Why Choose Organoboron Compounds Advantage of Organoboronic acids: Tolerate wide range of function groups Commercially available Thermal stable, inert to oxygen and water Can be crystallized from water or alcohols Reaction can be carried out under aqueous conditions Nontoxic by-product
Reaction Conditions Pd(PPh 3 ) 4 or PdCl 2 ( PPh 3 ) 2 with aq. Na 2 CO 3 in DME Palladium catalysts with or without a phosphine ligand Some other bases: Et 3 N, NaHCO 3, CsCO 3,TlCO 3, K 3 PO 4, have been used Homogenous or heterogeneous conditions e.g. K 2 CO 3 suspended in toluene
Observation Transition Temperature Compounds Observed Transition temperature ( 0 C) R=C 6 H 13 Cr 111 Col 126 I R=C 8 H 17 Cr 85 Col 104 I R=C 10 H 21 Cr 74 Col 103 I R=C 12 H 25 Cr 47 Col 101 I
Conclusion Suzuki coupling reaction represents one of most straightforward methods of carbon-carbon bond formation The reaction proceeds under mild conditions unaffected by the presence of water,air broad range of functionality yield nontoxic by-products It has been widely applied in academic and industrial lab.