Genetic Material: DNA vs RNA - compare and contrast.
DNA Structure What is the structure called?
Building blocks of DNA What are the building blocks of DNA? What are the building blocks made of? (3 parts)
How do they fit together?
Try “replicating” this single strand of DNA
What is the significance of the order of the nitrogenous bases?
Protein Synthesis: Step 1: Make a Copy= “Transcription”
Try Transcribing this piece of DNA into mRNA
Why doesn’t the mRNA just stay inside the nucleus?
Step 2: “Reading the code to make the protein = “Translation”
Breaking “THE CODE”: An Analogy: “DNA is like a novel” Nitrogenous bases = “letters” Triplets = “words” A gene = “a sentence” A chromosome = “a chapter”
The Code: How do you follow the mRNA code?
Video on Protein Synthesis (includes tRNA) o&mode=related&search= o&mode=related&search
Try “DECODING” this piece of DNA Code DNATACGGACAGTAAATT mRNA Amino acids DNATACGGACAGTAAATTmRNAAUGCCUGUCAUUUAA Methi- onine leucinevaline isoleuc ine stop
Great video on a cell’s life functions: 0.html 0.html Here is the explanation of what is happening: ml ml Protein Production
Genes -WHAT are they? -WHERE are they? -How many genes do we have? -WHY are we storing the information for PROTEINS???
Enzymes WHAT are they? What do they do? Why do our DNA molecules store the instructions to make them?
One Gene = One Protein? Human genome = approximately 25,000 genes Number of proteins humans make is approximately 90,000. NOT SURE HOW THIS CAN BE!
Deletion Addition Substitution Positive Neutral Negative Mutagens Example: Deletion The result can be a completely non- functional protein…doesn’t make sense. i.e. --- THE CAT ATE THE RAT--- If you delete a base (letter) ‘C’ ---THE ATA TET HER ATH-----
Another example: Original message: THE BIG DOG BIT TED AND RAN OFF ADDITION/FRAMESHIFT THE BIG FDO GBI TTE DAN DRA NOF F--