n = 1 : Distinguishable diastereomers n = 2 : not effect on the d 3 -isopropyl 73.5 ee% Still an equilibrium between the two helices
What is the problem ? The sulfoxide controls the first axisThe first urea doesn't control the next one
How to solve it ? Is the R group can drive the equilibrium to only one helix ??? Calculation using Spartan (density functional level) shows a minimum energy for the helicoidal structure First answer :
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