Presentation is loading. Please wait.

Presentation is loading. Please wait.

Recent developments in treatment of PD. Drug treatments L-DOPA still the mainstay Other dopamine agonists may prevent side effects.

Similar presentations


Presentation on theme: "Recent developments in treatment of PD. Drug treatments L-DOPA still the mainstay Other dopamine agonists may prevent side effects."— Presentation transcript:

1 Recent developments in treatment of PD

2 Drug treatments L-DOPA still the mainstay Other dopamine agonists may prevent side effects

3 Lesion methods Lesions to subthalamic nucleus can control tremor

4 Deep brain stimulation Pacemaker like device implanted in subthalamic nucleus Reversible lesion

5 Implants of fetal cells 1 st double-blind placebo-controlled surgical trial reported in 2001 (Freed, NEJM). 40 patients, 20 received implants and 20 had placebo procedure PET images showed implants grew Little evidence for improvement after 1 year 15% had dyskinesia that could not be controlled by drugs

6 Whatever happened to J. William Langston? Director of Parkinson’s Institute in Sunnyvale CA. Still studying effects of environmental toxins on PD New findings suggest tobacco and caffeine exert protective effect

7 Whatever happened to the MPTP model? new research reports/year Still the single most important model of PD A few mouse models now exist MPTP model is still most valuable way to test new drugs Eg continuous vs. pulsatile delivery and side- effects (Jenner) Eg continuous vs. pulsatile delivery and side- effects (Jenner)


Download ppt "Recent developments in treatment of PD. Drug treatments L-DOPA still the mainstay Other dopamine agonists may prevent side effects."

Similar presentations


Ads by Google