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Introduction The incidence of prostate cancer in Asians is lower compared to the Westerners in men with PSA <20 ng/ml. These differences could be due to.

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Presentation on theme: "Introduction The incidence of prostate cancer in Asians is lower compared to the Westerners in men with PSA <20 ng/ml. These differences could be due to."— Presentation transcript:

1 Introduction The incidence of prostate cancer in Asians is lower compared to the Westerners in men with PSA <20 ng/ml. These differences could be due to genetic influences or differences in the interaction of various hormones. Scientific evidence for the correlation between hormones, in particular androgens and the risk of prostate cancer have been equivocal. Animal model studies have shown that androgens and oestrogens play a part in mediating tumorigenesis. However, epidemiological studies based on serum samples from healthy and prostate cancer men have failed to demonstrate any clear relationship. Conclusions Serum levels of testosterone, DHT, cortisol and oestradiol may be associated with the development of prostate cancer. These hormones could be used to discriminate prostate cancer from benign causes, especially in Asian men with raised PSA. Results There were no significant difference in PSA levels between BPH (mean PSA= 12.96 ng/ml) and prostate cancer (mean PSA= 12.16 ng/ml) samples (p= 0.87). The serum hormone levels between CaP and BPH were not statistically significant for androstenedione, DHEA, FSH and LH. The following hormones did show statistically significant levels (α { "@context": "http://schema.org", "@type": "ImageObject", "contentUrl": "http://images.slideplayer.com/8/2420315/slides/slide_1.jpg", "name": "Introduction The incidence of prostate cancer in Asians is lower compared to the Westerners in men with PSA <20 ng/ml.", "description": "These differences could be due to genetic influences or differences in the interaction of various hormones. Scientific evidence for the correlation between hormones, in particular androgens and the risk of prostate cancer have been equivocal. Animal model studies have shown that androgens and oestrogens play a part in mediating tumorigenesis. However, epidemiological studies based on serum samples from healthy and prostate cancer men have failed to demonstrate any clear relationship. Conclusions Serum levels of testosterone, DHT, cortisol and oestradiol may be associated with the development of prostate cancer. These hormones could be used to discriminate prostate cancer from benign causes, especially in Asian men with raised PSA. Results There were no significant difference in PSA levels between BPH (mean PSA= 12.96 ng/ml) and prostate cancer (mean PSA= 12.16 ng/ml) samples (p= 0.87). The serum hormone levels between CaP and BPH were not statistically significant for androstenedione, DHEA, FSH and LH. The following hormones did show statistically significant levels (α


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