The Scripps Research Institute La Jolla, California
The Scripps Research Institute World's largest, private non-profit biomedical research facility Founded in 1961 by Frank Dixon, M.D. 289 Faculty members 815 Postdoctoral fellows 235 Graduate students 1,500 technical and administrative support personnel
The Scripps Research Institute K. C. Nicolaou - Chairman of chemistry dept. Barry K. Sharpless - Nobel laureate Phil S. Baran Dale Boger Carlos F. Barbas III Jin-Quan Yu Albert Eschenmoser Kim D. Jenda Richard Lerner Peter Schultz Julius Rebek Jr. Director, Skaggs Institute for Chemical Biology
BE-43472B Organism inhibited IC 50, M MRSA, ATCC 43300 Methicilin-resistant Straphylococcus aureus 0.15 VRE, ATCC 51299 Vancomycin resistant Enterococcus faecalis 2.0 HCT-116 Human cancer cells 3.3 New structural class among known antimicrobial agents Isolated from marine streptomycete collected in Puerto Rico Chrysophanol dimer linked in tetrahydrofuran rings with an incorporated acetaldehyde molecule Socha, A. M.; Rowley D. C. et al. J. Nat. Prod. 2006, 69, 1070.