Presentation on theme: "Back to Basics Practical Pharmacology"— Presentation transcript:
1Back to Basics Practical Pharmacology Dr. Roland Halil, BSc(Hon), BScPharm, ACPR, PharmDAssistant Professor, Dept of Family Medicine, University of OttawaClinical Pharmacist, Bruyere Academic Family Health TeamMarch 2013(Partially adapted from slides by Marc Riachi, R.Ph.)
2ObjectivesReview all pharmacology in an abnormally short amount of time in preparation for LMCCList the four steps of rational prescribingUnderstand the pharmacological classes, generic examples and mechanisms of action of important tools in the practice of medicine.Understand how the kinetics and dynamics of these agents can affect their useHighlight clinical pearls in the proper use of these agents in practice.
3Topics to be covered Antiplatelets and anticoagulants Antibacterials AntimycobacterialsAntifungalsNarcotic analgesicsAutonomic nervous systemAnti seizure drugsMigrainesAntidepressantsAntianxiety agentsAgents for insomniaAntidiabeticsAntilipemicsAntihypertensivesDiureticsNitratesAntiplatelets and anticoagulantsAntiasthmaticsBPHErectile dysfunctionDementiaParkinson’s disease and schizophreniaDyspepsia, GERD and PUDAntiemeticsIBDIBSOsteoporosisGoutOTC drugsAppendix I & IIRef: Marc Riachi, RPh
4Topics to be covered in this lecture AntibacterialsAntimycobacterialsAntifungalsNarcotic analgesicsAutonomic nervous systemAnti seizure drugsMigrainesAntidepressantsAntianxiety agentsAgents for insomniaAntidiabeticsAntilipemicsAntihypertensivesDiureticsNitratesAntiplatelets and anticoagulantsAntiasthmaticsBPHErectile dysfunctionDementiaParkinson’s disease and schizophreniaDyspepsia, GERD and PUDAntiemeticsIBDIBSOsteoporosisGoutOTC drugsAppendix I & II
5A Process for Rational Prescribing (your new best friend) Dr Roland Halil, BSc(Hon), BScPharm, ACPR, PharmDPharmacist, Bruyere Academic FHTAssistant Professor, Dept Family Medicine, U of OttawaMarch 2013
6ObjectivesTo promote an efficient process for selecting optimal drug therapy for patientsTo promote a process for applying population level evidence based medicine to individual patients.
7A Structure Requires Process To prescribe or not to prescribe?That is the question…Rational prescribing requires a process for selecting therapy: (in order)EfficacyToxicityCostConvenience
81. Efficacy – Ask About… Which HARD Outcomes Which SURROGATE Outcomes Mortality benefit?Morbidity benefit?Which SURROGATE OutcomesClinically relevant?THEN “What is the quality of the evidence to prove this?”Meta-analysis?Randomized Controlled Trial?Case series?Anecdotal evidence?
9EfficacyIf there is no efficacy, why waste your time on the potential toxicity, cost and inconvenience of a drug?If there is proven efficacy at the population level, then balance this against the potential toxicity to the individual.
102. Toxicity – Ask About… Age? Newer agents = Less Safety Data BothersomeSevereCommonNot legalRareWho caresAge?Newer agents = Less Safety DataOlder agents = More Safety Data
113. Cost – Ask About… Patient cost vs Societal cost Covered under provincial formulary?Covered under private plans?
124. Convenience – Ask About… What is the likelihood of compliance?Frequency of administration?Daily vs QID?Special restrictions? (eg. bisphosphonates)PO vs IV?Home vs Office vs Hospital therapy?Many interactions?Special monitoring requirements?
13A simple example: Metformin Januvia® VS Why is Metformin first line therapy?Januvia®
15Toxicity Metformin Januvia® ?Unknown - too new Very rare risk of lactic acidosis?0.03 cases / 1000 pt-yrs (~ 50% fatal)Never clearly implicatedGI upset / diarrheaStart low, go slow!B12 / folate deficiency / anemia (6 - 8/100)Reduced absorption – easy to supplementAnorexiausually transientJanuvia®?Unknown - too new?PancreatitisToo few patients examinedGI upsetedema?elevated risk of infection?
16Cost & Convenience Metformin Januvia® Ontario Drug Benefit: $ / tabCovered by ODBRxfiles 2012:~ $33 / 100 daysQD to TID poJanuvia®Ontario Drug Benefit:$ / tabCovered by ODBRxfiles 2012:~ $315 / 100 daysOnce daily po
17Topics to be covered in this lecture AntibacterialsAntimycobacterialsAntifungalsNarcotic analgesicsAutonomic nervous systemAnti seizure drugsMigrainesAntidepressantsAntianxiety agentsAgents for insomniaAntidiabeticsAntilipemicsAntihypertensivesDiureticsNitratesAntiplatelets and anticoagulantsAntiasthmaticsBPHErectile dysfunctionDementiaParkinson’s disease and schizophreniaDyspepsia, GERD and PUDAntiemeticsIBDIBSOsteoporosisGoutOTC drugsAppendix I & II
18Antibiotic Review (80% of the knowledge, 80% of the time) Dr Roland Halil, BSc(Hon), BScPharm, ACPR, PharmDPharmacist, Bruyere Academic FHTAssistant Professor, Dept Family Medicine, U of OttawaMarch 2013
19ObjectivesReview clinically relevant pathogens in human disease in an ambulatory care settingReview antibiotic classes and spectra of activityFocus on bread and butter examples of eachReview treatment recommendations for common infections in primary care
20Process Map the Bugs Map the Drugs Map the Battlefield “Know your enemy”Map the Drugs“Save your ammo”Map the Battlefield
21Part 1 - Map the (Clinically Important) Bugs “Know your enemy” Gram NegativeAerobicβ-Lactamase NegativeCocci (spheres)Gram PositiveBacilli (rods)Anaerobicβ-Lactamase Positive
30β-Lactamase EnzymesFirst penicillinase described in 1940’s even before penicillin was clinically available.Most bugs produce some type of β-lactamase enzyme that destroys β-lactam antibiotics (pen’s, ceph’s, carbapenems)Gm[+] cocci & β-lactamase [-]: only Group A strepgive Penicillin
32Gram Positive Gram Negative Map the BugsAerobesGram Positive Gram NegativeCocci Bacilliβ-L[+] both β-L[+]&[-]AnaerobesBelowdiaphragmB.FragC.Diff3.
33Map the Clinically Important Bugs AerobesGram [+] Gram [-]Cocci BacilliAtypicalsLegionella pneumoniaChlamydia pneumoniaMycoplasma pneumonia3.Anaerobes(esp. Gut organisms)Eg. C-Diff& B-frag4.
341 - Gram [+] Cocci Staphylococcus S. aureus S. epidermidis Methicillin resistant (MRSA)Methicillin sensitive (MSSA)S. epidermidisMethicillin resistant (MRSE)Methicillin sensitive (MSSE)Skin commensalRarely pathogenicStreptococcusGroup A (pyogenes) (β-Lact[-])Group B (agalactiae)Neonates, v. elderly, obstetricsS. pneumoniaetc. etc.Enterococcus(Formerly thought to be ‘Strep D’)E. faecalisE. faecium
352 - Gram [-] Bacilli Easy to Kill Proteus mirabilis Escherichia coli Klebsiella pneumoniaSalmonellaShigellaHaemophilus influenza(Moraxella catarrhalis) (actually a Gm[-] coccus)PEcKSS-HiMHard to KillSerratiaPseudomonasAcinetobacterCitrobacterEnterobacterSPACE bugs
36Gram Negative vs Gram Positive Gm[-]: red on stain. (ie. Don’t retain stain) Gm[+]: blue-purple on stain;Gm[-]: must pass through pores Gm[+]: molecules < 100kDa pass easily.Gm[-]: b-lactamases concentrated in periplasmic space Gm[+]: b-lactamases diffuse outside cell;
37Map the Bugs Summary Atypicals: Anaerobes: Gram positive aerobes: Mycoplasma pneumoChlamydia pneumoLegionella pneumoMap the Bugs SummaryAnaerobes:OralGut – Bfrag & CdiffGram positive aerobes:CocciStaphAureusMRSA (~8-10%)MSSAEpiderimidisMRSE (~65%)MSSEStrepGroup A strep (pyogenes)Group B strep (agalactiae)Strep ViridansStrep pneumo etc.EnterococcusFaecalisFaeciumBacilliListeriaGram negative aerobes:BacilliEasy to KillPEcKSS (Proteus, Ecoli, Klebsiella, Salmonella, Shigella)HiM (H.flu and Moraxella (actually a Gm[-]coccus))Hard to KillSPACE bugs (Serratia, Pseudomonas, Acinetobacter, Citrobacter, Enterobacter)CocciNeisseriagonorrhaeameningitidisMoraxella catarhallis
39Map the Drugs Arms race! Older drugs tend to be simpler drugs Remember: “Bigger guns breed higher walls”Older drugs tend to be simpler drugsMore narrow spectrumBroad spectrum drugs breed resistanceSuperbugs developMRSA, VRE, ESBL, etcOlder drugs have more safety dataTend to be less toxicLearn their historyLearn their pharmacology
40Part 2 - Map the Drugs “Save your Ammo” FluoroquinolonesPenicillinsTetracyclinesAminoglycosidesMacrolidesVancomycinCarbapenemsCephalosporinsClindamycinMetronidazole
41Antibiotics – Mechanisms of Action From: Accessed Dec 28/12
43Beta-Lactams - Cephalosporins 1st GenerationCephalexin (Keflex™)(or Cefadroxil) (po)Cefazolin (Ancef™) (iv)2nd GenerationCefuroxime (po & iv)3rd GenerationCeftriaxone, Cefotaxime, Ceftazidime (iv)Cefixime (Suprax™) (po)4th GenerationCefepime (iv)Increasing Gram[-] coverageCefadroxil (po) 500mg BID or 1g BID – good alternative to KEFLEX 250mg QID or 500mg QID- Same spectrum of activity, only BID, cheap and covered by ODB too.
44Beta-Lactams – Other (FYI) (IV only, inpatient use only) Piperacillin (plus tazobactam)big gun, tazo = suicide substrate, like clavulanic acidCarbapenemsMeropenemImipenemErtapenemMonobactamsAztreonamBroad spectrum, big gun antibiotics that cover Gm[+], both easy and hard to kill Gm[-] bugs, even some anaerobes.
45Antibiotics – Mechanisms of Action From: Accessed Dec 28/12
46Fluoroquinolones 2nd generation 3rd generation 4th generation OfloxacinCiprofloxacinNorfloxacin3rd generationLevofloxacin4th generationMoxifloxacinCovers: strep & Gm[-]’sPEcKSS-HiM & SPACE bugsOfloxacinCiprofloxacinAnti-pseudomonal – the only PO option!NorfloxacinSame spectrum as Cipro (even anti-Pseudomonal) – but only for cystitis UTI.Concentrates in the G.U. system onlyN.B. Not good enough for pyelonephritis or systemic infection
47Fluoroquinolones The “Respiratory FQs” Levofloxacin Moxifloxacin Concentrate in alveolar macrophagesGreater than serum concnLevofloxacinthe more active L-enantiomer of OfloxacinRenal clearanceMoxifloxacinHepatic clearanceEnhanced coverage of:Strep pneumoOral AnaerobesAtypicalsN.B. only Moxi cover B.fragNeither covers C.diff(Both will cover Clostrium non-difficile strains)Both have 100% oral bioavailabilityTherefore PO = IV dose
48Antibiotics – Mechanisms of Action From: Accessed Dec 28/12
49Macrolides Coverage of: Clarithromycin Azithromycin Erythromycin Atypicals, Strep pneumo, & Hi.M. (Hflu & Mcat)So, good for respiratory infections!N.B. But doesn’t cover PEcKSS or SPACE bugsErythromycinEfficacy: Poorer coverage of H.flu, MSSAToxicity:Prokinetic – diarrhea!Worse for QTc prolongationConvenience: QID dosingClarithromycinBetter Hflu &MSSA coverageLess QTc prolongation vs EShorter half-life vs AzithroBID dosing x 7-10daysNew daily ‘XL’ formulationAzithromycinAn azalide, (not a macrolide)Same spectrum of activityLess QTc prolongation vs E & C!Long t1/2 – QD dosing x 5dBUT can breed resistant S.pneumo (since below [MIC] for long periods of time)
50Antibiotics – Mechanisms of Action From: Accessed Dec 28/12
51Aminoglycosides Gentamicin Tobramycin Amikacin Reserved for Pseudomonas aeruginosaAmikacinAll excellent Gram[-] coverage:PEcKSS-HiM and SPACE bugsEfficacy: excellent Gm[-]Toxicity:NephrotoxicityOtotoxicityLess now with daily dosingCost:Cheap, old medsConvenienceNow Once daily IV/IM
52Pharmacodynamics Relationship between Abx Concentration & Effect Concentration Dependent KillingHigher the peak, better the killi.e. Ratio of peak drug concentration and M.I.C. determines rate of kill.Eg. FQs, AGsTime Dependent KillingTime over MIC mattersi.e. Independent of peak concentration. Determined by length of time over MICEg. B-lactams (Pen, Ceph etc)Log [Conc]PeakLog [Conc]MICMICTime (h)Time (h)
53Pharmacodynamics Relationship between Abx Concentration & Effect Concentration Dependent KillingHigher the peak, better the killi.e. Ratio of peak drug concentration and M.I.C. determines rate of kill.Eg. FQs, AGsWith renal impairment:Maintain the peak, lengthen the intervalThis ensures good rate of killing while allowing enough time to eliminate the drug and avoid toxicitiesFor eg:If CrCL = 90mL/min - Levofloxacin 750mg q24h poIf CrCL = 30mL/min – Levofloxacin 750mg q48h poPeakPeakLog [Conc]Log [Conc]MICMICTime (h)Time (h)
54Pharmacodymamics Bactericidal vs Bacteriostatic Bactericidal AbxB-lactams (Pen, Ceph)Aminoglycosides (AGs)Fluoroquinolones (FQs)RifampinMetronidazoleVancomycinBacteriostatic AbxTetracyclinesMacrolidesClindamycinChloramphenicolRarely a clinically important characteristic, unless the patient is immunocompromised or the risk of death with delayed/incorrect therapy is high.
55Combination Therapy Why? Broaden spectrum (eg. Mixed infection)Synergistic activity for hard to kill bugs(eg. Enterococcus or pseudomonas)Prevent resistance(eg. TB)Reduce dose and side effects
56Map the Drugs Pharmacology Summary Many antibiotic classesBeta-lactams generally safest agents.Even at high dosesSome have overlapping mechanisms of actionAvoid combining similar mechanisms of actionCompeting effects may reduce effectiveness of one agentEg. Penicillins + vancomycin – cell wall synthesis inhibitorsEg. Tetracyclines + aminoglycosides –protein synthesis inhibitors via 30-S subunit of the ribosome
59Map the Battlefield Rational Prescribing IndividualEfficacyCould be reduced, BUT:Empiric tx still effective if it is well chosen(Lower risk infections, properly dosed, clinically stable, true indication etc.)ToxicityReduced with narrow spectrum txCostReduced with older txConvenienceUsually less convenientPopulationEfficacyMaintained long term with lower resistance ratesToxicityReduced since lifespan of older drugs is maintainedCostReduced insurance costs, economic losses, hospital costs dealing with superbugsConvenienceVS.
61Map the BattlefieldOtitis media: S.pneumo, Hi,M (Amox +/- Clav, Cef2, Septra)Conjunctivitis: viral – no txSinusitis: viral – no txAECOPD: S.pneumo, Hi,M (Amox +/- Clav, Cef2, Septra)Oral anaerobes: abscess drainage – no tx(Amox 2g – pre dental sx?)C.A.P: S.pneumo, atypicals – (Amox, Macrolides (Clarithro/Azithro))CAP+comorb./risk factors, or NHAP: also HiM bugs (Combine AmoxClav or Cef2 + Macrolide (or use FQ))Pharyngitis: viral – no tx(Group A Strep – Pen VK)Bronchitis: viral – no txSkin abscess: drainage – no txCellulitis: MSSA, S.pneumo – (Clox, Cef1, Clinda)H.pylori: triple po tx PPI + (Clarithro +/- Amox +/- Metro)Pyelonephritis: PEcK – (Septra, Amox/Clav, FQ (not Norflox)UTI (Cystitis): PEcK – (Septra, Macrobid, Amox, Norflox)Cdiff / Bfrag: Metro / po VancoTraveller’s Diarrhea: (80% bacterial): EcSS, (camphlyobacter) - Septra, FQ, (Azithro)
62(Group A Strep, oral anaerobes, Neisseria) Map the BattlefieldPenicillin(Group A Strep, oral anaerobes, Neisseria)Amoxicillin / Ampicillin Cloxacillin(Strep & Enterococcus plus (Staph aureus, Staph epi)Easy-to-Kill Gm[-](ie. PEcKSS))Amox/Clav (Vancomycin)(for Strep & Entero & PEcKSS-HiM) (for MRSA / MRSE)(H.flu & Moraxella can be ~35% amox resistant) (~8-10% / ~ 65% resistant)
63Beta-Lactams - Cephalosporins MSSA and Strep & PEcKSS(same as Amox)N.B. never Enterococcus!1st GenerationCephalexin (Keflex™) or Cefadroxil (po)Cefazolin (Ancef™) (iv)2nd GenerationCefuroxime (po & iv)3rd GenerationCeftriaxone, Cefotaxime, Ceftazidime (iv)Cefixime (Suprax™) (po)4th GenerationCefipime (iv)To boost: for PEcKSS-HiM(same as Amox/Clav)Increasing Gram[-] coverageSPACE bugs: The Big GunsCefadroxil (po) 500mg BID or 1g BID – good alternative to KEFLEX 250mg QID or 500mg QID- Same spectrum of activity, only BID, cheap and covered by ODB too.
64SPACE bugs The Big Guns: 3rd and 4th generation Cephalosporins Carbapenems (Meropenem)Piperacillin/TazobactamAminoglycosides (Gentamicin, Tobramicin)Fluoroquinolones (Levofloxacin, Moxi, Cipro)
65Reserved for Pseudomonas Ciprofloxacin (FQ)The only PO agent!(Use Norfloxacin for UTI if a FQ is needed)Ceftazidime (Cef3)Cefipime (Cef4)Tobramycin (AG)Piperacillin/TazobactamMeropenem
66Need for Bigger gunsThere is a higher risk of Gram negative SPACE bugs with:More risk factors / comorbiditiesCOPD, HIV, Diabetes, CKD etcMore institutionalized settingsCommunity Retirement Home Nursing Home Hospital ward ICU ventilated pt in ICU.
67Map the Battlefield PEN – for Group A Strep, oral anaerobes, Neisseria ?What to do for Strep/Entero?Amox po / Amp iv (also good for PEcKSS)How to boost? Amox/clav (for HiM-PEcKSS)?What to do for Staph?Clox (MSSA, MSSE); Else Vanco (MRSA, MRSE)What about Cef1? (cephalexin / cefadroxil po or cefazolin iv)Maps to Amox/Amp for PEcKSS and strepN.B. NOT Enterococcus (Cef’s never cover enterococcus!)How to boost? Cef2 (cefuroxime) for HiM-PEcKSSWhat about SPACE bugs?FQs, AGs, Cef3, Cef4, Pip/Tazo, Meropenem)Reserved for Ps aureginosa:(cipro, tobra, ceftazidime, cefipime, pip/tazo, meropenem)What about gut anaerobes? (Metro/PO Vanco)What about atypicals? (Macrolides, Tetracyclines (doxy))Where does Septra fit? (with Amox/Clav and Cef2)
68Antibiotics contraindicated in pregnancy (category X) Tetracyclines (also in children < 9 y.o.): are incorporated into fetal skeleton/unerupted teethFluoroquinolonesErythromycin estolate (may cause toxic liver reaction), clarithromycinTMP: in 1st trimester because it is a folate antagonistSulfonamides: last trimester or if delivery is imminent because they interfere with the bile conjugating mechanism of the neonate and may displace bilirubin bound to albumin which may lead to jaundice and kernicterusNitrofurantoin (during labor and delivery only): can affect glutathione reductase activity and hence can cause hemolytic anemia (analogous to the problems it causes in patients with glucose-6-phosphate dehydrogenase deficiency) and hemolytic crises have been documented in newborns and fetusesAminoglycosides: nephrotoxic and ototoxic to the fetusHigh (>2 grams) single dose metronidazoleChloramphenicol (at term or during labour): limited glucuronidating capacity of the newborn’s liverRef: Marc Riachi, RPh
69Antibiotics Preferred in Pregnancy PenicillinsIncluding those in combination with ß-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam)CephalosporinsErythromycin baseAzithromycinClindamycinMetronidazole(regular dose mg BID)Ref: Marc Riachi, RPh
70Summary This is far from an exhaustive review Some parts have been highly simplified for use in clinical practiceSome memorization is needed with regular review of the material to retain this knowledgeDoing so will allow you to choose empiric antibiotics with greater comfort in difficult situations and unfamiliar settings.
72Adapted from: Marc Riachi, RPh TB drugsAdapted from: Marc Riachi, RPh
73Mycobaterium tuberculosis The Consumption Mostly latent, asymptomatic infection (90-95%)Activation risk ~ 10%Usually pulmonary; can occur anywhereSpreads via air dropletOne third of world population infected!Europe:, TB rates rose from 1600s to peak in the 1800s (caused ~25% of all deaths)Organism has "waxy" hard to penetrate cell wallAcid-fast bacilliCombinations of drugs needed to treatSlow growingTherefore requires extended treatment periodTreatment:Multiple side effects = reduced compliance by patient = further emergence of resistant strainsMDR, XDR strainsAdapted from: Marc Riachi, RPh
74Available antimycobacterials First-line:Isoniazid (INH)Rifampin (RIF) or Rifampicin (RMP)Pyrazinamide (PZA)Ethambutol (ETB)Second-line:AmikacinFQs (Ciprofloxacin / Levofloxacin / Moxifloxacin)Clarithromycin / AzithromycinRef: Marc Riachi, RPh
75Treatment - Active Pulmonary TB “4 drugs x 2 months, then 2 drugs x 4 mo”(N.B. 2x/weekly dosing must be D.O.T.)Ref: PHAC. Canadian Tuberuclosis Standards, 6th Ed p Access March 14, 2013.
76Treatment – Latent TB RIF – GI toxicities, major drug interactions! INH – monitor LFTsHepatitis (rare < 20y.o.; >2% in >50y.o.)Drug interactions!RIF – GI toxicities, major drug interactions!Huge inducer of cytochrome P450Ref: PHAC. Canadian Tuberuclosis Standards, 6th Ed p Access March 14, 2013.
77Which agents to use in active disease? Pulmonary or extrapulmonary disease:INH+RIF+PZA+ETBIf resistant to INH:RIF+PZA+ETB (+FQ if severe)If resistant to RIF:INH+PZA+ETB+FQif resistant to INH and RIF:PZA+ETB+FQ+amikacinIf resistant to INH, RIF and PZA or ETBETB (or PZA)+FQ+amikacin+two 2nd line agentsRef: Marc Riachi, RPh
78Adapted from: Marc Riachi, RPh Anti-fungalsAdapted from: Marc Riachi, RPh
79Drug info PZA (may inhibit mycobacterial metabolism): INH (inhibits formation of fatty acids found in the cell wall):Bactericidal; penetrates cavitationsHepatotoxicity (↑ with alcohol & rifampin) monitor LFTsperipheral neuropathy (give vit B6)GI symptoms, skin rash↑ phenytoin, carbamazepine & benzodiazepine blood levelsRIF (inhibits mRNA synthesis):Hepatotoxicity (↑ with alcohol) monitor LFTsPancytopeniaColours urine, feces, saliva, tears orange may permanently stain contact lensesInduces CYP450PZA (may inhibit mycobacterial metabolism):Bactericidal in acid environment (in macrophages)Hepatotoxicity (↑ with alcohol & rifampin) monitor LFTsHyperuricemia monitor uric acidGI symptoms and arthralgiasETB (may inhibit cell wall synthesis):BacteriostaticGI symptoms, hyperuricemiaOcular toxicity and change in color perception monitor at high dosesRef: Marc Riachi, RPh
80Antifungals Oral Topical Injectables Azole anti-fungals Itra- (Sporanox),flu- (Diflucan),vori-,posa-ketoconazole (Nizoral)active vs. yeast and dermatophytesTerbinafine (Lamisil)Nystatinactive vs. yeast onlyTopicalCiclopirox(cream, lacquer, shampoo),nystatin(cream, pv, oral suspension),clotrimazole(cream, pv),miconazoleketoconazole(cream shampoo),terbinafine(cream, spray),tolnaftate(powder suitable for skin folds)Injectablesusually require I.D. consultRef: Marc Riachi, RPh
81Which agents to use? Onychomycosis: Fungal skin: oral terbinafine, oral itraconazole, ciclopirox lacquer (use lacquer only for mild distal form; expensive)Fungal skin:topical clotrimazole, topical miconazole, topical terbinafine, topical ketoconazole. Nystatin is ineffective vs. dermatophytes. Candidal skin infections respond to nystatin. Use topical azoles for tinea versicolor (not terbinafine).Seborrheic dermatitis:topical ciclopirox, ketoconazoleOral candidiasis:Oral nystatin swish and swallow (not absorbed from GI tract). Oral fluconazole.Vulvovaginal candidiasis:topical azoles, po fluconazole one dose (now available without a prescription), boric acid pv suppositories (very irritative)Diaper rash:Topical nystatin, clotrimazole, miconazole, or ketoconazole.Ref: Marc Riachi, RPh
82Drug info Terbinafine po: Very active vs dermatophytes headache, GI diarrhea, dyspepsia, abdominal paintaste disturbance (may persist post treatment)CYP2D6 inhibitor:Decreases formation of active metabolites of tamoxifenMay ↓ breakdown of TCA’s, fluoxetine, paroxetine, fluvoxamine, sertraline, tamsulosin, mirtazapine, haloperidol, some beta blockersAzole antifungals po:Itraconazole and ketoconazole particularly are strong inhibitors of CYP3A4 and so many drug interactions. Also hepatotoxic. Ketoconazole > itraconazole > terbinafine wrt hepatic toxicity. Itra may worsen heart failure symptoms. Ketoconazole is rarely used and is poorly tolerated; anorexia, nausea, vomiting high doses, and effects sexual function/sex hormones and steroidogenesis.Fluconazole is considered a moderate inhibitor of CYP3A4 and so less clinically important drug interactions. Strong CYP2C9, 2C19 inhibitor. QT prolongation with amiodarone, clarithromycin, TCA’s. Bioavailability of PO similar to IV; use PO if possible.Ref: Marc Riachi, RPh
83Hypertension and BP Meds (The ABCD’s of HTN) Dr Roland Halil, BSc(Hon), BScPharm, ACPR, PharmDPharmacist, Bruyere Academic FHTAssistant Professor, Dept Family Medicine, U of OttawaMarch 2013
84ObjectivesList first line classes of medication for the treatment of essential hypertensionExplain how co-morbid indications may change your choice in therapyApply a rational approach in selecting therapyUnderstand the dosing, monitoring and titration of key examples from each class of medication
85Rational PrescribingRational prescribing requires a process for selecting therapy: (in order)EfficacyToxicityCostConvenience
86Reduced sympathetic outflow, and heart rate BCDARBACEinhB-blockersCCB(DHP-type)Diuretics(Thiazide type)Angiotension Receptor BlockerAngiotensin Converting Enzyme InhibitorBeta-BlockerCalcium Channel Blocker (dihydropyridine type)-sartan-pril-olol-dipineLosartanValsartanCandesartanEtcRamiprilEnalaprilPerindoprilBisoprololMetoprololAtenololAmlodipineNifedipineFelodipineChlorthalidoneHydrochlorothiazideIndapamideBlocks conversion of AT1 to ATII (ACEinh) or blocks ATII receptors (ARB) =Inhibition of vasoconstriction, aldosterone, catecholamine, and arginine vasopressin release, water intake, and hypertrophic responsesReduced sympathetic outflow, and heart rate(b1 receptor – in heart)(cardioselective ~ A-M)(b2 receptor – in lungs)(Non-selective ~ N-Z)(“one heart; two lungs”)Relaxation of coronary & peripheral arterial smooth muscle(not AV node!)Inhibits Na+ & Cl- reabsorption in the cortical-diluting segment of the ascending loop of Henle= diuresis.Reduction in systemic vascular resistanceEfficacy: 1st line1st line1st line (< 65y.o.)
87Toxicity: A B C D Hypotension HyperK+ Acute renal failure (ARF) AngioedemaMonitor: SCr, K+, BPBradycardiaBronchoconstriction (in brittle asthmatics with non-cardioselective bbl’s)Monitor: BP, HR, RREdemaOrthostatic hypotensionHypoNa+HypoK+ARFMonitor: SCr, lytes, BPCost:Generic - $$$ODB coveredGeneric - $$Generic: $$$Convenience:QDLosartan25mg to 100mgRamipril2.5mg to 10mgBisoprolol 2.5mg to 10mgAmlodipine 2.5mg to 10mgQAMChlorthalidone 25mg
88Choosing TherapyIf efficacy (#1), cost (#3) and convenience (#4) are all more or less equivalent:Choose based on potential Toxicities (#2)Tailor the meds to the individual patient!Evidence of efficacy is population basedToxicities are individual.Some combos are additive others synergistic BP loweringRarely clinically relevantCan choose between groups A or B plus C or D (synergistic)N.B. Choice will also be guided by various comorbidites
89Comorbidities ARB ACEinh B C D Indication HTN (ALLHAT) MI (HOPE trial) (ALLHAT)MI(HOPE trial)(VALIANT)(CAPRICORN, BHAT)CHF(CONSENSUS, SOLVD, ATLAS)(MERIT-HF, CIBIS II, COPERNICUS)DM2(HOPE)(IDNT, IRMA-2, RENAAL)CVA(HOPE, PROGRESS)(LIFE, SCOPE, MOSES)(ALLHAT, PROGRESS)PVDAfib(Diltiazem)
90Second Line TherapyWhat if you have used all available 1st line options?2nd line options:Alpha blockersSpironolactoneHydralazineNitratesClonidineBeta-blockers (> 65 y.o.)etc.~ Equivalent efficacy – choose based on potential toxicity, cost or convenience factors.Ensure that you balance these factors in their order of importance.
91Second Line Therapy Alpha blockers Spironolactone Hydralazine Nitrates Eg. Terazosin, Prazosin, DoxazosinToxicity: Risk of orthostatic hypotensionCost: cheap, genericConvenience: only QDGood 1st choice of 2nd line txDual treatment of BPH & BP if also needed in male patientsSpironolactoneEfficacy: mortality benefit in late stage CHF (NYHA class III or IV)Toxicity: risk of hyperK+esp with ARBs or ACEinh’sCost: cheap genericHydralazineMOA: direct vasodilation of arteriesToxicity: orthostatic hypotensionCost: cheap, genericConvenience: QID dosingNitrateseg. ISDN, ISMN, NTGMOA: smooth muscle vasodilation of vasculature (veins > arteries);Toxicity: headache, orthostatic hypotension, dizzinessCost: cheap/ genericConvenience: BID- QID dosing;
92Process Start first drug Increase to moderate dose Monitor for efficacy (BP) and toxicityIf close to target:increase doseIf far from target:start new drugDose response curvesFlatten at top halfLess bang for your buckBPmg