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Janeway’s Immunobiology Seventh Edition Janeway’s Immunobiology Seventh Edition Chapter 10 Dynamics of Adaptive Immunity Chapter 10 Dynamics of Adaptive.

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Presentation on theme: "Janeway’s Immunobiology Seventh Edition Janeway’s Immunobiology Seventh Edition Chapter 10 Dynamics of Adaptive Immunity Chapter 10 Dynamics of Adaptive."— Presentation transcript:

1 Janeway’s Immunobiology Seventh Edition Janeway’s Immunobiology Seventh Edition Chapter 10 Dynamics of Adaptive Immunity Chapter 10 Dynamics of Adaptive Immunity Steffen Thiel

2 ca.1 uge

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9 DC CD4 T cell T H 1 T H 2 T H 17 Treg

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15 Inhibition af andre CD4 T celler

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17 Parasit infektion T H 1 response T H 2 response

18 Nye adhesionsmolekyler Nye muligheder Effect T Effect T TNF-  VCAM/ICAM Effect T Macro phag

19 Movie – lymphocyte migration

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21 Ingen IL-12 Ingen egne T celler - men IL-12 IL-12 holder gang i T H 1 celler

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23 Memory

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28 Memory T-cells

29 Hvordan ser overfladen af en memory T cell ud

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32 Ingen CD4 T cellsIngen memory Godt CD8 T celle respons

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35 Published online 26 September 2007 | Nature 449, 390 (2007) HIV vaccine failure prompts Merck to halt trial The Thai-trial – publiceret oktober 2009: Hvad pressen og producenterne skrev: "Although the level of protection was modest, we think the study is a major scientific advance,“ said Colonel Jerome Kim, HIV vaccines product manager for the U.S. Army. The controversial $105 million trial, the largest and most expensive AIDS vaccine study ever conducted, took 6 years and involved more than 16,000 volunteers at eight sites in Thailand Rent faktisk: 51 vaccinated people had become infected within 3 years of receiving their last shot, as compared with 74 people in the placebo group. Immunity Oct 29;33(4): Induction of immunity to human immunodeficiency virus type-1 by vaccination. McElrath MJMcElrath MJ, Haynes BF.Haynes BF A recent vaccine regimen has shown modest efficacy against HIV-1 acquisition.

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