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Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 Traitement du cancer du sein Incidence croissante.

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Presentation on theme: "Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 Traitement du cancer du sein Incidence croissante."— Presentation transcript:

1 Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 Traitement du cancer du sein Incidence croissante (1/8 des femmes en Amérique du Nord) 4 groupes de souris immunodéficientes, injection cellules cancéreuses (C = témoin, X =capecitabine (Xeloda); T = docetaxel (Taxotere) et V = vinorelbine). Mesure volume total des tumeurs après 3 semaines de traitement

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3 Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 Short Output: Call: aov(formula = vol ~ traitement, data = cancer, na.action = na.exclude) Terms: traitement Residuals Sum of Squares 902.499 4281.987 Deg. of Freedom 3 70 Residual standard error: 7.821205 Estimated effects may be unbalanced Df Sum of Sq Mean Sq F Value Pr(F) traitement 3 902.499 300.8331 4.917884 0.003703385 Residuals 70 4281.987 61.1712

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6 Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 One sample Kolmogorov-Smirnov Test of Composite Normality data: residuals in cancer ks = 0.1083, p-value = 0.0315 alternative hypothesis: True cdf is not the normal distn. with estimated parameters sample estimates: mean of x standard deviation of x 7.201447e-017 7.658809

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8 Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 Call: aov(formula = logvol ~ traitement, data = cancer, na.action = na.exclude) Terms: traitement Residuals Sum of Squares 0.0472497 0.2584280 Deg. of Freedom 3 70 Residual standard error: 0.06076042 Estimated effects may be unbalanced Df Sum of Sq Mean Sq F Value Pr(F) traitement 3 0.0472497 0.01574991 4.266154 0.007965556 Residuals 70 0.2584280 0.00369183

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10 Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 One sample Kolmogorov-Smirnov Test of Composite Normality data: residuals in cancer ks = 0.1269, p-value = 0.0048 alternative hypothesis: True cdf is not the normal distn. with estimated parameters sample estimates: mean of x standard deviation of x 9.376884e-020 0.05949882

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12 Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 Call: aov(formula = absdif ~ traitement, data = cancer, weights = absdif, na.action = na.exclude) Terms: traitement Residuals Sum of Squares 0.0024991 0.1060181 Deg. of Freedom 3 70 Residual standard error: 0.03891715 Estimated effects may be unbalanced Df Sum of Sq Mean Sq F Value Pr(F) traitement 3 0.002499079 0.0008330262 17.21254 1.786746e-008 Residuals 70 0.003387753 0.0000483965

13 Université d’Ottawa - Bio 4518 - Biostatistiques appliquées © Antoine Morin et Scott Findlay 2014-08-25 21:07 Kruskal-Wallis rank sum test data: vol and traitement from data set cancer Kruskal-Wallis chi-square = 11.4984, df = 3, p-value = 0.0093 alternative hypothesis: two.sided

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