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BBS3027 2000: Infectious Diseases Dr Garwin Sing

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Presentation on theme: "BBS3027 2000: Infectious Diseases Dr Garwin Sing"— Presentation transcript:

1 BBS : Infectious Diseases Dr Garwin Sing

2 Gut Mucosa

3

4 Mucosal Epithelium

5 Epithelial Barriers to Microbial Infection: Physical Epithelial cells joined by tight junctions Exfoliation of surface cells Mucous flow by ciliated epithelia (respiratory tract)

6 Epithelial Barriers to Microbial Infection: Chemical Enzymes: Lysozyme (tears, saliva, sweat) Pepsin (stomach) pH:Fatty Acids/amino acids (skin) Gastric acids (stomach) Antimicrobial:Transferrin (mucus)

7 Epithelial Barriers to Microbial Infection: Competition Gut Flora

8 Protection from Infectious Agents Innate ImmunityFever, interferon, neutrophils, macrophages, NK cells Adaptive ImmunityB cells, T cells

9 Congenital Infections

10 Viruses Bacteria Fungi Parasites Anatomy Physiology Immunity Commensals

11 Sources of Infection: Exogenous InhalationCommon cold, flu, Legionnaire’s Disease, Coccidioidomycosis IngestionTyphoid fever, tapeworm, cryptosporidium, Hepatitis A STDGonorrhea, HIV WoundTetanus, Rabies Insect BiteMalaria, Yellow Fever, Dengue

12 Sources of Infection: Endogenous Gute.g E coli Skine.g. staphylococcus Tonsils Throat e.g streptococcus Bloode.g. EBV Lungse.g Candida, CMV, streptococcus


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