Presentation on theme: "New Developments In The Management of Prostate Cancer Dr. Manish Patel Urological Cancer Surgeon Westmead Public and Private Hospital Westmead Public and."— Presentation transcript:
New Developments In The Management of Prostate Cancer Dr. Manish Patel Urological Cancer Surgeon Westmead Public and Private Hospital Westmead Public and Private Hospital Sydney Adventist Hospital Senior Lecturer, University of Sydney
New Developments In The Management of Urological Cancers Agenda Prostate Cancer- PSA testing –Controversy on screening. Prostate Cancer- New developments in treatment. –Pros and cons of each treatment.
Prostate Cancer- PSA testing Mr J.B. 51 year old. Mild LUTS Hypertension Asks his G.P. for a test for prostate cancer? What should the G.P discuss with him?
Prostate Cancer- PSA testing Digital Rectal Exam –Important –15% of cancers have abnormal DRE but “normal” PSA PSA –Blood test –Can detect early Cancer
Potential Benefits Prostate Cancer Screening Potential Harms Need to discuss the individual benefits and risks of screening with all male patients 50-70years. PSA screening detects cancers earlier. Treating early CaP does improve survival. Not shown to improve survival yet. False positives are common. It is possible to miss a cancer Indolent cancers are treated inadvertantly
Prostate Cancer- PSA testing PSA Test: 3.0 ng/ml, F/T 9%, Normal DRE Is this normal? AgeMedian PSANormal Range 40-490.7ng/ml0-2.5ng/ml 50-590.9ng/ml0-3.5ng/ml 60-691.2ng/ml0-4.5ng/ml 70+1.4ng/ml0-6.5ng/ml
Prostate Cancer- PSA testing Risk of Prostate Cancer in Men with Normal DRE PSA Levels Risk Of Prostate Cancer 1-1.99 17% 2-2.99 24% 3-3.99 27% 4-10 29% 10+ 45%
Prostate Cancer- PSA testing Prostate Cancer- PSA testing Free to Total (%) Does Help Specificity.
Prostate Cancer- PSA testing PSA Velocity is important to calculate Men with PSA below 4.0ng/ml –PSA velocity > 10%/yr =30% risk CaP –PSA velocity >0.5ng/ml/yr = 45% risk CaP –PSA velocity >2.0ng/ml/yr = high risk of death –More accurate with multiple measures over time.
Prostate Cancer- PSA testing Prostate Biopsy With Local Anaesthetic Block Mr J.B.’s risk of cancer is approx 50%. Chooses to have a prostate biopsy Very well tolerated under local anaesthetic. –Pudendal nerve block.
Prostate Cancer-Options of Treatment Mr J.B. Has Prostate Cancer Biopsy results: Gleason Score 3+3=6 In 2/12 cores involving 25%-50% of the cores. Treatment Decisions Depend On: –Patient’s normal life expectancy –Aggressiveness of cancer –Cure rates of individual treatments –Tolerability of side effects. What Are His Options Of Treatment?
Prostate Cancer-Options of Treatment Active Surveillance Radical Prostatectomy Seed Brachytherapy External Beam Radiotherapy HIFU (High Intensity Focused Ultrasound)
Indolent Cancer A cancer that is small and low grade and unlikely to grow in the man’s lifetime. Incidence of indolent cancers is increasing (>30%). Mr J.B. Could have active surveillance.
Prostate Cancer-Options of Treatment Active Surveillance Treatment for small low grade cancers with low biological potential. Very close monitoring 3 monthly –PSA –DRE –Biopsy at 6 months, 18 months and 2 yearly after. Treat curatively if any sign of cancer growth. Patel et.al J Urol 2004
Pros and Cons of Active Surveillance Pros No major procedure No side effects of treatment Cons Anxiety will lead to treatment in 15% 50% will progress over 10 years Although no side effects not likely to improve overall quality of life.
A Biopsy At 6 Months Is Very Predictive Of Cancer Growth. 2 nd Biopsy -ve Log Rank Test p=0.002 2 nd Biopsy +ve Patel et.al. J Urol. 2004;171(4):1520
Prostate Cancer-Options of Treatment Prostate Cancer-Options of Treatment Radical Prostatectomy
Recovery of Erections after RP By Extent of Preservation of Neurovascular Bundles
Sural Nerve Grafts- For patients Undergoing NVB Resection Undergoes radical prostatectomy with unilateral neurovascular bundle resection Also has sural nerve graft placed
Recovery of Potency for Unilateral Resection with Nerve Graft compared to No Nerve Graft Unilateral nerve graft n=45 No nerve graft n=17 Patel et.al. AUA 2003
Pros and Cons of Surgery Pros Excellent cancer control Evaluate the lymph nodes Accurate prognosis Radiotherapy possible after surgery Cons Recovery 2-3 weeks Major Surgery Possible incontinence Possible impotence
Brachytherapy (seed) Toxicity –Urinary Frequency/Urgency Retention Bleeding –Rectal Same –Impotence L/T same as surgery (bilateral nerve sparing)
Pros and Cons of Brachytherapy Pros Not a major procedure Quick recovery Initially potency preserved Cons Only controls low risk disease L/T outcomes not known thus hesitate in young patients. Won’t know prognosis for 1-2 years L/T impotence same as surgery Significant rectal and urinary side effects. Unable to have surgery after
Prostate Cancer-Options of Treatment Prostate Cancer-Options of Treatment External Beam Radiotherapy DRR Image (AP) Machine Target
External Beam Radiotherapy Toxicity –Urinary Frequency/Urgency Retention/Stricture Bleeding –Rectal Same –Impotence L/T same as surgery (bilateral nerve sparing)
Pros and Cons of Radiotherapy Pros Not major surgery Initially potency preserved Cons 7 weeks treatment Won’t know prognosis for 1-2 years L/T impotence same as surgery Significant rectal and urinary side effects. Unable to have surgery after
Prostate Cancer-Options of Treatment Prostate Cancer-Options of Treatment New Treatments- HIFU Minimally invasive US focused in the prostate causes coagulative necrosis Temporary catheter for 2 weeks. Experimental, but recent results are encouraging.
HIFU Advantages Minimally invasive Relieves obstructive symptoms Early cancer cure appears similar to XRT Treatment is repeatable Possible to have surgery afterwards. 90% potency Disadvantages New technology- L/T results unknown. Expensive Limited to small prostates and Gleason 7 or less.
Mr J.B Chose radical prostatectomy Continent after 2 weeks. Started penile rehabilitiation at 6 weeks Potent at 4 months. PSA recurrence free so far.
Case 2 Mr AB 72 year old HT Coronary stents PSA 15.2ng/ml Rectal exam: large hard right sided nodule.
Case 2 Prostate Biopsy: Gleason 4+4 6/12 cores involved
Following Diagnosis- Need to Be Staged. A CT Scan Will detect metastases to the lymph nodes. A Bones Scan will detect cancer in the bones
Treatment Options Watchful Waiting XRT plus Hormone therapy HDR Brachytherapy plus Hormone Therapy Radical Prostatectomy
Prostate Cancer-Options of Treatment Need Adjuvant Androgen Deprivation Therapy For High Risk Disease. Hot flushes Lethargy Depression/mood swings Weight gain Anaemia Osteoporosis Impotence Muscle loss
Dose of Radiotherapy is very important in Intermediate and high risk cancer.
External Beam Radiotherapy From Liebel and Fuks. MSKCC, 2000
Prostate Cancer-Options of Treatment High Dose Rate Brachytherapy. Increases dose to the prostate locally For high risk disease
HDR Brachytherapy Boost Used for high risk prostate cancers Used in conjunction with hormones and external beam radiotherapy Advantages –Higher radiation dose –Theoretically better cancer result Disadvantages –Much higher urinary side effects –No Long term studies
Pros and Cons Of Prostate Cancer Treatments Cancer Cure Side Effects ProsCons Radical Prostatectomy Highest Cure Rate Cancer removed Lymph nodes treated Salvage XRT Recovery time Incontinence ED Robotic Prostatectomy Lower than open operation. Earlier dischargeWorse incontinence Brachytherapy Only effective in low risk disease Early recovery Severe urinary and rectal SE ED External Beam Radiotherapy Moderate cure rateSame as above HDR Brachytherapy Effective for high risk disease Severe urinary SE ED HIFU Possibly equivalent to XRT. Minimally invasive Multiple treatments Irritative urinay SE
Summary Age specific PSA is Important but PSA velocity and F/T ratio are important when PSAs are low.Age specific PSA is Important but PSA velocity and F/T ratio are important when PSAs are low. –Have a low threshold to refer. Treatment decisions for prostate cancer depend onTreatment decisions for prostate cancer depend on – likely threat of the cancer to life –cure rate achieved by the treatment –side-effect profile.