effect Peripheral neuropathyCNS toxicity-memory loss, psychosis,seizuresFever and skin rashesDrug-induced SLEHematologic abnormalitiesProvocation of pyridoxine deficiency anemiaTinnitusGastrointestinal discomfortKatzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 773
3 Rifampicin Orange urine, sweat and tears Rashes Thrombocytopenia NephritisLight-chain proteinuriaFlu-like sydrome(fever, chills, myalgia, anemia and thrombocytopenia)Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774
4 Ethambutol Retrobulbar neuritis most common serious adverse eventLoss of visual acuity and red-green color blindnessHypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis)Fever and lymphadenopathyKatzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774
6 *Streptomycin Vertigo and hearing loss nausea, vomiting paresthesia of facerashfeverUrticariaangioneurotic edemaeosinophiliaKatzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775
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