Presentation on theme: "About XP Xeroderma pigmentosum was first described in 1874 by Hebra and Kaposi. In 1882, Kaposi coined the term xeroderma pigmentosum for the condition,"— Presentation transcript:
About XP Xeroderma pigmentosum was first described in 1874 by Hebra and Kaposi. In 1882, Kaposi coined the term xeroderma pigmentosum for the condition, referring to its characteristic dry, pigmented skin.
Frequency The frequency in the United States is approximately 1 case per 250,000 population. The frequency in Europe is approximately 1 case per 250,000 population. In Japan 1 case per 40,000 population.
Race, Sex, and Age Cases of xeroderma pigmentosum are reported in persons of all races. An equal prevalence has been reported in males and females. The disease is usually detected at age 1-2 years.
More About XP Xeroderma pigmentosum is a rare disorder transmitted in an autosomal recessive manner. It is characterized by photosensitivity, pigmentary changes, premature skin aging, and malignant tumor development. These manifestations are due to a cellular hypersensitivity to ultraviolet (UV) radiation resulting from a defect in DNA repair.
Birth You can not detect it at or before the birth of the child, you don’t generally detect it until the child is 6 months when the first of three stages start.
Symptoms An unusually severe sunburn after a short sun exposure. The sunburn may last for several weeks. The sunburn usually occurs during a child’s first sun exposure. development of many freckles at an early age. Irregular dark spots. Thin skin. Excessive dryness. Rough-surfaced growths, and skin cancers. Eyes that are painfully sensitive to the sun and may easily become irritated, bloodshot, and clouded. Blistering or freckling on minimum sun exposure. Premature aging of skin, lips, eyes, mouth and tongue
Reproduction? Most people with xeroderma pigmentosum have normal sexual development and functioning, and they are able to have children. The probability of a person with xeroderma pigmentosum having a child with xeroderma pigmentosum is very small.