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Chronic Spinal Cord Injury (Lesi Medula Spinalis Khronis) Darwin Amir Bgn Ilmu Penyakit Saraf Fakultas Kedokteran Universitas Andalas.

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Presentation on theme: "Chronic Spinal Cord Injury (Lesi Medula Spinalis Khronis) Darwin Amir Bgn Ilmu Penyakit Saraf Fakultas Kedokteran Universitas Andalas."— Presentation transcript:

1 Chronic Spinal Cord Injury (Lesi Medula Spinalis Khronis) Darwin Amir Bgn Ilmu Penyakit Saraf Fakultas Kedokteran Universitas Andalas

2 The Spinal Cord Cervical spinal erves Thoracic spinal nerves Lumbar spinal nerves Sacral spinal nerves Conus medullaris Cauda equina


4 Ascending Spinal Cord Tract 1 st order neuron - cutaneous receptors of skin and proprioceptors  spinal cord or brain stem 2 nd order neuron - to thalamus or cerebellum 3 rd order neuron - to somatosensory cortex of cerebrum Conducts sensory impulses upward through 3 successive chains of neurons

5 Ascending Spinal Cord Tract

6 The Spinal Cord spinal cord spinal nerve vertebra


8 Cross Section of Spinal Cord White matter: Myelinated axons forming nerve tracts Fissure and sulcus Three columns: ◦Ventral ◦Dorsal ◦Lateral Gray matter: Neuron cell cell bodies, dendrites, axons ‘Horns’: ◦Posterior (dorsal) ◦Anterior (ventral) ◦Lateral Commissures: ◦Gray: Central canal ◦White (see later for white matter pathways)

9 The Nervous System The Spinal Cord-part of the CNS found within the Spinal column The spinal cord communicates with the sense organs and muscles below the level of the head Bell-Magendie Law-the entering dorsal roots carry sensory information and the exiting ventral roots carry motor information to the muscles and Glands Dorsal Root Ganglia-clusters of neurons outside the spinal cord

10 Nerve Pathways into the Spinal Cord sensory pathway motor pathway

11 Somatic Sensory Pathway



14 Symptoms and Signs Must be mastering in mind Start by understanding anatomy and physiology of the Nervous System Don’s forget the of CNS systematically  - Anatomy of CNS  - Physiology of CNS  - Pathophysiology of the Disease  - The steps to make the diagnosis

15 Sensory disturbances ▪ S oft touch, pain, temperature, position, vibration impaired below the level of lesion ▪ Band like radicular pain/segmental paraesthesia at the level of lesion ▪ localised vertebral spine pain- destructive lesions

16 Motor disturbances ▪ Paraplegia/quadriplegia ▪ Acute-flaccid / Areflexic-spinal shock latter-hypertonic / hyper reflexic, loss of superficial reflexes, Babinski +, flexor/extensor spasm ▪ Extension of hip, knee occurs in high spinal & Incomplete lesion

17 Flexion of hip, knee occur in low spinal & complete lesion At the level of lesion – paresis, atrophy, fasciculations,and areflexia(LMN signs) in a segmental distribution because of damage to the anterior horn cells and ventral roots Motor disturbances

18 Autononomic disturbances initially atonic, latter spastic bladder, rectal sphincter disturbances orthostatic hypotension trophic skin changes anhydrosis impaired temperature control vasomotor instability sexual disturbances I/L horner syndrome

19 Causes of Chronic Lesion ° Tumour ° Multiple sclerosis ° Vascular disorders ° Spinal epidural hematoma/abscess ° Auto immune disease ° Herniated intervertebral disc ° Combine degeneration of B 12 Deficiences



22 Complete spinal cord transection (Transverse myelopathy)

23 All acsending tracts from below the level of the lesion and all descending tract from above the level of lesion interrupted. Motor, sensory, autonomic functions below the level of lesion disturbed Causes : ° tumour ° multiple sclerosis ° vascular disorders ° spinal epidural hematoma/ ° spinal epidural abscess ° herniated intervertebral disc ° auto immune disease


25 Central spinal cord lesion Spinal cord damage starts centrally and spreads centrifugally Decussating fibers of spinothalamic tract involved initially Thermo anaesthesia, analgesia in a ”vest like” or “suspended” bilateral distribution with preservation soft touch sensation and proprioception-- - dissociation of sensory loss

26 Central spinal cord lesion Forward extension of disease anterior horn cells involved segmental neurogenic atrophy, paresis, areflexia Lateral extension I/L Horner syndrome Kypho scoliosis Spastic paralysis Dorsal extension I/L Position sense, vibratory loss

27 Central spinal cord lesion Extreme venterolateral extension thermo anaesthesia, analgesia with sacral sparing Neuropathic arthropathy Pain



30 Posterior column disease

31 Tabes dorsalis-tabetic neuro syphilis, progressive locomotor ataxia Impaired vibration and position sense, and decreased tactile localisation Lability of mechanical sensation threshold, tactile & postural hallucinations, persistence of mechano receptor sensation, disturbances in the knowledge of extremity movement and positions (temporal & spatial disturbances) Sensory ataxia in dark, Romberg (+)

32 Ataxic / stomping/ double tapping gait Positive sink sign In tabes dorsalis lancinating pain, urinary incontinence, Negative patellar and ankle DTR, hypotonic limb, hyper extensible joints abdominal, laryngeal crises, impaired light touch perception, Argyll robertson pupil, optic atrophy, ptosis, ophthalmoplegia Posterior column disease

33 ○ Lhermitte sign or barber chair syndrome due to increased mechano sensitivity ○ Truncal and gait ataxia : also seen in mets causing cord compression ○ I mpaired conduction in dorsal spino cere - bellar tract may be a primar manifestation of epidural spinal cord compression-lower extremity dysmetria and gait ataxia. ○ P t usually have thoracic spine compression due to selective vulnerability of spinocere bellar tract in thoracic spine to compres - sive ischemia Posterior column disease


35 Hemisection of the spinal cord ( Brown sequard syndrome)

36 Loss of pain, temp C/L to the hemisection- interruption of crossed spino thalamic tract Loss of proprioception – interruption of ascending fibers of posterior column Spastic weakness due to interruption of descending cortico spinal tract Segmental LMN signs and sensory changes at the level of lesion due to damage of the roots and anterior horn cells at the level of lesion













49 Thank you Brain For all you remember What you forgot was my fault

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