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Understanding Cancer and Related Topics Understanding Nanodevices Developed by: Jennifer Michalowski, M.S. Donna Kerrigan, M.S. Jeanne Kelly Brian Hollen.

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Presentation on theme: "Understanding Cancer and Related Topics Understanding Nanodevices Developed by: Jennifer Michalowski, M.S. Donna Kerrigan, M.S. Jeanne Kelly Brian Hollen."— Presentation transcript:

1 Understanding Cancer and Related Topics Understanding Nanodevices Developed by: Jennifer Michalowski, M.S. Donna Kerrigan, M.S. Jeanne Kelly Brian Hollen Explains nanotechnology and its potential to improve cancer detection, diagnosis, and treatment. Illustrates several nanotechnology tools in development, including nanopores, quantum dots, and dendrimers. These PowerPoint slides are not locked files. You can mix and match slides from different tutorials as you prepare your own lectures. In the Notes section, you will find explanations of the graphics. The art in this tutorial is copyrighted and may not be reused for commercial gain. Please do not remove the NCI logo or the copyright mark from any slide. These tutorials may be copied only if they are distributed free of charge for educational purposes.

2 What Is Nanotechnology? Nanodevices Nanopores Dendrimers Nanotubes Quantum dots Nanoshells Tennis ballA periodWhite blood cell Water molecule

3 Nanotechnology Plays by Different Rules Normal ScaleNanoscale

4 Designing Nanodevices for Use in the Body Too BigToo Small

5 Manufacturing Nanodevices Scattered X-rays Atoms in crystal Detector NanodevicesCrystalWhite blood cell CrystalX-ray beam

6 Nanodevices Are Small Enough to Enter Cells Cell White blood cell Water molecule Nanodevices

7 Nanodevices Can Improve Cancer Detection and Diagnosis ImagingNanotechnologyPhysical Exam, Symptoms

8 Nanodevices Can Improve Sensitivity and determine which cells are cancerous or precancerous. Precancerous cells Normal cells Nanodevices could potentially enter cells Precancerous cells Normal cells

9 Nanodevices Can Preserve Patients’ Samples Cells from patient Cells preserved Active state preserved Cells altered Active state lost Additional tests Cells from patient Nanotechnology Tests Traditional Tests

10 Nanodevices Can Make Cancer Tests Faster and More Efficient Patient APatient B

11 Cantilevers Can Make Cancer Tests Faster and More Efficient Cancer cell Water molecule Nanodevices Cantilevers Antibodies with proteins Antibodies White blood cell Bent cantilever

12 Nanopores A Single- stranded DNA molecule Single-stranded DNA molecule White blood cell Water molecule Nanodevices Nanopores Single-stranded DNA molecule ATCGATCG Nanopore T

13 Nanotubes – Marking Mutations Cancer cell Water molecule Cancer- associated changes are tagged with bulky molecules. Bulky molecule tag Mutation DNA White blood cell Nanodevices Bulky molecule tag

14 Nanotubes – Mapping Mutations A nanotube traces the shape of the DNA and makes a map. Nanotube White blood cell Water molecule Nanodevices Nanotube

15 Quantum Dots Ultraviolet light off White blood cell Water molecule Nanodevices Quantum dots Quantum dots emit light Ultraviolet light on Quantum dots Quantum dot bead

16 Quantum Dots Can Find Cancer Signatures Cancer cells Healthy cells Quantum dot beads Healthy cells Cancer cells

17 Improving Cancer Treatment Nanotechnology TreatmentTraditional Treatment Intact noncancerous cells Noncancerous cells Toxins Nanodevices Cancer cells Dead noncancerous cells Noncancerous cells Drugs Dead cancer cells Dead cancer cells Toxins Cancer cells

18 Nanoshells Nanoshell White blood cell Water molecule Nanodevices Nanoshells Gold Near-infrared light onNear-infrared light off Nanoshell absorbs heat

19 Nanoshells as Cancer Therapy Nanoshells Dead cancer cells Nanoshells Cancer cells Healthy cells Intact healthy cells Near-infrared light Healthy cells Cancer cells

20 Nanodevices as a Link Between Detection, Diagnosis, and Treatment Nanodevice Reporting TargetingDetection Imaging Nanotechnology Cancer Treatment Cancer cell Traditional Cancer Treatment Cancer cell Drug

21 Dendrimers Dendrimer White blood cell Water molecule Nanodevices Dendrimer Cancer cell

22 Dendrimers as Cancer Therapy Cell death monitor Reporter Therapeutic agent Cancer detector Water molecule White blood cell Nanodevices Dendrimer

23 Nanotechnologies in Patient Care Today2020

24 We would like to hear from you... If you have questions about this tutorial’s content, suggestions for new topics, or other feedback on the Web site, please send an to If you have questions about this tutorial’s artwork or want permission to use it, please send an to


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