We think you have liked this presentation. If you wish to download it, please recommend it to your friends in any social system. Share buttons are a little bit lower. Thank you!
Presentation is loading. Please wait.
Published byCarter Richards
Modified over 3 years ago
WHAT IS IT ? Bacterial infectionCaused by Mycobacterium tuberculosis (also called tubercle bacillus) Damages a person’s lungs or other parts of the body Fatal if not treated properly
Mycobacterium – Slender, aerobic rodsGram +ve, Acid fast M.tuberculosis – Reservoir- Humans M.bovis –Reservoir – contaminated milk M.Avium intracellulare-opportunistic (AIDS)
TB flourishes in Poverty, Over crowding, Malnutrition DM, CRF Alcoholism Immunosuppression
TRANSMISSION Spreads through the air when aperson with active TB (Inhalation) Coughs Speaks Laughs Sneezes Ingestion
SPREAD OF TB Local Spread Lymphatic spread Haematogenous SpreadNatural passages – Pleurisy, Peritonitis (salpingitis), Laryngitis , Ileocaecal
PATHOGENESIS Breath in infected air and bacilli go to lungs through bronchioles Bacilli infect alveoli Macrophages attack bacteria, but some survive Infected macrophages separate and form tubercles
Hypersensitivity to tubercular antigensCell Mediated immunity Caseating granulomas, Cavitation
Host response to lipids such as Mycosides(cord factor) & glycolipids ( Wax-D) on the bacterial cell wall Type IV Hypersensitivity
Primary cells infectedare MACROPHAGES
ACTIVE INFECTION Unhealthy person Bacilli overwhelm immune systemBacilli break out of tubercles in alveoli and spread through bloodstream
LATENT INFECTION Initial infection controlled by immune systemBacilli remain confined in tubercles for years
DIAGNOSIS Mantoux test Medical history, x-rays, and smears forAFB, Sputum culture, PCR
SYMPTOMS Perpetual Cough Fever Weight loss Night sweatsLoss of appetite Fatigue Swollen glands Pain while breathing
EVOLUTION OF TUBERCLE ( Granuloma)PMN Macrophages Poorly degradable bacilli CD4+ T cells ( IFN, TNF) Epithelioid cells Hard Tubercle Soft Tubercle
GRANULOMA Central caseous necrosis surrounded byepithelioid cells, Langhan’s giant cells, Rim of lymphocytes and fibroblasts.
FATE OF GRANULOMA Cold Abscess Sinus Formation Fibrosis Dystrophic calcification
CLINICAL SPECTRUM Secondary – Previously sensitized personPrimary – previously unexposed, unsensitized person Secondary – Previously sensitized person - Follows primary, - Reactivation of dormant lesion, - Exogenous reinfection ( Large inoculum of virulent bacilli)
Primary tuberculosis GHON’S COMPLEX( Primary complex)Ghon’s Focus- Subpleural focus in the upper part of lower lobe/ lower part of upper lobe Lymphatic component Lymph node component – Hilar & Tracheo-bronchial
Fate of Primary TB Fibrosis, calcification Progressive Pulmonary TBPrimary Miliary TB Secondary TB
Secondary TuberculosisInitially -- small focus (2 cm) of consolidation in the apical pleura Develop a small area of caseation, fibrosis
Fate of secondary TB Heal with fibrosis Fibrocavitary TB Pneumonia Miliary TB
Progressive Pulmonary TBChild, Elderly, Immunocompromised Erosion of blood vessels hemoptysis Erosion into bronchus Empyema, effusion, pleuritis
MILIARY TUBERCULOSIS Miliary = ‘millet seeds’ Spread thro’ lymphatics Lesions- small / microscopic Liver, Spleen, Kidney, Brain, Bonemarrow adrenals, fallopian tubes, epididymis, etc.
Isolated organ TB: Meningitis Renal Osteomyelitis Adrenals SalpingitisPott’s spine Lymphadenitis- Scrofula Intestinal
IMMUNIZATION Bacilli Calmette Guerin ( BCG) [ Attenuated Strains of Bovine type of Bacilli]
Tuberculosis. What Is It? Bacterial infectionBacterial infection Caused by Mycobacterium tuberculosis (also called tubercle bacillus)Caused by Mycobacterium.
Dr.Bharathi Sengodan M.D., RESPIRATORY SYSTEM TUBERCULOSIS.
Pulmonary Tuberculosis BY: MOHAMED HUSSEIN. Cause Caused by Mycobacterium tuberculosis (M. tuberculosis) Gram (+) rod (bacilli). Acid-fast Pulmonary.
The pathogenesis of Tuberculosis. What is TB? These particles, called airborne droplet nuclei. These droplets can remain airborne for minutes to hours.
Pathology of TB: 1 "It is nice to have money and the things that money can buy, but it's important to make sure you haven't lost the things money can't.
1 Tuberculosis: Basics Rick Speare Anton Breinl Centre School of Public Health, Tropical Medicine and Rehabilitation Sciences James Cook University 16.
Lung Pathology TUBERCULOSIS. TUBERCULOSIS Definition: Chronic infective granuloma caused by tubercle bacilli Causative organism: Two types of bacilli.
TUBERCULOSIS. Definition: chronic infective granuloma affecting nearly all body systems but mainly the lungs. Predisposing factors: A) Environmental.
Dr. Maha Arafah – Assistant Professor in Pathology Office phone number: Available office hours for students: 10 till 12 daily Sunday November.
PULMONARY TUBERCULOSIS By Dr. Abdelaty Shawky Assistant professor of pathology 1.
Unit 3 – Overview of TB Disease Botswana National Tuberculosis Programme Manual Training for Medical Officers.
PULMONARY TUBERCULOSIS-1 Dr. WASIF ALI KHAN MD-PATHOLOGY (UNIVERSITY OF BOMBAY) AL MAAREFA COLLEGE.
Tuberculosis is a chronic respiratory tract disease established by Mycobacterium tuberculosis complex infection and represented clinically as primary,
Lung-lect-5&6 Pulmonary Tuberculosis. Epidemiology: Common disease infects more than 3 millions per year around the world and about one third of world’s.
Causative agent: Mycobacterium tuberculosis Morphological and cultural properties: In tissue, tubercle bacilli are thin straight rods measuring.
R ESPIRATORY BLOCK TUBERCULOSIS Dr. Maha Arafah Associate Professor in Pathology Office phone number: Available office hours for students:
CHRONIC INFLAMMATION Dr. Saleem Shaikh. Introduction Chronic inflammation is defined as prolonged process in which tissue destruction and inflammation.
Dr. Meg-angela Christi Amores
INFECTIOUS BACTERIAL AIRBORNE DISEASES PULMONARY TUBERCULOSIS.
Pulmonary Tuberculosis (1) by Lecturer of chest diseases Ainshams university
Tuberculosis is a chronic disease of respiratory system that established due to Mycobacterium tuberculosis complex infection and represented clinically.
Module 2 TB Disease Transmission & Prevention. Pulmonary Tuberculosis Extra -Pulmonary TB an infectious disease caused by a microorganism called Mycobacterium.
PATHOLOGY OF TUBERCULOSIS Dr. Maha Arafah and Prof. Ammar Rikabi Department of Pathology KSU, Riyadh 2015.
PATHOLOGY OF TUBERCULOSIS Dr. Sufia Husain, Dr. Maha Arafah and Dr. Ammar Rikabi Department of Pathology KSU, Riyadh 2014.
Clinical Manifestations of TB Pulmonary disease – Primary disease Occurs soon after the initial infection in areas of high TB transmission, often in children.
PRACTICAL 4 Foundation Block Pathology Dept, KSU.
TUBERCULOSIS (An ancient persistent continuing human companion) Dr. Awadh Al-Anazi.
TUBERCULOSIS in Children Gatmaitan, Raymond Golpeo, Kirsten Hemedes, Marielisse.
GRANULOMATOUS LUNG DISEASE & INTERSTITIAL LUNG DISEASE.
None spore forming Gram Psitive Bacteria Mycobacterium Tuberculosis.
PULMONARY TUBERCULOSIS AISHA M SIDDIQUI. PULMONARY TB FACTS FACTS HISTORY HISTORY DEFINITION DEFINITION EPIDEMIOLOGY EPIDEMIOLOGY PATHOLOGY PATHOLOGY.
By: Haya M. Al-Malaq Clinical pharmacy department KSU.
Mycobacteria Dr Sadia Ikram. Mycobacteria Aerobic, acid-fast bacilli (rods). Neither Gram-positive nor Gram-negative. Stained poorly by Gram stain. Obligate.
Granulomatous Diseases PRACTICAL Foundation Block 2015 Pathology Dept, KSU.
TUBERCULOSIS By Fahad Al Majid, M.D., FRCP. MICROBIOLOGY Organism: Organism: –Mycobacterium tuberculosis –Aerobic –Non-spore forming,non-motile –Rod..:
World’s second commonest cause of death Principal diseases of poverty The emergence of drug resistant organisms threatens to make Tb incurable.
Definition Mycobacterium Tuberculosis Infection of the lungs is referred to as Pulmonary Tuberculosis.
Copyright © 2007, 2004, 2000, Mosby, Inc., an affiliate of Elsevier Inc. All Rights Reserved. Focus on Tuberculosis (Relates to Chapter 28, “Nursing Management:
Adult Medical-Surgical Nursing Respiratory Module: Tuberculosis.
EXTRAPULMONARY TUBERCULOSIS HamidReza Naderi MD Department of Infectious Diseases Mashhad University of Medical Sciences.
TB Presentation for Healthcare Students ARPHS TB Control Programme July 2008.
Leicester Warwick Medical School Mechanisms of Disease CHRONIC (AND GRANULOMATOUS) INFLAMMATION Dr Peter Furness Department of Pathology.
Tuberculosis By Fion Kung. Objective Describe tuberculosis Describe sigh and symptoms of tuberculosis Describe the nursing diagnosis for tuberculosis.
‘A ‘complex’ case’ Dr Draper & Dr Thomas General Medicine Firm 3rd Yr Medical Students: A. Caleyachetty, Z. Rahman, & N. Shah 18/11/03.
PHTHISIOLOGY. Lecture 5 CLINICAL FORMS OF TUBERCULOSIS: Primary tuberculosis Secondary tuberculosis.
Granulomatous diseases Dr Shaesta Naseem
Infectious Diseases. PATHOGENESIS Primary pulmonary complex Section in lung shows Ghon’s Focus small focus, Under the pleura, (1cm) in size with caseation.
Immunology of Tuberculosis Dr. Hend Alotaibi Assistant Professor & Consultant College of Medicine, King Saud University Dermatology Department /KKUH
© 2017 SlidePlayer.com Inc. All rights reserved.