Presentation on theme: "James B. Brewer, Zuo Zhao, John E. Desmond, Gary H. Glover, John D. E. Gabrieli M AKING M EMORIES : B RAIN A CTIVITY THAT P REDICTS H OW W ELL V ISUAL."— Presentation transcript:
James B. Brewer, Zuo Zhao, John E. Desmond, Gary H. Glover, John D. E. Gabrieli M AKING M EMORIES : B RAIN A CTIVITY THAT P REDICTS H OW W ELL V ISUAL E XPERIENCE W ILL B E R EMEMBERED Presented by: David Wu
B ACKGROUND I NFORMATION Most important regions for declarative memory: parahippocampal cortex and some regions of frontal cortex Traditionally fMRI studies used block designs with novel versus repeated scenes to determine which brain areas encode declarative memory Confounds: could be a response to novelty and not encoding, or could reflect habituation, reduced attention or strategic differences because activation is averaged over long predictable blocks This study attempts to resolve these confound by using a event-related design, where separate activations are recorded for each stimulus
D ESIGN 6 right-handed subjects (3F, 3M, aged 22-32) 4 fMRI scans consisting of 24 pictures of indoor and outdoor scenes 30 minutes later, given an unexpected memory test which consisted of all the previously seen pictures and 32 new pictures Judge whether each picture was clearly remembered, familiar, or forgotten
R ESULTS 7 regions where activity level predicted whether pictures would be remembered, familiar or forgotten 1 was in the right inferior frontal sulcal region of the dorsolateral prefrontal cortex 6 were in bilateral parahippocampal cortex Activations greater for remembered compared with familiar (t(5)=3.55, P<0.05) And for familiar than forgotten (t(5)=4.56, P<0.01)
R ESULTS Displays voxels with significant positive correlations between event- related activations to pictures and subsequent memory for those pictures. Right dorsolateral prefrontal cortex (upper right slice 1) Bilateral parahippocampal cortex (all other regions)
R ESULTS Examples of average signal intensity in each region Graph D shows mean voxel response in parahippocampal areas showing significant correlation with subsequent memory in each subject
D ISCUSSION The activated prefrontal area is related to spatial working memory tasks Memory for scenes determined by spatial working memory processes in the right prefrontal area, and long-term memory processes in the bilateral parahippocampal areas Has been proposed two regions constitute a neural circuit that mediates the formation of spatial long-term memories
M Y O PINION Strengths: Simple and effective design that produced unambiguous results Concise paper that was very easy to read Limitations Did not image the entire brain, there could be other activation areas that were not found Small sample size Future Direction: Do different areas predict how well you will remember words, objects or faces?
B IBLIOGRAPHY Brewer J. B., Zhao Z., Desmond J. E., Glover G. H., Gabrieli J. D. E. (1998). Making Memories: Brain Activity that Predicts How Well Visual Experience Will Be Remembered. Science, 281(5380): 1185-1187
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