Presentation on theme: "Tuberculosis is a disease caused by an infection with the bacteria Mycobacterium tuberculosis."— Presentation transcript:
Tuberculosis is a disease caused by an infection with the bacteria Mycobacterium tuberculosis.
Typical signs of tuberculosis are: Chronic or persistent cough and sputum production. If the disease is at an advanced stage the sputum will contain blood. Fatigue. Lack of appetite. Weight loss. Fever. Night sweats.
Today, treatment involves three or four different kinds of antibiotics given in combination over 6 to 12 months. Multiple medicines are necessary to prevent the emergence of resistance, which would lead to treatment failure. The main cause of treatment failure is non-compliance with what is perceived as a demanding and prolonged programme of therapy.
For positive culture do susceptibilities and report results to Health Department begin taking four medications isoniazid, rifampicin, ethambutol pyrazinamide and streptomycin. The standard "short" course treatment for tuberculosis (TB), is: isoniazid, rifampicin, pyrazinamide, and ethambutol for two months, Then isoniazid and rifampicin alone for a further four months. This regimen may change if tests later show some of these drugs to be ineffective.
Hepatitis Peripheral neuropathy Lupus
Liver function tests Clinical signs of hepatic toxicity Numbness/tingling of extremities
Hepatitis Orange discoloration of secretions Drug interactions Immunologic mediated illness
Liver function tests Clinical signs of hepatic toxicity CBC, platelets, serum creatinine, bilirubin Bleeding abnormalities
Warfarin Digoxin Beta-blockers Ketoconazole Verapamil Quinidine Methadone Phenytoin. n Corticosteroids n Oral Contraceptives n Dapsone n Theophylline n Sulfonylureas n Cyclosporine n Protease Inhibitors
Gout Rash Peripheral neuritis Optic neuritis
Visual acuity Uric acid levels
Liver function tests Clinical signs of hepatic toxicity Uric acid levels